Zum Hauptinhalt springen

Hesperidin protects against aluminum-induced renal injury in rats via modulating MMP-9 and apoptosis: biochemical, histological, and ultrastructural study.

Hassan, NH ; Yousef, DM ; et al.
In: Environmental science and pollution research international, Jg. 30 (2023-03-01), Heft 13, S. 36208-36227
Online academicJournal

Titel:
Hesperidin protects against aluminum-induced renal injury in rats via modulating MMP-9 and apoptosis: biochemical, histological, and ultrastructural study.
Autor/in / Beteiligte Person: Hassan, NH ; Yousef, DM ; Alsemeh, AE
Link:
Zeitschrift: Environmental science and pollution research international, Jg. 30 (2023-03-01), Heft 13, S. 36208-36227
Veröffentlichung: <2013->: Berlin : Springer ; <i>Original Publication</i>: Landsberg, Germany : Ecomed, 2023
Medientyp: academicJournal
ISSN: 1614-7499 (electronic)
DOI: 10.1007/s11356-022-24800-0
Schlagwort:
  • Animals
  • Male
  • Aluminum Chloride
  • Apoptosis
  • Kidney physiology
  • Matrix Metalloproteinase 9
  • Oxidative Stress
  • Rats
  • Aluminum
  • Hesperidin pharmacology
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article
  • Language: English
  • [Environ Sci Pollut Res Int] 2023 Mar; Vol. 30 (13), pp. 36208-36227. <i>Date of Electronic Publication: </i>2022 Dec 22.
  • MeSH Terms: Aluminum* ; Hesperidin* / pharmacology ; Animals ; Male ; Aluminum Chloride ; Apoptosis ; Kidney / physiology ; Matrix Metalloproteinase 9 ; Oxidative Stress ; Rats
  • References: AbdAlsalam A, Elshaer FM, Mansour HA (2016) Assessment of the potential role of hesperidin as an antioxidant on the carbon tetrachloride-induced kidney damage in rats. Egyptian J Hosp Med 64(1):277–286. ; Abdel-Hamid GA (2013) Effect of vitamin E and selenium against aluminum-induced nephrotoxicity in pregnant rats. Folia Histochemica et Cytobiologica 51(4):312–319. https://doi.org/10.5603/FHC.2013.0042. (PMID: 10.5603/FHC.2013.0042) ; Aboismaiel MG, El-Mesery M, El-Karef A, El-Shishtawy MM (2020) Hesperetin upregulates Fas/FasL expression and potentiates the antitumor effect of 5-fluorouracil in rat model of hepatocellular carcinoma. Egyptian J Basic Appl Sci 7(1):20–34. ; Al Dera HS (2016) Protective effect of resveratrol against aluminum chloride induced nephrotoxicity in rats. Saudi Med J 37(4):369–378. https://doi.org/10.15537/smj.2016.4.13611. (PMID: 10.15537/smj.2016.4.13611) ; Al Eisa R, Al NH (2016) Protective effect of royal jelly against the liver toxicity caused by aluminum chloride (ALCL3) in adult male rats. Adv Environ Biol 10(3):113–127. ; Al Kahtani MA (2010) Renal damage mediated by oxidative stress in mice treated with aluminium chloride: protective effects of taurine. Biol Sci 10(7):584–595. ; Al Kahtani MA, Abdel-Moneim AM, El-Sayed WM (2014) The influence of taurine pretreatment on aluminum chloride induced nephrotoxicity in Swiss albino mice. Histol Histopathol. 29(1):45–55. https://doi.org/10.14670/HH-29.45. ; Al-Kahtani M, Morsy K (2019) Ameliorative effect of selenium nanoparticles against aluminum chloride-induced hepatorenal toxicity in rats. Environ Sci Pollut Res 26(31):32189–32197. https://doi.org/10.1007/s11356-019-06417-y. (PMID: 10.1007/s11356-019-06417-y) ; Al-Olayan EM, El-Khadragy MF, Abdel Moneim AE (2015) The protective properties of melatonin against aluminium-induced neuronal injury. Int J Exp Pathol 96(3):196–202. ; Aly MS, Galaly SR, Moustafa N, Mohammed HM, Khadrawy SM, Mahmoud AM (2017) Hesperidin protects against diethylnitrosamine/carbon tetrachloride-induced renal repercussions via up-regulation of Nrf2/HO-1 signaling and attenuation of oxidative stress. J Appl Pharm Sci 7(11):7–14. ; Anandan R, Subramanian P (2012) Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats. Redox Rep 17(5):219–26. ; Balakrishnan A, Menon VP (2007) Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity. Toxicology 238(2–3):90–98. ; Balgoon MJ (2019) Assessment of the protective effect of Lepidium sativum against aluminum-induced liver and kidney effects in albino rat. Biomed Res Int. https://doi.org/10.1155/2019/4516730. (PMID: 10.1155/2019/4516730) ; Catania JM, Chen G, Parrish AR (2007) Role of matrix metalloproteinases in renal pathophysiologies. Am J Physiol-Renal Physiol 292(3):F905–F911. ; Cho J (2006). Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin. Arch of Pharm Res 29(8):699–706. ; Dejonckheere E, Vandenbroucke RE, Libert C (2011) Matrix metalloproteinases as drug targets in ischemia/reperfusion injury. Drug Discov Today 16(17–18):762–778. ; Elhelaly AE, AlBasher G, Alfarraj S, Almeer R, Bahbah EI, Fouda M, Bungău SG, Aleya L, Abdel-Daim MM (2019) Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res 26(34):35151–62. ; Fatima ZT, Monya L, Nadia AH, Zineb T, Abdelkader A (2016) Protective effect of Haloxylon salicornicum on hepatic and renal functions of Wistar rats exposed to aluminium. Afr J Biotech 15(9):293–302. https://doi.org/10.5897/ajb2015.15037. (PMID: 10.5897/ajb2015.15037) ; Hanafy S, Soltan ME (2004) Effects of Vitamin E pretreatment on subacute toxicity of mixture of Co, Pb, and Hg nitrate-induced nephrotoxicity in rats. Environ Toxicol Pharmacol 17(3):159–167. ; Hanedan B, Ozkaraca M, Kirbas A, Kandemir FM, Aktas MS, Kilic K, Comakli S, Kucukler S, Bilgili A (2018) Investigation of the effects of hesperidin and chrysin on renal injury induced by colistin in rats. Biomed Pharmacother 108:1607–16. ; Hasona NA, Ahmed MQ (2017) Antioxidant and ameliorative effects of Zingiber officinale against aluminum chloride toxicity. Sci Int 5(3):96–104. https://doi.org/10.17311/sciintl.96.104. (PMID: 10.17311/sciintl.96.104) ; Imam TS, Khalifa HA, Hussein MMA, Ali HA (2016) Aluminum-induced oxidative stress and hepato-renal impairment in male albino rats: possible protective trial with naringenin. Life Sci J 13(1s). https://doi.org/10.7537/marslsj1301s1610. ; Jeon H, Seo M, Choi H, Lee O, Lee B (2014) Gelidium elegans, an edible red seaweed, and hesperidin inhibit lipid accumulation and production of reactive oxygen species and reactive nitrogen species in 3T3-L1 and RAW264. 7 cells. Phytother Res 28(11):1701–1709. ; Jeong CH, Kwon HC, Kim DH, Cheng WN, Kang S, Shin D-M, Yune JH, Yoon JE, Chang YH, Sohn H (2020) Effects of aluminum on the integrity of the intestinal epithelium: an in vitro and in vivo study. Environ Health Perspect 128(1):017013. ; Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T (2009) Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs 27(3):214–222. https://doi.org/10.1007/s10637-008-9159-7. (PMID: 10.1007/s10637-008-9159-7) ; Khalid U, Pino-Chavez G, Nesargikar P, Jenkins RH, Bowen T, Fraser DJ, Chavez R (2016) Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. J Histol Histopathol 3(1):1. https://doi.org/10.7243/2055-091x-3-1. (PMID: 10.7243/2055-091x-3-1) ; Kolset SO, Reinholt FP, Jenssen T (2012) Diabetic nephropathy and extracellular matrix. J Histochem Cytochem 60(12):976–986. ; Kongtawelert P, Wudtiwai B, Shwe TH, Pothacharoen P, Phitak T (2020) Inhibitory effect of hesperidin on the expression of programmed death ligand (PD-L1) in breast Cancer. Molecules 25(2):252. ; Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54(5):356–361. ; Kumar S, Dhankhar N, Kar V, Shrivastava M, Shrivastava S (2011) Myocardial injury provoked by cyclophosphamide, protective aspect of hesperidin in rats. Int J Res Pharm Biomed Sci 2(3):1288–1296. ; Labrie M, St-Pierre Y (2013) Epigenetic regulation of mmp-9 gene expression. Cell Mol Life Sci 70(17):3109–3124. ; Lee KA, Lee SH, Lee YJ, Baeg SM, Shim JH (2012) Hesperidin induces apoptosis by inhibiting Sp1 and its regulatory protein in MSTO-211H cells. Biomol Ther 20(3):273. ; Lee HJ, Im A-R, Kim S-M, Kang H-S, Lee JD, Chae S (2018) The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways. BMC Complement Altern Med 18(1):1–9. ; Lelongt B, Bengatta S, Delauche M, Lund LR, Werb Z, Ronco PM (2001) Matrix metalloproteinase 9 protects mice from anti–glomerular basement membrane nephritis through its fibrinolytic activity. J Exp Med 193(7):793–802. ; Li S, Zhang Q, Ding Y, Wang X, Liu P (2020) Flavonoids ameliorate aluminum chloride-induced learning and memory impairments via suppression of apoptosis and oxidative stress in rats. J Inorg Biochem 212:111252. ; Ling L, Chen L, Zhang C, Gui S, Zhao H, Li Z (2018) High glucose induces podocyte epithelial-to-mesenchymal transition by demethylation-mediated enhancement of MMP9 expression. Mol Med Rep 17(4):5642–5651. ; Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275. ; Mahieu S, Millen N, González M, del Carmen CM, Elías MM (2005) Alterations of the renal function and oxidative stress in renal tissue from rats chronically treated with aluminium during the initial phase of hepatic regeneration. J Inorg Biochem 99(9):1858–1864. ; Meng X, Wei M, Wang D, Qu X, Zhang K, Zhang N, Li X (2020) The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-κB/iNOS pathway in rats. Physiology International 107(1):82–91. ; Mishra K (2013) Structure-activity relationship of antioxidative property of hesperidin International Journal of Pharmaceutical Erudition Www.Pharmaerudition.Org, 2013; 2(4), 40–53. www.pharmaerudition.org. ; Mostafa H, Alaa-Eldin EA, Abouhashem NS, El-Shafei DA (2015) Toxic potentials of aluminum exposure on the brain, liver and kidney in adult male albino rats: biochemical, histopathological and immunohistochemical study. Mansoura J Forensic Med Clin Toxicol 23(2):45–67. ; Muhammad T, Ikram M, Ullah R, Rehman SU, Kim MO (2019) Hesperedin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling. Nutrients 11(3):648. ; Newby AC (2006) Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates. Cardiovasc Res 69(3):614–624. ; Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358. ; Okail HA, Ibrahim AS, Badr AH (2020) The protective effect of propolis against aluminum chloride-induced hepatorenal toxicity in albino rats. J Basic Appl Zool 81(1) https://doi.org/10.1186/s41936-020-00169-9. ; Pandey P, Sayyed U, Tiwari RK, Siddiqui MH, Pathak N, Bajpai P (2019) Hesperidin induces ROS-mediated apoptosis along with cell cycle arrest at G2/M phase in human gall bladder carcinoma. Nutr Cancer 71(4):676–87. ; Parasuraman S, Zhen KM, Raveendran R (2015) Retro-orbital sample collection in Rats-a video article. Pharmacology, Toxicology and Biomedical Reports 1(2):37–40. ; Pari L, Karthikeyan A, Karthika P, Rathinam A (2015) Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicol Rep 2:46–55. https://doi.org/10.1016/j.toxrep.2014.11.003. (PMID: 10.1016/j.toxrep.2014.11.003) ; Park HJ, Kim MJ, Ha E, Chung JH (2008) Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. Phytomedicine 15(1–2):147–51. ; Park WS, Park MS, Kang SW, Jin SA, Jeon Y, Hwang J, Kim SK (2019) Hesperidin shows protective effects on renal function in ischemia-induced acute kidney injury (Sprague-Dawley rats). In: Transplantation Proceedings,(Vol. 51, No. 8, pp. 2838-2841), Elsevier. ; Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J Cereb Blood Flow Metab 40(9):1769–77. ; Pérez-Vargas JE, Zarco N, Shibayama M, Segovia J, Tsutsumi V, Muriel P (2014) Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-κB, transforming growth factor-ß and connective tissue growth factor. Pharmacology 94(1–2):80–89. ; Pradeep K, Park SH, Ko KC (2008) Hesperidin a flavanoglycone protects against γ-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur J Pharmacol 587(1–3):273–280. https://doi.org/10.1016/j.ejphar.03.052. (PMID: 10.1016/j.ejphar.03.052) ; Pradère J-P, Gonzalez J, Klein J, Valet P, Grès S, Salant D, Bascands J-L, Saulnier-Blache J-S, Schanstra JP (2008) Lysophosphatidic