Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article
- Language: English
- [Arch Toxicol] 2024 Mar; Vol. 98 (3), pp. 911-928. <i>Date of Electronic Publication: </i>2024 Jan 05.
- MeSH Terms: Endocrine Disruptors* ; Mice ; Animals ; Male ; Female ; Mice, Inbred C57BL ; Receptors, Cytoplasmic and Nuclear / metabolism ; Liver ; Glucose / metabolism ; Lipids ; Benzhydryl Compounds
- References: Alonso-Magdalena P, Morimoto S, Ripoll C et al (2006) The estrogenic effect of bisphenol A disrupts pancreatic β-cell function in vivo and induces insulin resistance. Environ Health Perspect 114:106–112. (PMID: 16393666) ; Angle BM, Do RP, Ponzi D et al (2013) Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation. Reprod Toxicol 42:256–268. https://doi.org/10.1016/J.REPROTOX.2013.07.017. (PMID: 10.1016/J.REPROTOX.2013.07.01723892310) ; Ariemma F, D’Esposito V, Liguoro D et al (2016) Low-dose bisphenol-A impairs adipogenesis and generates dysfunctional 3T3-L1 adipocytes. PLoS ONE 11:e0150762. (PMID: 269425974778877) ; Attema B, Janssen AWF, Rijkers D et al (2022) Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice. Mol Metab 2022:11602. ; Behr A-C, Kwiatkowski A, Ståhlman M et al (2020a) Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells. Arch Toxicol 94:1673–1686. (PMID: 322534668241792) ; Behr A-C, Plinsch C, Braeuning A, Buhrke T (2020b) Activation of human nuclear receptors by perfluoroalkylated substances (PFAS). Toxicol in Vitro 62:104700. (PMID: 31676336) ; Bjork JA, Butenhoff JL, Wallace KB (2011) Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology 288:8–17. https://doi.org/10.1016/j.tox.2011.06.012. (PMID: 10.1016/j.tox.2011.06.01221723365) ; Brulport A, Vaiman D, Bou-Maroun E et al (2020) Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice. BMC Genomics 21:1–16. https://doi.org/10.1186/S12864-020-07294-3/TABLES/1. (PMID: 10.1186/S12864-020-07294-3/TABLES/1) ; Cai D, Yuan M, Frantz DF et al (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat Med 11:183–190. (PMID: 156851731440292) ; Cox HM, Tough IR, Woolston A-M et al (2010) Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. Cell Metab 11:532–542. https://doi.org/10.1016/j.cmet.2010.04.014. (PMID: 10.1016/j.cmet.2010.04.014205191242890049) ; Darbre PD (2017) Endocrine disruptors and obesity. Curr Obes Rep 6:18–27. (PMID: 282051555359373) ; DeWitt JC, Copeland CB, Strynar MJ, Luebke RW (2008) Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environ Health Perspect 116:644–650. (PMID: 184703132367677) ; Dhawan SS, Xia S, Tait DS et al (2018) Oral dosing of rodents using a palatable tablet. Psychopharmacology 235:1527–1532. https://doi.org/10.1007/s00213-018-4863-2. (PMID: 10.1007/s00213-018-4863-2295118085919998) ; Fragki S, Dirven H, Fletcher T et al (2021) Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not? Crit Rev Toxicol 51:141–164. (PMID: 33853480) ; Gore AC, Chappell VA, Fenton SE et al (2015) EDC-2: the Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 36:E1–E150. (PMID: 265445314702494) ; Gwag T, Meng Z, Sui Y et al (2019) Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol 70:930–940. https://doi.org/10.1016/j.jhep.2018.12.038. (PMID: 10.1016/j.jhep.2018.12.038306774596462244) ; Hakkola J, Rysä J, Hukkanen J (2016) Regulation of hepatic energy metabolism by the nuclear receptor PXR. Biochim Biophys Acta (BBA) Gene Regul Mech 1859:1072–1082. https://doi.org/10.1016/j.bbagrm.2016.03.012. (PMID: 10.1016/j.bbagrm.2016.03.012) ; Hassani-Nezhad-Gashti