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Background: Craniosynostosis is a prevalent craniofacial malformation in Finland; however, comprehensive population-based epidemiological data are limited. This study aimed to estimate the total and birth prevalence of craniosynostosis in Finland from 1987 to 2010 and examine temporal trends.

Methods: We collected the data from nationwide registers maintained by the Finnish Institute for Health and Welfare and Statistics Finland, as well as treating hospitals, encompassing live births, stillbirths, terminations for fetal anomalies, and infant deaths with suspected or diagnosed craniosynostosis or skull deformation. A craniofacial surgeon and a clinical geneticist reviewed 1878 medical records for diagnostic confirmation.

Results: Out of 877 craniosynostosis cases, 83% were single-suture synostoses (all live births), 10% craniosynostosis syndromes, and 7% multisutural non-syndromic synostoses. Live birth prevalence from 1987 to 2010 was 6.0/10,000 live births, ranging from 5.0/10,000 in 1987 to 7.5/10,000 in 2010. Total prevalence, including live births, stillbirths, and terminations, varied from 5.0/10,000 in 1987 to 8.0/10,000 in 2010. Sagittal synostosis was the most common synostosis, with a prevalence of 3.9/10,000 live births, followed by metopic (0.6/10,000), unicoronal (0.4/10,000), and unilambdoid (0.1/10,000) synostoses.

Conclusions: The total combined prevalence of all craniosynostosis types significantly increased driven by a nonsignificant rise across all subgroups and a significant increase in the syndrome group. In live births increase was significant only within the syndrome subgroup, primarily due to an increase in Muenke syndrome patients. The rising prevalence of syndromes necessitates further investigation. Contrasting with trends in Europe, Australia, and the USA, Finland showed no significant increase in metopic craniosynostosis.

Titel:	Prevalence of craniosynostosis in Finland, 1987-2010: A population-based study.
Autor/in / Beteiligte Person:	Vuola, P ; Pakkasjärvi, N ; Ritvanen, A ; Heliövaara, A ; Tukiainen, E ; Gissler, M
Link:	Zum Volltext
Zeitschrift:	Birth defects research, Jg. 116 (2024-02-01), Heft 2, S. e2319
Veröffentlichung:	Hoboken, N.J. : John Wiley & Sons, Inc., 2024
Medientyp:	academicJournal
ISSN:	2472-1727 (electronic)
DOI:	10.1002/bdr2.2319
Schlagwort:	Pregnancy Female Humans Finland epidemiology Prevalence Europe Syndrome Stillbirth Craniosynostoses epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Birth Defects Res] 2024 Feb; Vol. 116 (2), pp. e2319. MeSH Terms: Stillbirth* ; Craniosynostoses* / epidemiology ; Pregnancy ; Female ; Humans ; Finland / epidemiology ; Prevalence ; Europe ; Syndrome References: Boulet, S. L., Rasmussen, S. A., & Honein, M. A. (2008). A population-based study of craniosynostosis in metropolitan Atlanta, 1989-2003. American Journal of Medical Genetics Part A, 146A(8), 984-991. https://doi.org/10.1002/ajmg.a.32208. ; Cohen, M. M., Jr., & Krelborg, S. (1992). Birth prevalence studies of the Crouzon syndrome: Comparison of direct and indirect methods. Clinical Genetics, 41(1), 12-15. https://doi.org/10.1111/j.1399-0004.1992.tb03620.x. ; Cohen, M. M., Kreiborg, S., Lammer, E. J., Cordero, J. F., Mastroiacovo, P., Erickson, J. D., Roeper, P., & Martínez-Frías, M. L. (1992). Birth prevalence study of the Apert syndrome. 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Prevalence of craniosynostosis in Finland, 1987-2010: A population-based study.