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UVA1 therapy is effective in the treatment of inflammatory and autoimmune skin diseases. The mode of action of UVA1 therapy is not completely understood and especially data on cells of the innate immune system like monocytes, which are critically involved in many inflammatory processes, are sparse. We wanted to answer the question whether UVA1 irradiation alters functional properties of human monocytes. We treated human peripheral blood monocytes in vitro with 2 J/cm 2 UVA1 light, incubated the cells for 48 h and examined both functional properties and alterations in the gene and protein expression profile. While UVA1 did not alter cell viability or susceptibility to apoptosis inducing agents, it decreased the capacity of monocytes for phagocytosis and to eliminate infectious agents like Leishmania major. Moreover, we measured a significantly reduced production of interleukin (IL)-1β mRNA in lipopolysaccharide activated monocytes after UVA1 treatment. Importantly, UVA1-treated monocytes not only produce less IL-1β, but also upregulate expression of the anti-inflammatory IL-1β decoy receptor. Our data provide evidence that UVA1 radiation not only interferes with fundamental monocyte properties like phagocytosis, pathogen killing and activation, but could also specifically attenuate pro-inflammatory IL-1 effects. This might constitute a hitherto unknown anti-inflammatory mechanism of UVA1 in human monocytes.

Titel:	UVA1 radiation attenuates pro-inflammatory functions in human monocytes.
Autor/in / Beteiligte Person:	Peters, AF ; Kusche, Y ; Gerdkamp, H ; Nattkemper, E ; Vischedyk, K ; Münck, NA ; Weishaupt, C ; Roth, J ; Barczyk-Kahlert, K ; Sunderkötter, C ; Ehrchen, JM
Link:	Zum Volltext
Zeitschrift:	The Journal of dermatology, Jg. 50 (2023), Heft 1, S. 46-56
Veröffentlichung:	London : Wiley-Blackwell ; <i>Original Publication</i>: Tokyo, Japanese Dermatological Association, <-2005>, 2023
Medientyp:	academicJournal
ISSN:	1346-8138 (electronic)
DOI:	10.1111/1346-8138.16600
Schlagwort:	Humans Monocytes
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UVA1 radiation attenuates pro-inflammatory functions in human monocytes.