F, Rysä J, Kummu O et al (2018) Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. Biochem Pharmacol 148:253–264. https://doi.org/10.1016/j.bcp.2018.01.001. (PMID: 10.1016/j.bcp.2018.01.00129309761) ; Haverinen E, Fernandez MF, Mustieles V, Tolonen H (2021) Metabolic syndrome and endocrine disrupting chemicals: an overview of exposure and health effects. Int J Environ Res Public Health 18:13047. (PMID: 349486528701112) ; Heindel JJ, Vom Saal FS, Blumberg B et al (2015) Parma consensus statement on metabolic disruptors. Environ Health 14:54. https://doi.org/10.1186/s12940-015-0042-7. (PMID: 10.1186/s12940-015-0042-7260920374473834) ; Heindel JJ, Blumberg B, Cave M et al (2017) Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol 68:3–33. (PMID: 27760374) ; Hukkanen J, Hakkola J (2020) PXR and 4β-hydroxycholesterol axis and the components of metabolic syndrome. Cells 9:2445. https://doi.org/10.3390/cells9112445. (PMID: 10.3390/cells9112445331824777696146) ; Intrasuksri U, Rangwala SM, Noonan DJ, Feller DR (1998) Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids. General Pharmacol Vasc Syst 31:187–197. ; Jenkins S, Wang J, Eltoum I et al (2011) Chronic oral exposure to bisphenol A results in a nonmonotonic dose response in mammary carcinogenesis and metastasis in MMTV-erbB2 mice. Environ Health Perspect 119:1604–1609. (PMID: 219887663226508) ; Ji H, Song N, Ren J et al (2020) Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice. Sci Total Environ 703:134681. (PMID: 31715463) ; Jiang Y, Feng D, Ma X et al (2019) Pregnane X receptor regulates liver size and liver cell fate by yes-associated protein activation in mice. Hepatology 69:343–358. https://doi.org/10.1002/hep.30131. (PMID: 10.1002/hep.3013130048004) ; Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473–481. (PMID: 10953022380258) ; Karpale M, Käräjämäki AJ, Kummu O et al (2021) Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism. Br J Pharmacol 178:2461–2481. https://doi.org/10.1111/bph.15433. (PMID: 10.1111/bph.1543333687065) ; Ke ZH, Pan JX, Jin LY et al (2016) Bisphenol a exposure may induce hepatic lipid accumulation via reprogramming the DNA methylation patterns of genes involved in lipid metabolism. Sci Rep. https://doi.org/10.1038/SREP31331. (PMID: 10.1038/SREP31331279767045157041) ; Kersten S (2014) Integrated physiology and systems biology of PPARα. Mol Metab 3:354–371. https://doi.org/10.1016/j.molmet.2014.02.002. (PMID: 10.1016/j.molmet.2014.02.002249448964060217) ; Krey G, Braissant O, L’Horset F et al (1997) Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 11:779–791. https://doi.org/10.1210/mend.11.6.0007. (PMID: 10.1210/mend.11.6.00079171241) ; Le Corre L, Besnard P, Chagnon M-C (2015) BPA, an energy balance disruptor. Crit Rev Food Sci Nutr 55:769–777. (PMID: 24915348) ; Legeay S, Faure S (2017) Is bisphenol A an environmental obesogen? Fundam Clin Pharmacol 31:594–609. (PMID: 28622415) ; Ling Z, Shu N, Xu P et al (2016) Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes. Biochem Pharmacol 100:98–111. https://doi.org/10.1016/j.bcp.2015.11.023. (PMID: 10.1016/j.bcp.2015.11.02326616219) ; Liu J, Yu P, Qian W et al (2013) Perinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposure. PLoS ONE 8:e64143. (PMID: 236755233651242) ; Liu X, Sakai H, Nishigori M et al (2019) Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors. Toxicol Appl Pharmacol 377:114610. (PMID: 31195007) ; Liu B, Zhu L, Wang M, Sun Q (2023) Associations between per-and polyfluoroalkyl substances exposures and blood lipid levels among adults—a meta-analysis. Environ Health Perspect 131:056001. (PMID: 3714124410159273) ; Louisse J, Rijkers D, Stoopen G et al (2020) Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells. Arch Toxicol 94:3137–3155. https://doi.org/10.1007/s00204-020-02808-0. (PMID: 10.1007/s00204-020-02808-0325880877415755) ; Marmugi A, Ducheix S, Lasserre F et al (2012) Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology 55:395–407. (PMID: 21932408) ; Martins T, Matos AF, Soares J et al (2022) Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice. J Am Assoc Lab Anim Sci 61:89–95. (PMID: 348479848786383) ; McCabe C, Anderson OS, Montrose L et al (2017) Sexually dimorphic effects of early-life exposures to endocrine disruptors: sex-specific epigenetic reprogramming as a potential mechanism. Curr Environ Health Rep 4:426–438. (PMID: 289801595784425) ; Moon MK, Jeong I-K, Oh TJ et al (2015) Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance. J Endocrinol 226:35–42. (PMID: 25972359) ; Moriyama K, Tagami T, Akamizu T et al (2002) Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab 87:5185–5190. (PMID: 12414890) ; Murakami K, Ide T, Suzuki M et al (1999) Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor α. Biochem Biophys Res Commun 260:609–613. (PMID: 10403814) ; Nakamura K, Moore R, Negishi M, Sueyoshi T (2007) Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J Biol Chem 282:9768–9776. https://doi.org/10.1074/jbc.M610072200. (PMID: 10.1074/jbc.M61007220017267396) ; OECD (2008) OECD guidelines for the testing of chemicals: repeated dose 28-day oral toxicity study in rodents. Drug Chem Toxicol 34:13. ; Patsouris D, Reddy JK, Müller M, Kersten S (2006) Peroxisome proliferator-activated receptor α mediates the effects of high-fat diet on hepatic gene expression. Endocrinology 147:1508–1516. (PMID: 16357043) ; Rakhshandehroo M, Sanderson LM, Matilainen M et al (2007) Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res 2007:1. ; Rando G, Wahli W (2011) Sex differences in nuclear receptor-regulated liver metabolic pathways. Biochim Biophys Acta (BBA) Mol Basis Dis 1812:964–973. ; Rebholz SL, Jones T, Herrick RL et al (2016) Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice. Toxicol Rep 3:46–54. https://doi.org/10.1016/j.toxrep.2015.11.004. (PMID: 10.1016/j.toxrep.2015.11.00426942110) ; Rosen MB, Das KP, Rooney J et al (2017) PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology 387:95–107. (PMID: 28558994) ; Rysä J, Buler M, Savolainen MJ et al (2013) Pregnane X receptor agonists impair postprandial glucose tolerance. Clin Pharmacol Ther 93:556–563. https://doi.org/10.1038/clpt.2013.48. (PMID: 10.1038/clpt.2013.4823588309) ; Schlezinger JJ, Puckett H, Oliver J et al (2020) Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet. Toxicol Appl Pharmacol 405:115204. (PMID: 328227377503133) ; Schlezinger JJ, Hyötyläinen T, Sinioja T et al (2021) Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized pparα mice fed an american diet. Toxicol Appl Pharmacol 426:115644. (PMID: 342524128338894) ; Small L, Ehrlich A, Iversen J et al (2022) Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice. Mol Metab 57:101440. https://doi.org/10.1016/j.molmet.2022.101440. (PMID: 10.1016/j.molmet.2022.101440350264358810558) ; Spruiell K, Richardson RM, Cullen JM et al (2014) Role of Pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem 