Intralesional measles, mumps, and rubella vaccine after failure of intralesional Candida antigen for the treatment of recalcitrant pediatric warts.

Ulschmid, CM ; Patel, J ; et al.

In: Pediatric dermatology, Jg. 40 (2023-11-01), Heft 6, S. 1057-1059

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Numerous studies have investigated the efficacy of intralesional immunotherapy for warts, but there are a lack of studies investigating the efficacy of alternative intralesional immunotherapies following failure of initial intralesional immunotherapy. In this retrospective study, we aimed to investigate the efficacy of intralesional measles, mumps, and rubella vaccine for the treatment of pediatric warts following failure of intralesional therapy with Candida antigen. Following intralesional measles, mumps, and rubella vaccine administration, 8/51 (15.5%) patients had complete resolution of their warts, 6/51 (12%) had near complete resolution, 19/51 (37%) had partial improvement, 12/51 (23.5%) had no change, and 6/51 (12%) had worsening. Although limited by retrospective nature and low sample size, our results demonstrate that intralesional immunotherapy with measles, mumps, and rubella vaccine provides an alternative therapeutic option for the treatment of recalcitrant pediatric warts in patients who fail to respond to intralesional Candida antigen.

Titel:	Intralesional measles, mumps, and rubella vaccine after failure of intralesional Candida antigen for the treatment of recalcitrant pediatric warts.
Autor/in / Beteiligte Person:	Ulschmid, CM ; Patel, J ; Pan, AY ; Liegl, M ; Holland, KE
Link:	Zum Volltext
Zeitschrift:	Pediatric dermatology, Jg. 40 (2023-11-01), Heft 6, S. 1057-1059
Veröffentlichung:	<2010->: Hoboken, NJ : Wiley ; <i>Original Publication</i>: [Boston, MA] : Blackwell Scientific Publications, [1983-, 2023
Medientyp:	academicJournal
ISSN:	1525-1470 (electronic)
DOI:	10.1111/pde.15415
Schlagwort:	Humans Child Retrospective Studies Rubella Vaccine Immunotherapy methods Antigens, Fungal therapeutic use Injections, Intralesional Candida Treatment Outcome Measles-Mumps-Rubella Vaccine therapeutic use Mumps drug therapy Warts drug therapy Measles drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pediatr Dermatol] 2023 Nov-Dec; Vol. 40 (6), pp. 1057-1059. <i>Date of Electronic Publication: </i>2023 Aug 19. MeSH Terms: Mumps* / drug therapy ; Warts* / drug therapy ; Measles* / drug therapy ; Humans ; Child ; Retrospective Studies ; Rubella Vaccine ; Immunotherapy / methods ; Antigens, Fungal / therapeutic use ; Injections, Intralesional ; Candida ; Treatment Outcome ; Measles-Mumps-Rubella Vaccine / therapeutic use References: Fields JR, Saikaly SK, Schoch JJ. Intralesional immunotherapy for pediatric warts: a review. Pediatr Dermatol. 2020;37(2):265-271. ; Alikhan A, Griffin JR, Newman CC. Use of Candida antigen injections for the treatment of verruca vulgaris: a two-year mayo clinic experience. J Dermatolog Treat. 2016;27(4):355-358. ; Johnson SM, Roberson PK, Horn TD. Intralesional injection of mumps or Candida skin test antigens: a novel immunotherapy for warts. Arch Dermatol. 2001;137(4):451-455. ; Na CH, Choi H, Song SH, Kim MS, Shin BS. Two-year experience of using the measles, mumps and rubella vaccine as intralesional immunotherapy for warts. Clin Exp Dermatol. 2014;39(5):583-589. ; Zamanian A, Mobasher P, Jazi GA. Efficacy of intralesional injection of mumps-measles-rubella vaccine in patients with wart. Adv Biomed Res. 2014;31(3):107. ; Mohta A, Kushwaha RK, Gautam U, Sharma P, Nyati A, Jain SK. A comparative study of the efficacy and safety of intralesional measles, mumps, and rubella vaccine versus intralesional vitamin D3 for the treatment of warts in children. Pediatr Dermatol. 2020;37(5):853-859. ; Shaheen MA, Salem SA, Fouad DA, El-Fatah AA. Intralesional tuberculin (PPD) versus measles, mumps, rubella (MMR) vaccine in treatment of multiple warts: a comparative clinical and immunological study. Dermatol Ther. 2015;28(4):194-200. ; Signore RJ. Candida albicans intralesional injection immunotherapy of warts. Cutis. 2002;70:185-192. Contributed Indexing: Keywords: immunotherapy; pediatrics; retrospective studies; warts Substance Nomenclature: 0 (Rubella Vaccine) ; 0 (Antigens, Fungal) ; 0 (Measles-Mumps-Rubella Vaccine) Entry Date(s): Date Created: 20230819 Date Completed: 20231117 Latest Revision: 20231117 Update Code: 20231215

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