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Introduction: Mycosis fungoides (MF) and Sezary Syndrome are the most common forms of cutaneous T-cell lymphoma. Early-stage MF is known to have an indolent behavior, and the EORTC guidelines recommend treating patients with skin-directed therapies, such as phototherapy, instead of systemic therapies. Phototherapy is a popular therapeutic option, with two commonly used light sources-PUVA and narrow band-nb UVB. PUVA is less commonly used due to its potential carcinogenic role, but it has systemic effects, while nb-UVB has mostly skin-limited effects. There is ongoing debate regarding the role of UVB light, and in 2021, the Cutaneous Lymphoma Italian Study Group reached a consensus on technical schedules for NB-UVB and PUVA for MF. This study aims to analyze and compare the efficacy of the two phototherapy options in treating early-MF patients.

Materials and Methods: The study included patients diagnosed with stage IA/B MF in the last 10 years, who had at least 12 months of follow-up data and a minimum of 24 phototherapy sessions (PUVA or nb UVB) and treated with topical steroids apart from phototherapy.

Results: Results showed that the two phototherapy options were similarly effective in treating early MF, with no significant differences in clinical response, although PUVA was associated with more adverse effects.

Conclusions: The study provides valuable insights into the use of phototherapy in early MF, and the results can be used to guide treatment decisions and improve patient outcomes.

Titel:	Nb-UVB and PUVA therapy in treating early stages of Mycosis Fungoides: A single-center cross-sectional study.
Autor/in / Beteiligte Person:	Zengarini, C ; Baruffaldi, G ; Piraccini, BM ; Bardazzi, F ; Mussi, M ; Hrvatin Stancic, B ; Pileri, A
Link:	Zum Volltext
Zeitschrift:	Photodermatology, photoimmunology & photomedicine, Jg. 39 (2023-09-01), Heft 5, S. 435-440
Veröffentlichung:	<2010-> : Oxford : Blackwell ; <i>Original Publication</i>: Copenhagen : Munksgaard, c1990-, 2023
Medientyp:	academicJournal
ISSN:	1600-0781 (electronic)
DOI:	10.1111/phpp.12873
Schlagwort:	Humans Cross-Sectional Studies Treatment Outcome PUVA Therapy methods Mycosis Fungoides drug therapy Mycosis Fungoides radiotherapy Skin Neoplasms drug therapy Skin Neoplasms radiotherapy Lymphoma, T-Cell, Cutaneous Ultraviolet Therapy methods
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J Eur Acad Dermatol Venereol. 2006;20(5):542-547. doi:10.1111/j.1468-3083.2006.01531.x. ; Brazzelli V, Antoninetti M, Palazzini S, Prestinari F, Borroni G. Narrow-band ultraviolet therapy in early-stage Mycosis Fungoides: study on 20 patients. Photodermatol Photoimmunol Photomed. 2007;23(6):229-233. doi:10.1111/j.1600-0781.2007.00314.x. Grant Information: Ministero della Salute Contributed Indexing: Keywords: MF; Mycosis Fungoides; PUVA; T-cell; cancer; lymphoma; nb-UVB; phototherapy; skin; tumor Entry Date(s): Date Created: 20230328 Date Completed: 20230918 Latest Revision: 20230918 Update Code: 20231215

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Nb-UVB and PUVA therapy in treating early stages of Mycosis Fungoides: A single-center cross-sectional study.