289:3244–3261. https://doi.org/10.1074/jbc.M113.494575. (PMID: 10.1074/jbc.M113.49457524362030) ; Staels B, Dallongeville J, Auwerx J et al (1998) Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98:2088–2093. (PMID: 9808609) ; Takacs ML, Abbott BD (2007) Activation of mouse and human peroxisome proliferator–activated receptors (α, β/δ, γ) by perfluorooctanoic acid and perfluorooctane sulfonate. Toxicol Sci 95:108–117. (PMID: 17047030) ; Tohmé M, Prud’homme SM, Boulahtouf A et al (2014) Estrogen-related receptor γ is an in vivo receptor of bisphenol A. FASEB J 28:3124–3133. (PMID: 24744145) ; Toye AA, Lippiat JD, Proks P et al (2005) A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48:675–686. https://doi.org/10.1007/s00125-005-1680-z. (PMID: 10.1007/s00125-005-1680-z15729571) ; Vandenberg LN, Chahoud I, Heindel JJ et al (2010) Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ Health Perspect 118:1055–1070. (PMID: 203388582920080) ; Vandenberg LN, Welshons WV, vom Saal FS et al (2014) Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environ Health 13:46. https://doi.org/10.1186/1476-069X-13-46. (PMID: 10.1186/1476-069X-13-46249614404069342) ; Villar-Pazos S, Martinez-Pinna J, Castellano-Muñoz M et al (2017) Molecular mechanisms involved in the non-monotonic effect of bisphenol—a on Ca 2+ entry in mouse pancreatic β-cells. Sci Rep 7:11770. (PMID: 289241615603522) ; Wang L, Wang Y, Liang Y et al (2013) Specific accumulation of lipid droplets in hepatocyte nuclei of PFOA-exposed BALB/c mice. Sci Rep 3:1–5. ; Wolf DC, Moore T, Abbott BD et al (2008) Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-α knockout and wild-type mice. Toxicol Pathol 36:632–639. (PMID: 18467680) ; Yan S, Zhang H, Zheng F et al (2015) Perfluorooctanoic acid exposure for 28 days affects glucose homeostasis and induces insulin hypersensitivity in mice. Sci Rep 5:11029. (PMID: 260663764464286) ; Zhang L (2021) Method for voluntary oral administration of drugs in mice. STAR Protoc 2:100330. https://doi.org/10.1016/j.xpro.2021.100330. (PMID: 10.1016/j.xpro.2021.100330336447707887435) ; Zhou C (2016) Novel functions of PXR in cardiometabolic disease. Biochim Biophys Acta (BBA) Gene Regul Mech 1859:1112–1120. https://doi.org/10.1016/j.bbagrm.2016.02.015. (PMID: 10.1016/j.bbagrm.2016.02.015) ; Zhou J, Zhai Y, Mu Y et al (2006) A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281:15013–15020. https://doi.org/10.1074/jbc.M511116200. (PMID: 10.1074/jbc.M51111620016556603) ; Zhou J, Febbraio M, Wada T et al (2008) Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARγ in promoting steatosis. Gastroenterology 134:556-567.e1. https://doi.org/10.1053/j.gastro.2007.11.037. (PMID: 10.1053/j.gastro.2007.11.03718242221) ; Zoeller RT, Brown TR, Doan LL et al (2012) Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology 153:4097–4110. (PMID: 227339743423612)
- Grant Information: 825762 H2020 Health; 323706 Academy of Finland; 336449 Academy of Finland
- Contributed Indexing: Keywords: Endocrine-disrupting chemicals (EDCs); Glucose metabolism; Hepatic steatosis; Lipid metabolism; Metabolic disruption; Metabolism-disrupting chemicals; Nuclear receptors
- Substance Nomenclature: 0 (Endocrine Disruptors) ; 0 (Receptors, Cytoplasmic and Nuclear) ; IY9XDZ35W2 (Glucose) ; 0 (Lipids) ; 0 (Benzhydryl Compounds)
- Entry Date(s): Date Created: 20240105 Date Completed: 20240214 Latest Revision: 20240409
- Update Code: 20240409
- PubMed Central ID: PMC10861694
|