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Introduction: The health impact from alcohol is of recognised concern, from acute intoxication as well as increased risk of chronic health issues over time. Identifying factors associated with higher alcohol consumption when presenting to the emergency department (ED) will inform public health policy and enable more targeted health care and appropriate referrals.

Methods: Secondary testing of blood samples collected during routine clinical care of 1160 ED patients presenting to the Royal Brisbane and Women's Hospital in Queensland, Australia, for 10 days between 22 January and 1 February 2021. Alcohol was measured by blood ethanol (intake in recent hours) and phosphatidylethanol (PEth; intake over 2-4 weeks). Zero-inflated negative binomial regression was used to identify demographic and clinical factors associated with higher alcohol concentrations.

Results: Males were found to have 83% higher blood ethanol and 32% higher PEth concentrations than females (adjusted rate ratio [ARR] 1.83, 95% confidence interval [CI] 1.37-2.45 and ARR 1.32, 95% CI 1.04-1.68, respectively). Blood ethanol concentrations were 3.4 times higher for those 18-44 years, compared to those aged 65+ (ARR 3.40, 95% CI 2.40-4.82) whereas PEth concentrations were found to be the highest in those aged 45-64 years, being 70% higher than those aged 65+ (ARR 1.70, 95% CI 1.19-2.44). Patients brought in involuntarily had eight-times higher blood ethanol concentrations than those who self-attended.

Discussion and Conclusions: This study used two alcohol markers to identify factors associated with higher alcohol concentrations in emergency presentations. The findings demonstrate how these biomarkers can provide informative data for public health responses and monitoring of alcohol use trends.

Titel:	Factors associated with higher alcohol concentrations in emergency department presentations: PACE study.
Autor/in / Beteiligte Person:	Cameron, CM ; Vuong, K ; McWhinney, B ; Zournazi, A ; Manzanero, S ; Warren, J ; Mitchell, G ; Vallmuur, K ; Howell, T ; Ungerer, JPJ
Link:	Zum Volltext
Zeitschrift:	Drug and alcohol review, Jg. 42 (2023-11-01), Heft 7, S. 1796-1806
Veröffentlichung:	<Mar. 2009-: Richmond, Vic. : Wiley-Blackwell ; <i>Original Publication</i>: Abingdon, Oxfordshire, U.K. : Carfax Pub. Co.,, 2023
Medientyp:	academicJournal
ISSN:	1465-3362 (electronic)
DOI:	10.1111/dar.13744
Schlagwort:	Male Humans Female Emergency Service, Hospital Australia Queensland epidemiology Blood Alcohol Content Biomarkers Ethanol Alcohol Drinking epidemiology
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Phosphatidylethanol levels, as a marker of alcohol consumption, are associated with risk of intracerebral hemorrhage. Stroke. 2020;51:2148-2152. ; Luginbuhl M, Stoth F, Schrock A, Gaugler S, Weinmann W. Quantitative determination of phosphatidylethanol in dried blood spots for monitoring alcohol abstinence. Nat Protoc. 2021;16:283-308. Contributed Indexing: Keywords: alcohol; emergency service; epidemiology; hospital; risk factors Substance Nomenclature: 3K9958V90M (Ethanol) ; 0 (Blood Alcohol Content) ; 0 (Biomarkers) Entry Date(s): Date Created: 20230913 Date Completed: 20231113 Latest Revision: 20231114 Update Code: 20231215

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Factors associated with higher alcohol concentrations in emergency department presentations: PACE study.