SARS-CoV-2 seroprevalence among blood donors in Uganda: 2019-2022.
In: Transfusion, Jg. 63 (2023-07-01), Heft 7, S. 1354-1365
Online
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Zugriff:
Background: The true burden of COVID-19 in low- and middle-income countries remains poorly characterized, especially in Africa. Even prior to the availability of SARS-CoV-2 vaccines, countries in Africa had lower numbers of reported COVID-19 related hospitalizations and deaths than other regions globally.
Methods: Ugandan blood donors were evaluated between October 2019 and April 2022 for IgG antibodies to SARS-CoV-2 nucleocapsid (N), spike (S), and five variants of the S protein using multiplexed electrochemiluminescence immunoassays (MesoScale Diagnostics, Rockville, MD). Seropositivity for N and S was assigned using manufacturer-provided cutoffs and trends in seroprevalence were estimated by quarter. Statistically significant associations between N and S antibody seropositivity and donor characteristics in November-December 2021 were assessed by chi-square tests.
Results: A total of 5393 blood unit samples from donors were evaluated. N and S seropositivity increased throughout the pandemic to 82.6% in January-April 2022. Among seropositive individuals, N and S antibody levels increased ≥9-fold over the study period. In November-December 2021, seropositivity to N and S antibody was higher among repeat donors (61.3%) compared with new donors (55.1%; p = .043) and among donors from Kampala (capital city of Uganda) compared with rural regions (p = .007). Seropositivity to S antibody was significantly lower among HIV-seropositive individuals (58.8% vs. 84.9%; p = .009).
Conclusions: Despite previously reported low numbers of COVID-19 cases and related deaths in Uganda, high SARS-CoV-2 seroprevalence and increasing antibody levels among blood donors indicated that the country experienced high levels of infection over the course of the pandemic.
(© 2023 AABB.)
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SARS-CoV-2 seroprevalence among blood donors in Uganda: 2019-2022.
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Autor/in / Beteiligte Person: | Bloch, EM ; Kyeyune, D ; White, JL ; Ddungu, H ; Ashokkumar, S ; Habtehyimer, F ; Baker, O ; Kasirye, R ; Patel, EU ; Grabowski, MK ; Musisi, E ; Moses, K ; Hume, HA ; Lubega, I ; Shrestha, R ; Motevalli, M ; Fernandez, RE ; Reynolds, SJ ; Redd, AD ; Wambongo Musana, H ; Dhabangi, A ; Ouma, J ; Eroju, P ; de Lange T ; Fowler, MG ; Musoke, P ; Stramer, SL ; Whitby, D ; Zimmerman, PA ; McCullough, J ; Sachithanandham, J ; Pekosz, A ; Goodrich, R ; Quinn, TC ; Ness, PM ; Laeyendecker, O ; Tobian, AAR |
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Zeitschrift: | Transfusion, Jg. 63 (2023-07-01), Heft 7, S. 1354-1365 |
Veröffentlichung: | Arlington, Va. : American Association Of Blood Banks, 2023 |
Medientyp: | academicJournal |
ISSN: | 1537-2995 (electronic) |
DOI: | 10.1111/trf.17449 |
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