AGREE and ESA for Greenness Assessment of a Novel Validated RP-HPLC Method for Simultaneous Determination of Aspirin, Warfarin and Clopidogrel in Rat Plasma: Application to Pharmacokinetic Study of the Possible Interaction between the Three Drugs.

AlSawy, NS ; ElKady, EF ; et al.

In: Journal of chromatographic science, Jg. 62 (2024-04-23), Heft 4, S. 380-389

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The green profile of the developed method is assessed and compared with previously reported methods. Percutaneous coronary intervention is a procedure where a catheter is utilized to place a stent in order to facilitate opening of the blood vessels in the heart. Triple antithrombotic therapy includes oral anticoagulation as warfarin and dual antiplatelet therapy (composed of aspirin and clopidogrel bisulfate). The aim of the current study was to evaluate the pharmacokinetic parameters of ASP, WAR and CLP and to investigate the possible interaction between the three drugs upon co-administration in rats. A selective and precise RP-HPLC method was developed for the simultaneous determination of ASP, WAR and CLP in rat plasma. Pharmacokinetic study was conducted in rats that received ASP, WAR and CLP as an application of the developed method. From the statistical evaluation of the pharmacokinetic parameters, it was observed that the co-administration of ASP, WAR and CLP significantly increased the ASP and CLP bioavailability in rats. A significant drug-drug interaction was confirmed in the current study. The elevated Cmax of ASP and CLP upon the co-administration of ASP, WAR and CLP may explain the reported bleeding.

Titel:	AGREE and ESA for Greenness Assessment of a Novel Validated RP-HPLC Method for Simultaneous Determination of Aspirin, Warfarin and Clopidogrel in Rat Plasma: Application to Pharmacokinetic Study of the Possible Interaction between the Three Drugs.
Autor/in / Beteiligte Person:	AlSawy, NS ; ElKady, EF ; Mostafa, EA
Link:	Zum Volltext
Zeitschrift:	Journal of chromatographic science, Jg. 62 (2024-04-23), Heft 4, S. 380-389
Veröffentlichung:	<2012- > : Oxford : Oxford University Press ; <i>Original Publication</i>: Niles Il : Preston Technical Abstracts, 2024
Medientyp:	academicJournal
ISSN:	1945-239X (electronic)
DOI:	10.1093/chromsci/bmad078
Schlagwort:	Animals Chromatography, High Pressure Liquid methods Rats Male Reproducibility of Results Chromatography, Reverse-Phase methods Linear Models Limit of Detection Green Chemistry Technology methods Rats, Sprague-Dawley Platelet Aggregation Inhibitors pharmacokinetics Platelet Aggregation Inhibitors blood Platelet Aggregation Inhibitors chemistry Anticoagulants pharmacokinetics Anticoagulants blood Anticoagulants chemistry Warfarin pharmacokinetics Warfarin blood Warfarin chemistry Aspirin pharmacokinetics Aspirin blood Aspirin chemistry Clopidogrel pharmacokinetics Clopidogrel blood Clopidogrel chemistry Drug Interactions
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Chromatogr Sci] 2024 Apr 23; Vol. 62 (4), pp. 380-389. MeSH Terms: Warfarin* / pharmacokinetics ; Warfarin* / blood ; Warfarin* / chemistry ; Aspirin* / pharmacokinetics ; Aspirin* / blood ; Aspirin* / chemistry ; Clopidogrel* / pharmacokinetics ; Clopidogrel* / blood ; Clopidogrel* / chemistry ; Drug Interactions* ; Animals ; Chromatography, High Pressure Liquid / methods ; Rats ; Male ; Reproducibility of Results ; Chromatography, Reverse-Phase / methods ; Linear Models ; Limit of Detection ; Green Chemistry Technology / methods ; Rats, Sprague-Dawley ; Platelet Aggregation Inhibitors / pharmacokinetics ; Platelet Aggregation Inhibitors / blood ; Platelet Aggregation Inhibitors / chemistry ; Anticoagulants / pharmacokinetics ; Anticoagulants / blood ; Anticoagulants / chemistry Comments: Erratum in: J Chromatogr Sci. 2023 Oct 31;:. (PMID: 37930728) Substance Nomenclature: 5Q7ZVV76EI (Warfarin) ; R16CO5Y76E (Aspirin) ; A74586SNO7 (Clopidogrel) ; 0 (Platelet Aggregation Inhibitors) ; 0 (Anticoagulants) Entry Date(s): Date Created: 20231004 Date Completed: 20240426 Latest Revision: 20240426 Update Code: 20240426

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