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Purpose: Atherosclerosis (AS) is a cardiovascular disease that has become a major threat to public health worldwide. This study aims to elucidate the effect and mechanism of icariin (ICA) in treating atherosclerosis.

Methods: ApoE -/- mouse AS modeling, ELISA, and hematoxylin-eosin staining were conducted to explore whether icariin has a therapeutic effect on AS. The microRNA (miRNA) chips for ICA treatment of ApoE-/- AS mice were developed; in silico analyses were performed, and signaling pathways were identified. Oxidized low-density lipoprotein (Ox-LDL) was used to induce human aortic vascular smooth muscle cells (HAVSMCs) to build an in vitro AS cell model. Moreover, miR-205-5p was silenced. Finally, cell viability was detected by MTT assay, cell apoptosis by flow cytometry and Western blot, and cell migration by the scratch test.

Results: ICA could reduce lipid accumulation in the blood vessels of mice and plaque formation to treat AS. ICA promoted apoptosis and inhibited cell migration of HAVSMCs induced by ox-LDL. Moreover, cell proliferation and migration were inhibited via ICA, which was restored by miR-205-5p silencing.

Conclusion: ICA can alleviate AS and inhibit the proliferation and migration of HAVSMCs induced by ox-LDL, potentially mediated by the upregulation of miR-205-5p.

Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Icariin alleviates atherosclerosis by regulating the miR-205-5p/ERBB4/AKT signaling pathway.
Autor/in / Beteiligte Person:	Huang, P ; Wang, F ; Zhang, Y ; Qin, M ; Ji, J ; Wei, D ; Ren, L
Link:	Zum Volltext
Zeitschrift:	International immunopharmacology, Jg. 114 (2023), S. 109611
Veröffentlichung:	Amsterdam ; New York : Elsevier Science, c2001-, 2023
Medientyp:	academicJournal
ISSN:	1878-1705 (electronic)
DOI:	10.1016/j.intimp.2022.109611
Schlagwort:	Humans Proto-Oncogene Proteins c-akt metabolism Signal Transduction Apoptosis Cell Proliferation Apolipoproteins E Lipoproteins, LDL metabolism Receptor, ErbB-4 metabolism Receptor, ErbB-4 pharmacology MicroRNAs metabolism Atherosclerosis metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int Immunopharmacol] 2023 Jan; Vol. 114, pp. 109611. <i>Date of Electronic Publication: </i>2022 Dec 21. MeSH Terms: MicroRNAs* / metabolism ; Atherosclerosis* / metabolism ; Humans ; Proto-Oncogene Proteins c-akt / metabolism ; Signal Transduction ; Apoptosis ; Cell Proliferation ; Apolipoproteins E ; Lipoproteins, LDL / metabolism ; Receptor, ErbB-4 / metabolism ; Receptor, ErbB-4 / pharmacology Contributed Indexing: Keywords: Atherosclerosis; Human aortic vascular smooth muscle cells; Icariin; miR-205-5p; miR-205-5p/ERBB4/AKT Substance Nomenclature: EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) ; VNM47R2QSQ (icariin) ; 0 (MicroRNAs) ; 0 (Apolipoproteins E) ; 0 (Lipoproteins, LDL) ; EC 2.7.10.1 (ERBB4 protein, human) ; EC 2.7.10.1 (Receptor, ErbB-4) ; 0 (MIRN205 microRNA, human) Entry Date(s): Date Created: 20230126 Date Completed: 20230130 Latest Revision: 20230202 Update Code: 20240513

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Icariin alleviates atherosclerosis by regulating the miR-205-5p/ERBB4/AKT signaling pathway.