Comparative Treatment of Mucocutaneous Lesions in Hereditary Haemorrhagic Telangiectasia Patients With Dual Sequential Pulsed Dye Laser and Neodymium: Yttrium-Aluminium-Garnet Versus Neodymium: Yttrium-Aluminium-Garnet Laser Alone: A Double-Blind Randomized Controlled Study With Quality-of-Life Evaluation.

Cubiró, X ; Garcia-Melendo, C ; et al.

In: Actas dermo-sifiliograficas, Jg. 115 (2024-03-01), Heft 3, S. T246

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Background: Hereditary haemorrhagic telangiectasia (HHT) is characterized by the presence of telangiectases and larger arteriovenous malformations in different organs. Mucocutaneous telangiectases can bleed and become an aesthetic concern, impairing quality of life (QoL). However, the best treatment approach has not been defined yet.

Objective: To evaluate the efficacy and safety of dual wavelength sequential 595/1064nm laser (DWSL) compared to 1064nm laser (Nd:YAG) alone. Secondarily, to evaluate QoL impairment in HHT patients, and its improvement with laser therapy.

Methods: A comparative randomized split-body double-blinded prospective study (DWSL vs Nd:YAG). Demographic, clinical and treatment characteristics were recorded. The severity and degree of improvement were evaluated by three blinded examiners who scored pre-treatment and post-treatment pictures on a 5-point scale. Patients fulfilled Skindex-29 and FACE-Q® tests and assessed procedure-associated pain and patient satisfaction.

Results: 111 treatment areas (55 treated with DWSL and 56 with Nd:YAG) from 26 patients were analyzed. The median number of laser sessions was 2 (interquartile range [IQR] 2-4; mean 2.90 vs 2.88, respectively). The median improvement score, irrespective of location, was significantly higher for Nd:YAG compared to DWSL: 3 (IQR 2-3; mean 2.61) vs 2 (IQR 2-3; mean 2.32), p=0.031. Both FACE-Q index and Skindex-29 test results improved significantly (p<0.001), and 92.4% patients reported a high degree of satisfaction (≥8). No severe adverse events were reported.

Conclusions: DWSL and Nd:YAG laser are convenient, safe and effective treatment options for mucocutaneous telangiectases in HHT patients. However, Nd:YAG delivered better results with better tolerability. QoL was significantly improved by both treatments.

Titel:	Comparative Treatment of Mucocutaneous Lesions in Hereditary Haemorrhagic Telangiectasia Patients With Dual Sequential Pulsed Dye Laser and Neodymium: Yttrium-Aluminium-Garnet Versus Neodymium: Yttrium-Aluminium-Garnet Laser Alone: A Double-Blind Randomized Controlled Study With Quality-of-Life Evaluation.
Autor/in / Beteiligte Person:	Cubiró, X ; Garcia-Melendo, C ; Morales-Munera, CE ; Riera-Mestre, A ; Torres-Iglesias, R ; Villanueva, B ; Puig, L ; Baselga, E
Link:	Zum Volltext
Zeitschrift:	Actas dermo-sifiliograficas, Jg. 115 (2024-03-01), Heft 3, S. T246
Veröffentlichung:	<2009- > : Madrid : Elsevier España ; <i>Original Publication</i>: Madrid, Academia Española de Dermatología y Sifilografía., 2024
Medientyp:	academicJournal
ISSN:	1578-2190 (electronic)
DOI:	10.1016/j.ad.2024.01.003
Schlagwort:	Humans Neodymium Prospective Studies Quality of Life Treatment Outcome Aluminum Lasers, Dye adverse effects Lasers, Solid-State adverse effects Telangiectasia, Hereditary Hemorrhagic complications Telangiectasis etiology Telangiectasis radiotherapy Yttrium
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Transliterated Title: [Artículo traducido] Tratamiento comparativo de lesiones mucocutáneas en pacientes con telangiectasia hemorrágica hereditaria con láser dual secuencial de colorante pulsado y neodimio: itrio-aluminio-granate versus neodimio: itrio-aluminio-granate solo: un estudio controlado aleatorizado doble ciego con evaluación de la calidad de vida. Publication Type: Randomized Controlled Trial; Journal Article Language: English; Spanish; Castilian [Actas Dermosifiliogr] 2024 Mar; Vol. 115 (3), pp. T246-T257. <i>Date of Electronic Publication: </i>2024 Jan 05. MeSH Terms: Aluminum* ; Lasers, Dye* / adverse effects ; Lasers, Solid-State* / adverse effects ; Telangiectasia, Hereditary Hemorrhagic* / complications ; Telangiectasis* / etiology ; Telangiectasis* / radiotherapy ; Yttrium* ; Humans ; Neodymium ; Prospective Studies ; Quality of Life ; Treatment Outcome Contributed Indexing: Keywords: Calidad de vida; Dual 595/1064-nm wavelength laser; Dual sequential PDL-Nd:YAG laser; Hereditary haemorrhagic telangiectasia; Láser Nd:YAG; Láser de estado sólido; Láser dual de longitud de onda de 595/1064nm; Láser dual secuencial PDL-Nd:YAG; Nd:YAG laser; Quality of life; Solid-state laser; Telangiectasia hemorrágica hereditaria Substance Nomenclature: CPD4NFA903 (Aluminum) ; 2I87U3734A (Neodymium) ; 58784XQC3Y (Yttrium) ; 0 (yttrium-aluminum-garnet) Entry Date(s): Date Created: 20240107 Date Completed: 20240312 Latest Revision: 20240320 Update Code: 20240320

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