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Introduction: Our primary objective was to determine if receiving intraoperative blood transfusion was a significant prognostic factor for overall and recurrence-free survival after curative resection of hepatic cellular carcinoma (HCC).

Methodology: Between 2001 and 2018, 1092 patients with histologically proven primary HCC who underwent curative liver resection were retrospectively reviewed. Primary study endpoints were recurrence-free survival (RFS) and overall survival (OS). The main analysis was undertaken using propensity-score matching (PSM) to minimize confounding and selection biases in the comparison of patients with or without transfusion.

Results: There were 220 patients who received and 666 patients who did not receive intraoperative blood transfusion. The PSM cohort consisted of 163 pairs of patients. After PSM, the only perioperative outcome that appeared to significantly affect whether patients would receive blood transfusion was median blood loss (p = 0.001). In the PSM cohort, whether patients received blood transfusion was neither associated with OS (p = 0.759) nor RFS (p = 0.830). When the volume of blood transfusion was analyzed as a continuous variable, no significant dose-response relationship between blood transfusion volume and HR for OS and RFS was noted.

Conclusion: Intraoperative blood transfusion had no significant impact on the survival outcomes in patients who receive curative resection in primary HCC.

Titel:	Intraoperative blood transfusion does not impact overall and recurrence-free survival after curative hepatectomy for hepatocellular carcinoma: A propensity-score-matched and inverse probability of treatment-weighted study.
Autor/in / Beteiligte Person:	Tan, LLY ; Chew, VTW ; Syn, N ; Tan, EK ; Koh, YX ; Teo, JY ; Cheow, PC ; Jeyaraj, PR ; Chow, PKH ; Chan, CY ; Chung, AYF ; Ooi, LLPJ ; Goh, BKP
Link:	Zum Volltext
Zeitschrift:	Journal of surgical oncology, Jg. 127 (2023-03-01), Heft 4, S. 598-606
Veröffentlichung:	<2005-> : Hoboken, NJ : Wiley-Liss ; <i>Original Publication</i>: New York, Plenum., 2023
Medientyp:	academicJournal
ISSN:	1096-9098 (electronic)
DOI:	10.1002/jso.27141
Schlagwort:	Humans Hepatectomy Retrospective Studies Blood Transfusion Propensity Score Neoplasm Recurrence, Local pathology Prognosis Carcinoma, Hepatocellular pathology Liver Neoplasms pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Surg Oncol] 2023 Mar; Vol. 127 (4), pp. 598-606. <i>Date of Electronic Publication: </i>2022 Nov 10. MeSH Terms: Carcinoma, Hepatocellular* / pathology ; Liver Neoplasms* / pathology ; Humans ; Hepatectomy ; Retrospective Studies ; Blood Transfusion ; Propensity Score ; Neoplasm Recurrence, Local / pathology ; Prognosis References: Koh YX, Tan HL, Lye WK, et al. Systematic review of the outcomes of surgical resection for intermediate and advanced barcelona clinic liver cancer stage hepatocellular carcinoma: a critical appraisal of the evidence. World J Hepatol. 2018;10(6):433-447. ; Choo SP, Tan WL, Goh BKP, Tai WM, Zhu AX. Comparison of hepatocellular carcinoma in eastern versus Western populations. Cancer. 2016;122(22):3430-3446. ; Goh B, Teo J, Chan C, et al. 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No impact of perioperative blood transfusion on recurrence of hepatocellular carcinoma after hepatectomy. World J Surg. 2012;36(3):651-658. ; Yang T, Lu JH, Lau WY, et al. Perioperative blood transfusion does not influence recurrence-free and overall survivals after curative resection for hepatocellular carcinoma. J Hepatol. 2016;64(3):583-593. ; Yamashita Y, Hayashi H, Imai K, et al. Perioperative allogeneic blood transfusion does not influence patient survival after hepatectomy for hepatocellular carcinoma: a propensity score matching analysis. World J Surg. 2019;43(11):2894-2901. ; Chen GX, Qi CY, Hu WJ, et al. Perioperative blood transfusion has distinct postsurgical oncologic impact on patients with different stage of hepatocellular carcinoma. BMC Cancer. 2020;20(1):487. ; Ejaz A, Spolverato G, Kim Y, et al. Impact of blood transfusions and transfusion practices on long-term outcome following hepatopancreaticobiliary surgery. 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Propensity score matching and inverse probability of treatment weighting to address confounding by indication in comparative effectiveness research of oral anticoagulants. J Comp Eff Res. 2020;9(9):603-614. Contributed Indexing: Keywords: blood transfusion; hepatectomy; hepatocellular carcinoma; prognosis; resection; survival Entry Date(s): Date Created: 20221110 Date Completed: 20230213 Latest Revision: 20230213 Update Code: 20240513

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Intraoperative blood transfusion does not impact overall and recurrence-free survival after curative hepatectomy for hepatocellular carcinoma: A propensity-score-matched and inverse probability of treatment-weighted study.