Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp.
In: Journal of natural products, Jg. 86 (2023-08-25), Heft 8, S. 2054-2058
Online
academicJournal
Zugriff:
Turonicin A ( 1 ) was isolated from Streptomyces sp. MST-123921, which was recovered from soil collected on the banks of the Turon River in New South Wales, Australia. Turonicin A ( 1 ) is an amphoteric linear polyene polyketide featuring independent pentaene and tetraenone chromophores and is structurally related to linearmycins A-C ( 2 - 4 ). The structure of 1 was determined by detailed spectroscopic analysis and comparison to literature data. Bioinformatic analysis of the linearmycin biosynthetic gene cluster also allowed the previously unresolved absolute stereostructures of 2 - 4 to be elucidated. Turonicin A ( 1 ) exhibited very potent activity against the fungi Candida albicans (MIC 0.0031 μg/mL, 2.7 nM) and Saccharomyces cerevisiae (MIC 0.0008 μg/mL, 0.7 nM), moderate activity against the bacteria Bacillus subtilis (MIC 0.097 μg/mL, 85 nM) and Staphylococcus aureus (MIC 0.39 μg/mL, 340 nM), and no cytotoxicity against human fibroblasts, making it an attractive candidate for further development as a potential next-generation antibiotic scaffold.
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Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp.
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Autor/in / Beteiligte Person: | Chen, R ; Minns, SA ; Kalaitzis, JA ; Butler, MS ; Rosin, M ; Vuong, D ; Lean, SS ; Chooi, YH ; Lacey, E ; Piggott, AM |
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Zeitschrift: | Journal of natural products, Jg. 86 (2023-08-25), Heft 8, S. 2054-2058 |
Veröffentlichung: | Cincinnati, American Society of Pharmacognosy., 2023 |
Medientyp: | academicJournal |
ISSN: | 1520-6025 (electronic) |
DOI: | 10.1021/acs.jnatprod.3c00144 |
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