Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β-(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights.
In: The Journal of organic chemistry, Jg. 88 (2023-06-02), Heft 11, S. 6857-6867
Online
academicJournal
Zugriff:
Experimental results and computational insights explain the key role of transition-metal catalysis/Brønsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/cyclocondensation reactions of β-(2-aminophenyl)-α,β-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline-(hetero)aromatic hybrids. The first approach to the synthesis of 4-(1 H -pyrrol-2-yl)quinolines is described. The effectiveness of various transition metals is compared.
| Titel: |
Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β-(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights.
|
|---|---|
| Autor/in / Beteiligte Person: | Marsicano, V ; Arcadi, A ; Aschi, M ; Chiarini, M ; Fabrizi, G ; Goggiamani, A ; Marinelli, F ; Iazzetti, A |
| Link: | |
| Zeitschrift: | The Journal of organic chemistry, Jg. 88 (2023-06-02), Heft 11, S. 6857-6867 |
| Veröffentlichung: | Columbus Oh : American Chemical Society ; <i>Original Publication</i>: Easton, Pa. [etc.], 2023 |
| Medientyp: | academicJournal |
| ISSN: | 1520-6904 (electronic) |
| DOI: | 10.1021/acs.joc.3c00137 |
| Sonstiges: |
|