Einzeltreffer — DigiBib

Six undescribed compounds, uvarirufols D and E, (+)-uvarigranol B, (-)-uvarigranol E, 6-acetoxy-5-hydroxy-7-methoxyflavanone and cherrevenaphthalene D, along with twelve known compounds, including polyoxygenated cyclohexenes, flavonoids, and lignans, were isolated from the methanol extract of Uvaria rufa stems. Their structures were elucidated by spectroscopic analyses and the absolute configurations were determined using electronic circular dichroism. Several isolates were evaluated for cytotoxic, antitubercular and anti-inflammatory potentials. (-)-6-Acetylzeylenol showed moderate inhibitory activity against Mycobacterium tuberculosis, with MIC value of 47.10 μg/mL. Cherrevenaphthalene D exhibited weak antimycobacterial activity and potent inhibitory effect on lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells (EC 50 = 8.54 μM). 8-Hydroxy-5,7-dimethoxyflavanone displayed moderate level of NO inhibition (EC 50 = 43.62 μM) with little cytotoxicity. The polyoxygenated cyclohexenes and lignans were inactive against HCT 116 and 22Rv1 cancer cells (IC 50 > 100 μM).

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem.
Autor/in / Beteiligte Person:	Gurgul, A ; Wu, Z ; Han, KY ; Shetye, G ; Sydara, K ; Souliya, O ; Johnson, JJ ; Che, CT
Link:	Zum Volltext
Zeitschrift:	Phytochemistry, Jg. 216 (2023-12-01), S. 113884
Veröffentlichung:	2003- : London : Elsevier ; <i>Original Publication</i>: 1961-2003: Oxford : Pergamon Press., 2023
Medientyp:	academicJournal
ISSN:	1873-3700 (electronic)
DOI:	10.1016/j.phytochem.2023.113884
Schlagwort:	Molecular Structure Cyclohexenes pharmacology Cyclohexenes chemistry Uvaria chemistry Lignans pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Phytochemistry] 2023 Dec; Vol. 216, pp. 113884. <i>Date of Electronic Publication: </i>2023 Oct 07. MeSH Terms: Uvaria* / chemistry ; Lignans* / pharmacology ; Molecular Structure ; Cyclohexenes / pharmacology ; Cyclohexenes / chemistry References: Nat Prod Res. 2015 Feb;29(3):247-52. (PMID: 25338140) ; J Ethnopharmacol. 2014 Feb 3;151(2):903-11. (PMID: 24333958) ; Biochem Pharmacol. 1999 Sep 1;58(5):759-65. (PMID: 10449184) ; Inflammopharmacology. 2007 Dec;15(6):252-9. (PMID: 18236016) ; Carbohydr Res. 2021 Nov;509:108432. (PMID: 34530378) ; Asian Pac J Trop Med. 2012 Oct;5(10):777-80. (PMID: 23043915) ; J Chromatogr A. 2006 Apr 21;1112(1-2):31-63. (PMID: 16480997) ; Methods Mol Biol. 2015;1285:281-92. (PMID: 25779323) ; J Nat Prod. 2021 Jan 22;84(1):20-25. (PMID: 33415978) ; Molecules. 2013 May 08;18(5):5265-87. (PMID: 23698042) ; Phytochemistry. 2007 Jun;68(11):1579-86. (PMID: 17493646) ; J Nat Prod. 2017 Dec 22;80(12):3319-3323. (PMID: 29172496) ; Fitoterapia. 2000 Jun;71(3):328-30. (PMID: 10844174) ; J Nat Prod. 2017 Jan 27;80(1):114-125. (PMID: 28001067) ; Biochem Biophys Res Commun. 2017 Jan 29;483(1):674-679. (PMID: 27986566) ; Fitoterapia. 2019 Oct;138:104340. (PMID: 31465816) ; Chem Commun (Camb). 2014 Oct 18;50(81):12076-9. (PMID: 25163506) ; Bioorg Med Chem Lett. 2017 Oct 15;27(20):4765-4769. (PMID: 28911817) ; J Nat Prod. 2012 Jun 22;75(6):1177-83. (PMID: 22676269) ; Yao Xue Xue Bao. 1997 Jul;32(7):530-5. (PMID: 11596279) ; Fitoterapia. 2018 Jun;127:420-424. (PMID: 29398201) ; Cancer Res. 1987 Feb 15;47(4):943-6. (PMID: 3802101) ; PLoS One. 2017 Jan 6;12(1):e0168945. (PMID: 28060845) ; Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0028221. (PMID: 34097493) ; Phytochemistry. 2022 Oct;202:113298. (PMID: 35780925) ; J Agric Food Chem. 2001 Jun;49(6):2788-98. (PMID: 11409967) ; ACS Pharmacol Transl Sci. 2021 Jun 04;4(4):1437-1448. (PMID: 34423275) ; Phytochemistry. 2022 Sep;201:113276. (PMID: 35714737) ; Fitoterapia. 2022 Apr;158:105170. (PMID: 35288209) ; Fitoterapia. 2017 Jul;120:103-107. (PMID: 28596029) ; J Ethnopharmacol. 2016 Dec 24;194:483-494. (PMID: 27732901) ; J Nat Prod. 2020 Apr 24;83(4):996-1004. (PMID: 32155073) ; Molecules. 2010 Nov 05;15(11):7933-45. (PMID: 21060300) ; Nat Prod Res. 2022 Dec;36(23):6039-6043. (PMID: 35176917) Grant Information: R37 CA227101 United States CA NCI NIH HHS Contributed Indexing: Keywords: Annonaceae; Anti-inflammatory; Antimycobacterial; Cytotoxicity; Polyoxygenated cyclohexenes; Uvaria rufa Substance Nomenclature: 12L0P8F7GN (cyclohexene) ; 0 (Cyclohexenes) ; 0 (Lignans) Entry Date(s): Date Created: 20231009 Date Completed: 20231106 Latest Revision: 20240206 Update Code: 20240206 PubMed Central ID: PMC10841530

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem.