Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat.
In: Archives of Razi Institute, Jg. 78 (2023-08-31), Heft 4, S. 1359
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Zugriff:
Ginseng is known as the king of all herbs in terms of antioxidant and anti-inflammatory activities and recently has become more involved in the treatment of neurological diseases. In this regard, this study aimed to determine the effects of Ginsenosides on pentylenetetrazol-induced epilepsy during the estrus cycle. For this purpose, 30 rats were randomly divided into five groups, namely control (saline), valproic acid (VPA, 75 mg/kg), Ginsenosides (50 mg/kg), Ginsenosides (100 mg/kg), and Ginsenosides (150 mg/kg) with four subgroups (proestrus, estrus, metestrus, and diestrus). Subsequently, the initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS), and seizure duration (SD) were determined. According to the results, ITMS and ITTS significantly increased in the VPA-treated group ( P <0.05). Ginsenosides (100 and 150 mg/kg) administration significantly increased ITMS and ITTS ( P <0.05). Moreover, the ITMS and ITTS in Ginsenosides -treated rats were significantly higher in luteal phases, compared to the follicular phase ( P <0.05). In addition, pretreatment with VPA significantly decreased SD, compared to the control group ( P <0.05). A significant decrease in SD was observed in the rats pretreated with ginsenosides (100 and 150 mg/kg) ( P <0.05). Seizure duration significantly decreased in animals that received Ginsenosides in luteal phases, compared to the follicular phase ( P <0.05). These results suggested that Ginsenosides have anticonvulsant effects that are more prominent during the luteal phase than the follicular phase.
Competing Interests: The authors declare that they have no conflict of interest.
Titel: |
Effects of Ginsenosides on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat.
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Autor/in / Beteiligte Person: | Elahinia, A ; Hassanpour, S ; Ghotbitabar, Z |
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Zeitschrift: | Archives of Razi Institute, Jg. 78 (2023-08-31), Heft 4, S. 1359 |
Veröffentlichung: | 2006- : Karaj, Iran : Razi Vaccine and Serum Research Institute ; <i>Original Publication</i>: 1999-2005 : Tehran, Iran : Razi Vaccine and Serum Research Institute, 2023 |
Medientyp: | academicJournal |
ISSN: | 2008-9872 (electronic) |
DOI: | 10.32592/ARI.2023.78.4.1359 |
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