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Clinical and cardiac characteristics of primary bilateral macronodular adrenal hyperplasia.

Miao, S ; Lu, L ; et al.
In: Journal of medical biochemistry, Jg. 43 (2024-01-25), Heft 1, S. 19
Online academicJournal
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Background: Cardiovascular disease is the leading cause of death in Cushingžs syndrome (CS). Primary bilateral macro-nodular adrenal hyperplasia (PBMAH), is a rare cause of CS that is clinically distinct from the other common types of CS, but cardiac characteristics have been poorly studied.

Methods: The clinical data, steroid hormones and echocardiographic variables of 17 patients with PBMAH were collected. Twenty-one CS patients with cortisol-producing adenoma (CPA) were collected as controls. The similarities and differences of clinical and cardiac features between the two groups were compared.

Competing Interests: All the authors declare that they have no conflict of interest in this work.Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

(2024 Sisi Miao, Lin Lu, Shengyong Si, Dandan Peng, Ya Zhong, Zhijing Li, Zhenqiu Yu, published by CEON/CEES.)

Titel:
Clinical and cardiac characteristics of primary bilateral macronodular adrenal hyperplasia.
Autor/in / Beteiligte Person: Miao, S ; Lu, L ; Si, S ; Peng, D ; Zhong, Y ; Li, Z ; Yu, Z
Link:
Zeitschrift: Journal of medical biochemistry, Jg. 43 (2024-01-25), Heft 1, S. 19
Veröffentlichung: 2020- : Belgrade : Society of Medical Biochemists of Serbia ; <i>Original Publication</i>: Belgrade : Society of Medical Biochemists of Serbia, 2024
Medientyp: academicJournal
ISSN: 1452-8258 (print)
DOI: 10.5937/jomb0-43319
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article
  • Language: English
  • [J Med Biochem] 2024 Jan 25; Vol. 43 (1), pp. 19-35.
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  • Contributed Indexing: Keywords: PBMAH; cardiac; echocardiogram; primary bilateral macronodular adrenal hyperplasia; steroid hormone ; Local Abstract: [Publisher, Serbian] Kardiovaskularne bolesti su vodeći uzrok smrti kod Kušingovog sindroma (CS). Primarna bilateralna makro-nodularna hiperplazija nadbubrežne žlezde (PBMA ) je redak uzrok CS koji se klinički razlikuje od drugih uobičajenih tipova CS, ali kardijalne karakteristike su slabo proučavane. [Publisher, Serbian] Prikupljeni su klinički podaci, steroidni hormoni i ehokardiografske varijable 17 pacijenata sa PBMA. Dvadeset i jedan pacijent sa CS sa adenomom koji proizvodi kortizol (CPA) je sakupljen kao kontrola. Upoređene su sličnosti i razlike kliničkih i kardijalnih karakteristika između dve grupe. [Publisher, Serbian] U grupi PBMA udeo žena je bio manji (35,30 prema 100,00%), starosna dob je bila starija (55,76±2,42 godine prema 39,57±2,72 godine), a tok bolesti je bio duži 13,00 (5,00, 50) godine u odnosu na 1,58 (1,00, 5,00) godina. Procenat pacijenata sa PBMA sa hipertenzijom bio je veći nego kod pacijenata sa CPA (100,00% naspram 61,90%). Kortizol u plazmi i 24-časovni kortizol bez mokraće (24-časovni UFC) bili su niži kod pacijenata sa PBMA nego kod pacijenata sa CPA jutarnji kortizol 19,50 (15,35, 24,48) mg/dL naspram 28,30 (22,88, 29,89) mg/dL, 04h/dL, 04h/dL. 156,58) naspram 506,23 (292,53, 712,18) mg. Grupa PBMA imala je duži prečnik desne komore (24,06±1,23 mm naspram 20,48±0,83 mm), prečnik leve pretkomore (39,41±1,15 mm naspram 32,86±0,76 mm) i veću stopu dijastolne funkcije od 53% (s 76 ± 0,8%). CPA grupa. Univarijantna regresiona analiza je pokazala da kombinacija hipertenzije i trajanja hipertenzije ima značajne efekte na prečnik leve pretkomore (b=6,383, P=0,001; b = 0,276, P<0,001, respektivno) i E/A odnos (b=-0,496, P < 0,001, b=0,022, P<0,001, respektivno). Multivarijantna regresiona analiza je pokazala da nivo kortikosterona ima značajan uticaj na sistolni krvni pritisak (b=6,712, P=0,025). [Publisher, Serbian] U poređenju sa CPA, ventrikularna dijastolna disfunkcija je česta kod pacijenata sa PBMA pod relativno nižim nivoom kortizola. PBMA je imao visok nivo kortikosterona koji može igrati ulogu u razvoju hipertenzije i daljih srčanih promena.
  • Entry Date(s): Date Created: 20240318 Latest Revision: 20240319
  • Update Code: 20240319
  • PubMed Central ID: PMC10943461

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