Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594.
In: The Journal of antibiotics, Jg. 77 (2024-03-01), Heft 3, S. 147
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Zugriff:
Talcarpones A (1) and B (2) are rare bisnaphthazarin derivatives produced by Talaromyces johnpittii (ex-type strain MST-FP2594), a newly discovered Australian fungus, which is formally described and named herein. The talcarpones were isolated along with the previously reported monomeric naphthoquinone, aureoquinone (3), suggesting a biosynthetic link between these metabolites. Talcarpone A is a lower homologue of hybocarpone (4), which was first isolated from a mycobiont of the lichen Lecanora hybocarpa. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis, molecular modelling and comparison with literature data. Talcarpones 1 and 2 exhibited moderate antifungal activity (MIC 0.78-3.1 µg ml -1 ) and weak activity against Gram-positive bacteria (MIC 13-25 µg ml -1 ). The talcarpones also demonstrated noteworthy chemical reactivities, with 2 converting rapidly to 1, which in turn converted slowly to the highly coloured 3. These post-biosynthetic reactions point to a potential ecological role for the talcarpones in providing ongoing (slow-release) physicochemical protection for T. johnpittii against solar irradiation.
(© 2023. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)
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Talcarpones A and B: bisnaphthazarin-derived metabolites from the Australian fungus Talaromyces johnpittii sp. nov. MST-FP2594.
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Autor/in / Beteiligte Person: | Lacey, AE ; Minns, SA ; Chen, R ; Vuong, D ; Lacey, E ; Kalaitzis, JA ; Tan, YP ; Shivas, RG ; Butler, MS ; Piggott, AM |
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Zeitschrift: | The Journal of antibiotics, Jg. 77 (2024-03-01), Heft 3, S. 147 |
Veröffentlichung: | 2009- : London : Nature Publishing Group ; <i>Original Publication</i>: Tokyo, Japan Antibiotics Research Assn., 2024 |
Medientyp: | academicJournal |
ISSN: | 1881-1469 (electronic) |
DOI: | 10.1038/s41429-023-00688-x |
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