Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.

Sun, X ; Pan, Y ; et al.

In: Journal of ethnopharmacology, Jg. 322 (2024-03-25), S. 117672

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Aim of the Study: Naoxinqing (NXQ) tablets are derived from persimmon leaves and are widely used in China for promoting blood circulation and removing blood stasis in China. We aimed to explore whether NXQ has the therapeutic effect on ischemic stroke and explored its possible mechanism.

Materials and Methods: The cerebral artery occlusion/reperfusion (MCAO/R) surgery was used to establish the cerebral ischemic/reperfusion rat model. NXQ (60 mg/kg and 120 mg/kg) were administered orally. The TTC staining, whole brain water content, histopathology staining, immunofluorescent staining, enzyme-linked immunosorbent assay (ELISA) and Western blot analyses were performed to determine the therapeutical effect of NXQ on MCAO/R rats.

Results: The study demonstrated that NXQ reduced the cerebral infarction volumes and neurologic deficits in MCAO/R rats. The neuroprotective effects of NXQ were accompanied by inhibited oxidative stress and inflammation. The nerve regeneration effects of NXQ were related to regulating the AMPKα/NAMPT/SIRT1/PGC-1α pathway.

Conclusion: In summary, our results revealed that NXQ had a significant protective effect on cerebral ischemia-reperfusion injury in rats. This study broadens the therapeutic scope of NXQ tablets and provides new neuroprotective mechanisms of NXQ as an anti-stroke therapeutic agent.

Competing Interests: Declaration of competing interest All authors disclosed no relevant relationships.

Titel:	Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
Autor/in / Beteiligte Person:	Sun, X ; Pan, Y ; Luo, Y ; Guo, H ; Zhang, Z ; Wang, D ; Li, C
Link:	Zum Volltext
Zeitschrift:	Journal of ethnopharmacology, Jg. 322 (2024-03-25), S. 117672
Veröffentlichung:	Limerick : Elsevier Sequoia ; <i>Original Publication</i>: Lausanne, Elsevier Sequoia., 2024
Medientyp:	academicJournal
ISSN:	1872-7573 (electronic)
DOI:	10.1016/j.jep.2023.117672
Schlagwort:	Rats Animals Sirtuin 1 metabolism Brain Infarction, Middle Cerebral Artery pathology Stroke drug therapy Brain Ischemia metabolism Metabolic Diseases drug therapy Reperfusion Injury drug therapy Reperfusion Injury prevention & control Reperfusion Injury metabolism Neuroprotective Agents pharmacology Neuroprotective Agents therapeutic use Neuroprotective Agents metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Ethnopharmacol] 2024 Mar 25; Vol. 322, pp. 117672. <i>Date of Electronic Publication: </i>2023 Dec 28. MeSH Terms: Stroke* / drug therapy ; Brain Ischemia* / metabolism ; Metabolic Diseases* / drug therapy ; Reperfusion Injury* / drug therapy ; Reperfusion Injury* / prevention & control ; Reperfusion Injury* / metabolism ; Neuroprotective Agents* / pharmacology ; Neuroprotective Agents* / therapeutic use ; Neuroprotective Agents* / metabolism ; Rats ; Animals ; Sirtuin 1 / metabolism ; Brain ; Infarction, Middle Cerebral Artery / pathology Contributed Indexing: Keywords: Ischemic stroke; Naoxinqing; Nerve regeneration; Traditional Chinese medicine Substance Nomenclature: EC 3.5.1.- (Sirtuin 1) ; 0 (Neuroprotective Agents) Entry Date(s): Date Created: 20231230 Date Completed: 20240115 Latest Revision: 20240115 Update Code: 20240115

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