Einzeltreffer — DigiBib

A collective cell motility event that occurs during Drosophila eye development, ommatidial rotation (OR), serves as a paradigm for signaling-pathway-regulated directed movement of cell clusters. OR is instructed by the EGFR and Notch pathways and Frizzled/planar cell polarity (Fz/PCP) signaling, all of which are associated with photoreceptor R3 and R4 specification. Here, we show that Abl kinase negatively regulates OR through its activity in the R3/R4 pair. Abl is localized to apical junctional regions in R4, but not in R3, during OR, and this apical localization requires Notch signaling. We demonstrate that Abl and Notch interact genetically during OR, and Abl co-immunoprecipitates in complexes with Notch in eye discs. Perturbations of Abl interfere with adherens junctional organization of ommatidial preclusters, which mediate the OR process. Together, our data suggest that Abl kinase acts directly downstream of Notch in R4 to fine-tune OR via its effect on adherens junctions.

Competing Interests: Declaration of interests The authors declare no competing interests.

Titel:	Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila.
Autor/in / Beteiligte Person:	Koca, Y ; Vuong, LT ; Singh, J ; Giniger, E ; Mlodzik, M
Link:	Zum Volltext
Zeitschrift:	Cell reports, Jg. 41 (2022-12-06), Heft 10, S. 111788
Veröffentlichung:	[Cambridge, MA] : Cell Press, c 2012-, 2022
Medientyp:	academicJournal
ISSN:	2211-1247 (electronic)
DOI:	10.1016/j.celrep.2022.111788
Schlagwort:	Animals Cell Movement Drosophila
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [Cell Rep] 2022 Dec 06; Vol. 41 (10), pp. 111788. MeSH Terms: Drosophila* ; Animals ; Cell Movement References: Curr Top Dev Biol. 2010;93:189-227. (PMID: 20959167) ; Trends Cell Biol. 2004 Jan;14(1):36-44. (PMID: 14729179) ; Genes Dev. 1990 Nov;4(11):1848-61. (PMID: 2125959) ; Development. 1995 Sep;121(9):3045-55. (PMID: 7555730) ; Dev Cell. 2002 May;2(5):655-66. (PMID: 12015972) ; J Cell Biol. 2001 Dec 24;155(7):1185-98. (PMID: 11756472) ; Development. 1999 Dec;126(24):5725-38. (PMID: 10572048) ; J Cell Sci. 2009 Oct 1;122(Pt 19):3441-54. (PMID: 19759284) ; Dev Dyn. 2011 Feb;240(2):324-32. (PMID: 21246649) ; Cell. 2014 May 22;157(5):1146-59. (PMID: 24855950) ; Nat Cell Biol. 2005 Jul;7(7):691-7. (PMID: 15937478) ; Elife. 2017 Jan 13;6:. (PMID: 28085667) ; Curr Top Dev Biol. 2022;150:255-297. (PMID: 35817505) ; Dev Cell. 2012 Feb 14;22(2):309-19. (PMID: 22340496) ; Genes Dev. 2010 Oct 1;24(19):2157-68. (PMID: 20837657) ; EMBO J. 1999 Dec 15;18(24):6873-9. (PMID: 10601009) ; Dev Dyn. 2000 May;218(1):80-93. (PMID: 10822261) ; Cell Rep. 2021 Jan 12;34(2):108603. (PMID: 33440163) ; Cell. 1999 Sep 3;98(5):585-95. (PMID: 10490098) ; Int J Dev Biol. 2009;53(5-6):795-804. (PMID: 19557685) ; Nature. 1999 Feb 11;397(6719):526-30. (PMID: 10028969) ; Development. 2000 Aug;127(16):3619-29. (PMID: 10903185) ; Nature. 1999 Feb 11;397(6719):523-6. (PMID: 10028968) ; Development. 2003 Dec;130(24):5989-99. (PMID: 14597571) ; Cell. 2003 Mar 21;112(6):845-57. (PMID: 12654250) ; Neuron. 1998 Apr;20(4):667-81. (PMID: 9581760) ; Development. 2011 May;138(10):1877-92. (PMID: 21521735) ; Dev Cell. 2002 Dec;3(6):839-50. (PMID: 12479809) ; Development. 