acid and renal fibrosis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1781(9):582–587. ; Rushdy H, Salem A, Abd A, Mohamed E-R, Saleh EM, Shalaby KAF, Hiam, Salem RA (2012) Influence of hesperidin combined with Sinemet on genetical and biochemical abnormalities in rats suffering from Parkinson’s disease. In Life Science Journal 9(4). http://www.lifesciencesite.comhttp://www.lifesciencesite.com.145. ; Sahu BD, Kuncha M, Sindhura GJ, Sistla R (2013) Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage. Phytomedicine 20(5):453–460. ; Sargazi M, Shenkin A, Roberts NB (2006) Aluminium-induced injury to kidney proximal tubular cells: Effects on markers of oxidative damage. J Trace Elem Med Biol 19(4):267–273. ; Suvarna KS, Layton C, Bancroft JD, editors (2018) Bancroft's theory and practice of histological techniques EBook. Elsevier health sciences. . ; Tan TK, Zheng G, Hsu T-T, Lee SR, Zhang J, Zhao Y, Tian X, Wang Y, Wang YM, Cao Q (2013) Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Lab Invest 93(4):434–449. ; Tardif SD, Coleman K, Hobbs TR, Lutz C (2013) IACUC review of nonhuman primate research. ILAR J 54(2):234–45. ; Tribble DL, Aw TY, Jones DP (1987) The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 7(2):377–86. ; Tsai J-P, Liou J-H, Kao W-T, Wang S-C, Lian J-D, Chang H-R (2012) Increased expression of intranuclear matrix metalloproteinase 9 in atrophic renal tubules is associated with renal fibrosis. PLoS One 7(10):e48164. ; Tsioufis C, Bafakis I, Kasiakogias A, Stefanadis C (2012) The role of matrix metalloproteinases in diabetes mellitus. Curr Top Med Chem 12(10):1159–1165. ; Wang X, Zhou Y, Tan R, Xiong M, He W, Fang L, Wen P, Jiang L, Yang J (2010) Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy. Am J Physiol 299:F973–F982. ; Wilmsen PK, Spada DS, Salvador M (2005) Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 53(12):4757–4761. ; Wozniak J, Floege J, Ostendorf T, Ludwig A (2021) Key metalloproteinase-mediated pathways in the kidney. Nat Rev Nephrol 17(8):513–27. ; Xia R, Sheng X, Xu X, Yu C, Lu H (2018) Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells. Int J Mol Med 41(1):464–72. ; Xu F, Ren L, Song M, Shao B, Han Y, Cao Z, Li Y (2018) Fas-and mitochondria-mediated signaling pathway involved in osteoblast apoptosis induced by AlCl 3. Biol Trace Elem Res 184(1):173–185. ; Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y (2002a) Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Investig 110(10):1525–1538. ; Yang B, Johnson TS, Thomas GL, Watson PF, Wagner B, Furness PN, El Nahas AM (2002) A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Kidney Int 62(4):1301–13. ; Zahedi-Amiri Z, Taravati A, Hejazian LB (2019) Protective effect of Rosa damascena against aluminum chloride-induced oxidative stress. Biol Trace Elem Res 187(1):120–127. https://doi.org/10.1007/s12011-018-1348-4. (PMID: 10.1007/s12011-018-1348-4) ; Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Gesing A (2015) Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. Aging (albany NY) 7(3):195. ; Zhao H, Dong Y, Tian X, Tan TK, Liu Z, Zhao Y, Zhang Y, Harris DCH, Zheng G (2013) Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World J Nephrol 2(3):84.
  • Contributed Indexing: Keywords: ALCL3; EGTI scoring system; FAS; Hesperidin; Kidney; MMP-9
  • Substance Nomenclature: CPD4NFA903 (Aluminum) ; 3CYT62D3GA (Aluminum Chloride) ; E750O06Y6O (Hesperidin) ; EC 3.4.24.35 (Matrix Metalloproteinase 9)
  • Entry Date(s): Date Created: 20221222 Date Completed: 20230608 Latest Revision: 20240228
  • Update Code: 20240228
  • PubMed Central ID: PMC10039835

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

oder
oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

oder
oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

xs 0 - 576
sm 576 - 768
md 768 - 992
lg 992 - 1200
xl 1200 - 1366
xxl 1366 -