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Background: Plantar warts are common infectious cutaneous growths causing severe physiological and psychological discomforts in patients and heaving global financial burdens. However, paucity of clear-cut guidelines for plantar warts, selecting appropriate treatments for plantar warts remains challenging. The objective of the study is to evaluate the efficacy and safety of common treatments for plantar warts.

Methods: PubMed, EMbase, and The Cochrane Library were searched from inception to March 1, 2023 for randomized controlled trials (RCTs) of plantar warts. The primary outcome (complete response) and secondary outcome (recurrence and pain) were extracted and combined using Bayesian network meta-analysis (NMA) with random-effect and fixed-effect models.

Results: Totally, 33 RCTs were included in the systematic review and quantitative NMA. In NMA of complete response, topical application of 1% cantharidin, 20% podophylotoxin, 30% salicylic acid (CPS), microneedles plus bleomycin (MNB), and intralesional bleomycin injection (INB) were the only three treatments significantly superior to no treatment (NT) and CPS was of the highest possibility to be the top-ranked treatment (SUCRA = 0.9363). However, traditional warts treatments, salicylic acid (SA) and cryotherapy were not superior to NT.

Conclusions: The NMA has produced evidence for using CPS, MNB, and INB, which are all topical antimitotic treatments, to improve the management of plantar warts. The classic treatment modalities for plantar warts, including SA and cryotherapy, may play a less important role in the clinical practice of plantar warts.

Titel:	Topical antimitotic treatments for plantar warts are more beneficial: A Bayesian network meta-analysis of randomized controlled trials.
Autor/in / Beteiligte Person:	Xu, Y ; Wang, Y ; Huang, K ; Huang, W ; Zhao, S ; Jiang, Z
Link:	Zum Volltext
Zeitschrift:	Journal of evidence-based medicine, Jg. 17 (2024-03-01), Heft 1, S. 37-53
Veröffentlichung:	Oxford : Wiley-Blackwell, 2024
Medientyp:	academicJournal
ISSN:	1756-5391 (electronic)
DOI:	10.1111/jebm.12586
Schlagwort:	Humans Network Meta-Analysis Randomized Controlled Trials as Topic Salicylic Acid Bleomycin therapeutic use Treatment Outcome Antimitotic Agents therapeutic use Warts drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Meta-Analysis; Journal Article Language: English [J Evid Based Med] 2024 Mar; Vol. 17 (1), pp. 37-53. <i>Date of Electronic Publication: </i>2024 Jan 19. MeSH Terms: Antimitotic Agents* / therapeutic use ; Warts* / drug therapy ; Humans ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Salicylic Acid ; Bleomycin / therapeutic use ; Treatment Outcome References: Witchey DJ, Witchey NB, Roth‐Kauffman MM, Kauffman MK. Plantar warts: epidemiology, pathophysiology, and clinical management. J Am Osteopath Assoc. 2018;118(2):92‐105. ; Oreja SG, Alvaro‐Afonso FJ, Sevillano‐Fernandez D, Tardaguila‐Garcia A, Lopez‐Moral M, JL Lazaro‐Martinez. A noninvasive method for diagnosing plantar warts caused by human papillomavirus (HPV). J Med Virol. 2022;94(6):2897‐2901. ; Mohta A, Jain S, Kushwaha R, Singh A, Gautam U, Nyati A. 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J Clin Virol. 2013;57(3):227‐232. Grant Information: CMCMII-202200349 Mobile Healthcare: Ministry of Education, China Mobile Joint Laboratory Contributed Indexing: Keywords: CPS; HPV; antimitotic treatment; bleomycin; combined therapy; microneedles; network meta‐analysis; plantar warts Substance Nomenclature: 0 (Antimitotic Agents) ; O414PZ4LPZ (Salicylic Acid) ; 11056-06-7 (Bleomycin) Entry Date(s): Date Created: 20240120 Date Completed: 20240401 Latest Revision: 20240401 Update Code: 20240401

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Topical antimitotic treatments for plantar warts are more beneficial: A Bayesian network meta-analysis of randomized controlled trials.