Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice.
In: Journal of autoimmunity, Jg. 145 (2024-05-01), S. 103205
Online
academicJournal
Zugriff:
Peptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW maintains higher binding and inhibition efficiencies and achieves higher stability. Most importantly, D-ALW nanoparticles exhibit excellent kidney-targeting ability and prolong the half-life of the peptides in BALB/c mice. Additionally, compared to D-ALW, D-ALW nanoparticles significantly reduce the glomerular deposition of IgG and C3, improve renal histopathologies, such as glomerular proliferation and inflammatory cells infiltration, and markedly prolong lifespan in MRL/lpr lupus-prone mice. Overall, these results establish that the D-ALW nanoparticles offer synergistic benefits in both safety and efficacy, providing long-term renal preservation and treatment advantages in lupus nephritis.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice.
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Autor/in / Beteiligte Person: | Wang, Y ; Wang, S ; Liu, W ; Gu, H ; Luo, M ; Xiao, T ; Zhou, M ; Ran, Y ; Xiao, S ; Xia, Y ; Wang, H |
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Zeitschrift: | Journal of autoimmunity, Jg. 145 (2024-05-01), S. 103205 |
Veröffentlichung: | London : Academic Press ; <i>Original Publication</i>: London ; San Diego : Academic Press, c1988-, 2024 |
Medientyp: | academicJournal |
ISSN: | 1095-9157 (electronic) |
DOI: | 10.1016/j.jaut.2024.103205 |
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