Ameliorating age-dependent effects of resveratrol on VPA-induced social impairments and anxiety-like behaviors in a rat model of neurodevelopmental disorder.

Shahrbabaki, SSV ; Moslemizadeh, A ; et al.

In: Neurotoxicology, Jg. 96 (2023-05-01), S. 154

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Although anxiety disorders, as well as difficulties in social interaction, are documented in children with autism spectrum disorder (ASD) as a neurodevelopmental disorder, the effectiveness of potential therapeutic procedures considering age and sex differences is under serious discussion. The present study aimed to investigate the effect of resveratrol (RSV) on anxiety-like behaviors and social interaction in juvenile and adult rats of both sex in a valproic acid (VPA)-induced autistic-like model. Prenatal exposure to VPA was associated with increased anxiety, also causing a significant reduction in social interaction in juvenile male subjects. Further administration of RSV attenuated VPA-induced anxiety symptoms in both sexes of adult animals and significantly increased the sociability index in male and female juvenile rats. Taken together, it can be concluded that treatment with RSV can attenuate some of the harsh effects of VPA. This treatment was especially effective on anxiety-like traits in adult subjects of both sexes regarding their performance in open field and EPM. We encourage future research to consider the sex and age-specific mechanisms behind the RSV treatment in the prenatal VPA model of autism.

Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hamideh Bashiri reports administrative support, article publishing charges, equipment, drugs, or supplies, statistical analysis, travel, and writing assistance were provided by Kerman University of Medical Sciences. Hamideh Bashiri reports a relationship with Kerman University of Medical Sciences that includes: board membership, employment, and non-financial support. Hamideh Bashiri has patent pending to None. The author declare that there is no conflict of interest.

Titel:	Ameliorating age-dependent effects of resveratrol on VPA-induced social impairments and anxiety-like behaviors in a rat model of neurodevelopmental disorder.
Autor/in / Beteiligte Person:	Shahrbabaki, SSV ; Moslemizadeh, A ; Amiresmaili, S ; Tezerji, SS ; Juybari, KB ; Sepehri, G ; Shamsi Meymandi, M ; Bashiri, H
Link:	Zum Volltext
Zeitschrift:	Neurotoxicology, Jg. 96 (2023-05-01), S. 154
Veröffentlichung:	2001- : Amsterdam : Elsevier Science ; <i>Original Publication</i>: Park Forest South, Ill., Pathotox Publishers., 2023
Medientyp:	academicJournal
ISSN:	1872-9711 (electronic)
DOI:	10.1016/j.neuro.2023.03.003
Schlagwort:	Pregnancy Humans Rats Female Male Animals Valproic Acid adverse effects Resveratrol pharmacology Anxiety chemically induced Anxiety drug therapy Disease Models, Animal Social Behavior Behavior, Animal Autism Spectrum Disorder chemically induced Autism Spectrum Disorder drug therapy Prenatal Exposure Delayed Effects chemically induced
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Neurotoxicology] 2023 May; Vol. 96, pp. 154-165. <i>Date of Electronic Publication: </i>2023 Mar 16. MeSH Terms: Autism Spectrum Disorder* / chemically induced ; Autism Spectrum Disorder* / drug therapy ; Prenatal Exposure Delayed Effects* / chemically induced ; Pregnancy ; Humans ; Rats ; Female ; Male ; Animals ; Valproic Acid / adverse effects ; Resveratrol / pharmacology ; Anxiety / chemically induced ; Anxiety / drug therapy ; Disease Models, Animal ; Social Behavior ; Behavior, Animal Contributed Indexing: Keywords: Age; Anxiety-like behavior; Autistic-like behaviors; Gender; Resveratrol; Social interaction; Valproic acid Substance Nomenclature: 614OI1Z5WI (Valproic Acid) ; Q369O8926L (Resveratrol) Entry Date(s): Date Created: 20230318 Date Completed: 20230519 Latest Revision: 20230521 Update Code: 20240513

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