The road to a polio-free Uganda; contribution of the Expanded Program on Immunization Laboratory (EPI-LAB) at Uganda Virus Research Institute.
In: African health sciences, Jg. 23 (2023-09-01), Heft 3, S. 186
Online
academicJournal
Zugriff:
Background: The control of poliomyelitis in Uganda dates back as far as 1950 and acute flaccid paralysis (AFP) surveillance has since been used as a criterion for identifying wild polioviruses. Poliovirus isolation was initially pursued through collaborative research however, in 1993, the Expanded Program on Immunization Laboratory (EPI-LAB) was established as a member of the Global Poliovirus Laboratory Network (GPLN) and spearheaded this activity at Uganda Virus Research Institute.
Objectives: The aim of this report is to document the progress and impact of the EPI-LAB on poliovirus eradication in Uganda.
Methods: Poliovirus detection and identification were achieved fundamentally through tissue culture and intra-typic differentiation of the poliovirus based on the real-time reverse transcriptase polymerase chain reaction (rRT PCR). The data obtained was entered into the national AFP database and analysed using EpiInfo TM statistical software.
Results: Quantitative and qualitative detection of wild and Sabin polioviruses corresponded with the polio campaigns. The WHO target indicators for AFP surveillance were achieved essentially throughout the study period.
Conclusion: Virological tracking coupled with attaining standard AFP surveillance indicators has been pivotal in achieving and maintaining the national wild polio-free status. Laboratory surveillance remains key in informing the certification process of polio eradication.
Competing Interests: “The authors declare no conflict of interest”.
(© 2023 Nanteza MB et al.)
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The road to a polio-free Uganda; contribution of the Expanded Program on Immunization Laboratory (EPI-LAB) at Uganda Virus Research Institute.
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Autor/in / Beteiligte Person: | Nanteza, MB ; Tushabe, P ; Bukenya, H ; Namuwulya, P ; Kabaliisa, T ; Birungi, M ; Tibanagwa, M ; Ampeire, I ; Kakooza, P ; Katushabe, E ; Bwogi, J ; Bakamutumaho, B ; Nanyunja, M ; Byabamazima, CR |
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Zeitschrift: | African health sciences, Jg. 23 (2023-09-01), Heft 3, S. 186 |
Veröffentlichung: | Kampala, Uganda : Faculty of Medicine, Makerere University, [2001-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1729-0503 (electronic) |
DOI: | 10.4314/ahs.v23i3.23 |
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