2010 Nov;137(21):3719-27. (PMID: 20940230) ; J Cell Biol. 2007 Apr 9;177(1):139-50. (PMID: 17420294) ; Open Biol. 2019 Aug 30;9(8):190148. (PMID: 31409231) ; Dev Biol. 2007 Oct 15;310(2):348-62. (PMID: 17826761) ; Development. 2017 Jan 15;144(2):187-200. (PMID: 28096212) ; Cell. 1994 Jul 15;78(1):125-36. (PMID: 8033204) ; Dev Biol. 1987 Apr;120(2):366-76. (PMID: 17985475) ; Dev Biol. 1989 Dec;136(2):346-62. (PMID: 2511048) ; Curr Opin Genet Dev. 1999 Aug;9(4):442-6. (PMID: 10449350) ; Development. 2003 Nov;130(22):5413-23. (PMID: 14507782) ; Development. 2017 Feb 1;144(3):487-498. (PMID: 28087633) ; Semin Cell Dev Biol. 2016 Jul;55:99-110. (PMID: 26994528) ; Development. 2007 Feb;134(3):567-78. (PMID: 17202187) ; Dev Biol. 2008 Apr 1;316(1):110-23. (PMID: 18291359) ; Cell. 1991 Nov 15;67(4):687-99. (PMID: 1657403) ; Science. 1990 Dec 7;250(4986):1370-7. (PMID: 2175046) ; Mol Cell Biol. 2014 Apr;34(7):1188-97. (PMID: 24421390) ; Neuron. 1998 Dec;21(6):1259-72. (PMID: 9883720) ; J Vis Exp. 2011 Aug 27;(54):. (PMID: 21897355) ; Nature. 2017 Dec 14;552(7684):258-262. (PMID: 29160307) ; Curr Biol. 1999 May 20;9(10):R356-60. (PMID: 10339422) ; Nat Cell Biol. 2001 Oct;3(10):883-90. (PMID: 11584269) ; Sci Rep. 2019 Dec 9;9(1):18628. (PMID: 31819141) ; Curr Top Dev Biol. 2012;101:1-31. (PMID: 23140623) ; Cell. 2003 Mar 21;112(6):859-71. (PMID: 12654251) ; Cell. 1998 Jul 10;94(1):109-18. (PMID: 9674432) ; J Cell Biol. 2003 Dec 22;163(6):1267-79. (PMID: 14676307) ; Dev Biol. 1999 Dec 1;216(1):406-22. (PMID: 10588889) ; Dev Biol. 2008 Jan 15;313(2):533-44. (PMID: 18068152) ; Nat Rev Mol Cell Biol. 2017 Jun;18(6):375-388. (PMID: 28293032) ; Anal Biochem. 1993 Apr;210(1):179-87. (PMID: 8489015) ; Development. 1998 Mar;125(6):1149-59. (PMID: 9463361) ; Development. 2006 Sep;133(17):3283-93. (PMID: 16887833) ; Nat Commun. 2018 Apr 9;9(1):1345. (PMID: 29632339) ; Dev Dyn. 2011 Jul;240(7):1745-55. (PMID: 21674685) ; PLoS Biol. 2004 Jul;2(7):E158. (PMID: 15252441) ; Trends Cell Biol. 2009 Jul;19(7):295-305. (PMID: 19560358) ; Development. 1991 Nov;113(3):841-50. (PMID: 1726564) ; Curr Top Dev Biol. 2012;101:33-53. (PMID: 23140624) ; Appl Microbiol Biotechnol. 2010 Sep;88(1):187-97. (PMID: 20535468) ; Dev Biol. 2008 Jan 15;313(2):556-67. (PMID: 18062953) ; Nat Struct Mol Biol. 2011 Jun;18(6):665-72. (PMID: 21552260) ; EMBO J. 2003 Sep 1;22(17):4409-20. (PMID: 12941693) ; Development. 2003 Nov;130(22):5401-12. (PMID: 14507785) ; Curr Opin Cell Biol. 2018 Apr;51:110-116. (PMID: 29289896) ; Cell. 2001 Apr 6;105(1):81-91. (PMID: 11301004) ; Nat Commun. 2021 Nov 30;12(1):6974. (PMID: 34848713) ; Mol Biol Cell. 2016 Sep 15;27(18):2822-32. (PMID: 27440923) Grant Information: P30 CA196521 United States CA NCI NIH HHS; R01 EY013256 United States EY NEI NIH HHS; R35 GM127103 United States GM NIGMS NIH HHS Contributed Indexing: Keywords: Abl; CP: Developmental biology; Drosophila; Notch; epithelial cell motility; junctional dynamics Entry Date(s): Date Created: 20221208 Date Completed: 20221215 Latest Revision: 20240607 Update Code: 20240607 PubMed Central ID: PMC9887719

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Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila.