Einzeltreffer — DigiBib

Aims: The influence of social determinants of health (SDOH) on the prognosis of Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim to evaluate the contribution of educational status on outcomes in patients with HFrEF.

Methods: We used data from the WARCEF trial, which randomized HFrEF patients with sinus rhythm to receive Warfarin or Aspirin; educational status of patients enrolled was collected at baseline. We defined three levels of education: low, medium and high level, according to the highest qualification achieved or highest school grade attended. We analysed the impact of the educational status on the risk of the primary composite outcome of all-cause death, ischemic stroke (IS) and intracerebral haemorrhage (ICH); components of the primary outcome were also analysed as secondary outcomes.

Results: 2295 patients were included in this analysis; of these, 992 (43.2%) had a low educational level, 947 (41.3%) had a medium education level and the remaining 356 (15.5%) showed a high educational level. Compared to patients with high educational level, those with low educational status showed a high risk of the primary composite outcome (adjusted hazard ratio [aHR]: 1.31, 95% confidence intervals [CI] 1.02-1.69); a non-statistically significant association was observed in those with medium educational level (aHR: 1.20, 95%CI: .93-1.55). Similar results were observed for all-cause death, while no statistically significant differences were observed for IS or ICH.

Conclusion: Compared to patients with high educational levels, those with low educational status had worse prognosis. SDOH should be considered in patients with HFrEF.

Clinical Trial Registration: NCT00041938.

Titel:	Educational status affects prognosis of patients with heart failure with reduced ejection fraction: A post-hoc analysis from the WARCEF trial.
Autor/in / Beteiligte Person:	Corica, B ; Romiti, GF ; Simoni, AH ; Mei, DA ; Bucci, T ; Thompson, JLP ; Qian, M ; Homma, S ; Proietti, M ; Lip, GYH
Link:	Zum Volltext
Zeitschrift:	European journal of clinical investigation, Jg. 54 (2024-05-01), Heft 5, S. e14152
Veröffentlichung:	Oxford : Wiley ; <i>Original Publication</i>: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation., 2024
Medientyp:	academicJournal
ISSN:	1365-2362 (electronic)
DOI:	10.1111/eci.14152
Schlagwort:	Humans Cerebral Hemorrhage Educational Status Prognosis Stroke Volume Warfarin Heart Failure drug therapy Heart Failure complications Ischemic Stroke
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: WARCEF Investigators Publication Type: Journal Article; Randomized Controlled Trial Language: English [Eur J Clin Invest] 2024 May; Vol. 54 (5), pp. e14152. <i>Date of Electronic Publication: </i>2024 Jan 11. MeSH Terms: Heart Failure* / drug therapy ; Heart Failure* / complications ; Ischemic Stroke* ; Humans ; Cerebral Hemorrhage ; Educational Status ; Prognosis ; Stroke Volume ; Warfarin References: Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13:368‐378. ; Lawson CA, Zaccardi F, Squire I, et al. 20‐year trends in cause‐specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population‐based study. Lancet Public Health. 2019;4:e406‐e420. ; Witte KK, Patel PA, Walker AMN, et al. Socioeconomic deprivation and mode‐specific outcomes in patients with chronic heart failure. 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Grant Information: U01-NS-039143 to Dr. Thompson United States NS NINDS NIH HHS; U01-NS-043975 to Dr. Homma United States NS NINDS NIH HHS; U01-NS-039143 to Dr. Thompson United States NS NINDS NIH HHS; U01-NS-043975 to Dr. Homma United States NS NINDS NIH HHS Contributed Indexing: Keywords: HFrEF; educational level; heart failure; social determinants of health Molecular Sequence: ClinicalTrials.gov NCT00041938 Substance Nomenclature: 5Q7ZVV76EI (Warfarin) Entry Date(s): Date Created: 20240111 Date Completed: 20240417 Latest Revision: 20240429 Update Code: 20240430

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Educational status affects prognosis of patients with heart failure with reduced ejection fraction: A post-hoc analysis from the WARCEF trial.