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During World War II, Charles H. Best utilized Charles R. Drew's plasma isolation and drying technique to lead Canada's initiative to provide dried serum as a means of primary resuscitation for British casualties on the frontlines. Serum was likely utilized over plasma for its volume expansion properties without the risk of clotting during prolonged storage. We reconstituted dried serum from 1943 and discovered intact albumin, as well as anti-thrombin, plasminogen, protein C and protein S activity. Proteomic analysis identified 71 proteins, most prominent being albumin, and positive for hepatitis B by serological testing. Transmission of blood-borne diseases ended the programme, until modern advances in testing and pathogen reduction revived this technology. We tested the latest iteration of Canadian freeze-dried plasma (FDP), which was stored for 4 years, and demonstrated that its clotting capacity remained equivalent to fresh frozen plasma. We recommend that FDP is a strong alternative to contemporary prehospital resuscitation fluids (e.g. normal saline/lactated Ringer's) in managing prehospital haemorrhage where whole blood is unavailable.

Titel:	Past meets present: Reviving 80-year-old Canadian dried serum from World War II and its significance in advancing modern freeze-dried plasma for prehospital management of haemorrhage.
Autor/in / Beteiligte Person:	Singh, K ; Peng, HT ; Moes, K ; Kretz, CA ; Beckett, A
Link:	Zum Volltext
Zeitschrift:	British journal of haematology, Jg. 204 (2024-04-01), Heft 4, S. 1515-1522
Veröffentlichung:	Oxford : Wiley-Blackwell ; <i>Original Publication</i>: Oxford : Blackwell Scientific Publications, 2024
Medientyp:	academicJournal
ISSN:	1365-2141 (electronic)
DOI:	10.1111/bjh.19298
Schlagwort:	Humans Aged, 80 and over Proteomics Canada Hemorrhage Plasma Albumins World War II Emergency Medical Services methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Br J Haematol] 2024 Apr; Vol. 204 (4), pp. 1515-1522. <i>Date of Electronic Publication: </i>2024 Jan 25. MeSH Terms: World War II* ; Emergency Medical Services* / methods ; Humans ; Aged, 80 and over ; Proteomics ; Canada ; Hemorrhage ; Plasma ; Albumins References: Landsteiner K. Ueber Agglutinationser‐scheinungen normalen menschlichen Blutes. Wien Clin Wschr. 1901;14:1132–1134. ; Pinkerton P. Pioneers & pathfinders: Canadian surgeons and the introduction of blood transfusion in war surgery. Transfus Med Rev. 2008;22:77–86. https://doi.org/10.1016/j.tmrv.2023.03.002. ; Franco A, Cortes J, Alvarez J, Diz JC. The development of blood transfusion: the contributions of Norman Bethune in the Spanish Civil War (1936–1939). Can J Anaesth. 1996;43(10):1076–1078. https://doi.org/10.1007/BF03011914. ; Tan S, Merritt C. Charles Richard Drew (1904–1950): father of blood banking. 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Anesthesiology. 2022;136(2):327–335. https://doi.org/10.1097/ALN.0000000000004089. ; Peng HT, Rhind SG, Devine D, Jenkins C, Beckett A. Ex vivo hemostatic and immuno‐inflammatory profiles of freeze‐dried plasma. Transfusion. 2021;61(Suppl 1):S130. https://doi.org/10.1111/trf.16502. Grant Information: CF Surgeon General's Health Research Program; Canadian Forces Health Services; Defence Research and Development Canada; Canadian Blood Services Postdoctoral Fellowship Program Contributed Indexing: Keywords: blood products; blood transfusion; freeze‐dried plasma; haemorrhage; hepatitis; prehospital care Substance Nomenclature: 0 (Albumins) Entry Date(s): Date Created: 20240125 Date Completed: 20240411 Latest Revision: 20240411 Update Code: 20240411

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Past meets present: Reviving 80-year-old Canadian dried serum from World War II and its significance in advancing modern freeze-dried plasma for prehospital management of haemorrhage.