| Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article; Research Support, Non-U.S. Gov't
- Language: English
- [Pain] 2023 Mar 01; Vol. 164 (3), pp. 463-468. <i>Date of Electronic Publication: </i>2022 Jun 17.
- MeSH Terms: Diffuse Noxious Inhibitory Control* ; Humans ; Neurobiology ; Pain
- References: Akil H, Mayer DJ, Liebeskind JC. Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science 1976;191:961–2. ; Antal M, Petkó M, Polgár E, Heizmann CW, Storm-Mathisen J. Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla. Neuroscience 1996;73:509–18. ; Arendt-Nielsen L, Andresen T, Malver LP, Oksche A, Mansikka H, Drewes AM. A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 2012;28:623–27. ; Baba Y, Kohase H, Oono Y, Fujii-Abe K, Arendt-Nielsen L. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 2012;16:1137–47. ; Bagley EE, Ingram SL. Endogenous opioid peptides in the descending pain modulatory circuit. Neuropharmacology 2020;173:108131. ; Bannister K, Dickenson AH. The plasticity of descending controls in pain: translational probing. J Physiol 2017;595:4159–66. ; Bannister K, Kucharczyk MW, Graven-Nielsen T, Porreca F. Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals. PAIN 2021;162:1957–9. ; Bannister K, Patel R, Goncalves L, Townson L, Dickenson AH. Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations. PAIN 2015;156:1803–11. ; Bardoni R. Serotonergic modulation of nociceptive circuits in spinal cord dorsal horn. Curr Neuropharmacol 2019;17:1133–45. ; Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984;7:309–38. ; Bosma RL, Stroman PW. Assessment of data acquisition parameters, and analysis techniques for noise reduction in spinal cord fMRI data. Magn Reson Imaging 2014;32:473–81. ; Bouhassira D, Le Bars D, Bolgert F, Laplane D, Willer JC. Diffuse noxious inhibitory controls in humans: a neurophysiological investigation of a patient with a form of Brown-Séquard syndrome. Ann Neurol 1993;34:536–43. ; Bouhassira D, Villanueva L, Bing Z, le Bars D. Involvement of the subnucleus reticularis dorsalis in diffuse noxious inhibitory controls in the rat. Brain Res 1992;595:353–7. ; Bruehl S, Chung OY. Interactions between the cardiovascular and pain regulatory systems: an updated review of mechanisms and possible alterations in chronic pain. Neurosci Biobehav Rev 2004;28:395–414. ; Bruehl S, France CR, Stone AL, Gupta R, Buvanendran A, Chont M, Burns JW. Greater conditioned pain modulation is associated with enhanced morphine analgesia in healthy individuals and patients with chronic low back pain. Clin J Pain 2021;37:20–7. ; Cai YQ, Wang W, Hou YY, Pan ZZ. Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization. Mol Pain 2014;10:70. ; Callado LF, Stamford JA. Alpha2A- but not alpha2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur J Pharmacol 1999;366:35–9. ; Callaway EM, Luo L. Monosynaptic circuit tracing with glycoprotein-deleted rabies viruses. J Neurosci 2015;35:8979–85. ; Cannon JT, Prieto GJ, Lee A, Liebeskind JC. Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat. Brain Res 1982;243:315–21. ; Cesselin F, Le Bars D, Bourgoin S, Artaud F, Gozlan H, Clot AM, Besson JM, Hamon M. Spontaneous and evoked release of methionine-enkephalin-like material from the rat spinal cord in vivo. Brain Res 1985;339:305–13. ; Chalaye P, Devoize L, Lafrenaye S, Dallel R, Marchand S. Cardiovascular influences on conditioned pain modulation. PAIN 2013;154:1377–82. ; Chen Q, Heinricher MM. Descending control mechanisms and chronic pain. Curr Rheumatol Rep 2019;21:13. ; Chitour D, Dickenson AH, Le Bars D. Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Res 1982;236:329–37. ; Corder G, Castro DC, Bruchas MR, Scherrer G. Endogenous and exogenous opioids in pain. Annu Rev Neurosci 2018;41:453–73. ; Cummins TM, Kucharczyk MM, Graven-Nielsen T, Bannister K. Activation of the descending pain modulatory system using cuff pressure algometry: back translation from man to rat. Eur J Pain 2020;24:1330–8. ; Cummins TM, McMahon SB, Bannister K. The impact of paradigm and stringent analysis parameters on measuring a net conditioned pain modulation effect: a test, retest, control study. Eur J Pain 2021;25:415–29. ; Dayan L, Hochberg U, Nahman-Averbuch H, Brill S, Ablin JN, Jacob G. Increased sympathetic outflow induces adaptation to acute experimental pain. Pain Pract 2018;18:322–30. ; De Broucker T, Cesaro P, Willer JC, Le Bars D. Diffuse noxious inhibitory controls in man. Involvement of the spinoreticular tract. Brain 1990;113:1223–34. ; Dickenson AH, Le Bars D. Diffuse noxious inhibitory controls (DNIC) involve trigeminothalamic and spinothalamic neurones in the rat. Exp Brain Res 1983;49:174–80. ; Dickenson AH, Rivot JP, Chaouch A, Besson JM, Le Bars D. Diffuse noxious inhibitory controls (DNIC) in the rat with or without pCPA pretreatment. Brain Res 1981;216:313–21. ; Drower EJ, Hammond DL. GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain Res 1988;450:316–24. ; Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology 1990;73:273–7. ; Edwards RR, Ness TJ, Fillingim RB. Endogenous opioids, blood pressure, and diffuse noxious inhibitory controls: a preliminary study. Percept Mot Skills 2004;99:679–87. ; Firouzian S, Osborne NR, Cheng JC, Kim JA, Bosma RL, Hemington KS, Rogachov A, Davis KD. Individual variability and sex differences in conditioned pain modulation and the impact of resilience, and conditioning stimulus pain unpleasantness and salience. PAIN 2020;161:1847–60. ; Foster E, Wildner H, Tudeau L, Haueter S, Ralvenius WT, Jegen M, Johannssen H, Hösli L, Haenraets K, Ghanem A, Conzelmann KK, Bösl M, Zeilhofer HU. Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch. Neuron 2015;85:1289–304. ; France CR, Burns JW, Gupta RK, Buvanendran A, Chont M, Schuster E, Orlowska D, Bruehl S. Expectancy effects on conditioned pain modulation are not influenced by naloxone or morphine. Ann Behav Med 2016;50:497–505. ; François A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Sharif-Naeini R, Deisseroth K, Delp SL, Malenka RC, Luo L, Hantman AW, Scherrer G. A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron 2017;93:822–39. e6. ; Ghanem A, Conzelmann KK. G gene-deficient single-round rabies viruses for neuronal circuit analysis. Virus Res 2016;216:41–54. ; Graeff P, Itter A, Wach K, Ruscheweyh R. Inter-individual differences explain more variance in conditioned pain modulation than age, sex and conditioning stimulus intensity combined. Brain Sci 2021;11:1186. ; Graven-Nielsen T, Gibson SJ, Laursen RJ, Svensson P, Arendt-Nielsen L. Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers. Exp Brain Res 2002;146:213–22. ; Guenthner CJ, Miyamichi K, Yang HH, Heller HC, Luo L. Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron 2013;78:773–84. ; Guindon J, Hohmann AG. The endocannabinoid system and pain. CNS Neurol Disord Drug Targets 2009;8:403–21. ; Häring M, Zeisel A, Hochgerner H, Rinwa P, Jakobsson JET, Lönnerberg P, La Manno G, Sharma N, Borgius L, Kiehn O, Lagerström MC, Linnarsson S, Ernfors P. Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types. Nat Neurosci 2018;21:869–80. ; Hermans L, Nijs J, Calders P, De Clerck L, Moorkens G, Hans G, Grosemans S, Roman De Mettelinge T, Tuynman J, Meeus M. Influence of morphine and naloxone on pain modulation in rheumatoid arthritis, chronic fatigue syndrome/fibromyalgia, and controls: a double-blind, randomized, placebo-controlled, cross-over study. Pain Pract 2018;18:418–30. ; Hickey L, Li Y, Fyson SJ, Watson TC, Perrins R, Hewinson J, Teschemacher AG, Furue H, Lumb BM, Pickering AE. Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats. J Neurosci 2014;34:4148–60. ; Hines EA. A standard stimulus for measuring vasomotor reactions: its application in the study of hypertension. Mayo Clin Proc 1932;7:332–35. ; Hirschberg S, Li Y, Randall A, Kremer EJ, Pickering AE. Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 2017;6:e29808. ; Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. An endocannabinoid mechanism for stress-induced analgesia. Nature 2005;435:1108–12. ; Imai Y, Petersen KK, Mørch CD, Arendt Nielsen L. Comparing test-retest reliability and magnitude of conditioned pain modulation using different combinations of test and conditioning stimuli. Somatosens Mot Res 2016;33:169–77. ; Kennedy DL, Kemp HI, Ridout D, Yarnitsky D, Rice AS. Reliability of conditioned pain modulation: a systematic review. PAIN 2016;157:2410–19. ; Kiemes A, Davies C, Kempton MJ, Lukow PB, Bennallick C, Stone JM, Modinos G. GABA, glutamate and neural activity: a systematic review with meta-analysis of multimodal (1)H-MRS-fMRI studies. Front Psychiatry 2021;12:644315. ; King CD, Goodin B, Kindler LL, Caudle RM, Edwards RR, Gravenstein N, Riley JL III, Fillingim RB. Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing. J Behav Med 2013;36:315–27. ; Klinger-Gratz PP, Ralvenius WT, Neumann E, Kato A, Nyilas R, Lele Z, Katona I, Zeilhofer HU. Acetaminophen relieves inflammatory pain through CB1 cannabinoid receptors in the rostral ventromedial medulla. J Neurosci 2018;38:322–34. ; Kucharczyk MW, Valiente D, Bannister K. Developments in understanding diffuse noxious inhibitory controls: pharmacological evidence from pre-clinical research. J Pain Res 2021;14:1083–95. ; Kunz M, Scholl KE, Schu U, Lautenbacher S. GABAergic modulation of diffuse noxious inhibitory controls (DNIC): a test by use of lorazepam. Exp Brain Res 2006;175:363–71. ; Lau BK, Vaughan CW. Descending modulation of pain: the GABA disinhibition hypothesis of analgesia. Curr Opin Neurobiol 2014;29:159–64. ; Le Bars D. The whole body receptive field of dorsal horn multireceptive neurones. Brain Res Brain Res Rev 2002;40:29–44. ; Le Bars D, Chitour D, Kraus E, Clot AM, Dickenson AH, Besson JM. The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurones. Brain Res 1981;215:257–74. ; Le Bars D, Chitour D, Kraus E, Dickenson AH, Besson JM. Effect of naloxone upon diffuse noxious inhibitory controls (DNIC) in the rat. Brain Res 1981;204:387–402. ; Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. PAIN 1979;6:283–304. ; Le Bars D, Willer JC, De Broucker T. Morphine blocks descending pain inhibitory controls in humans. PAIN 1992;48:13–20. ; Lichtman AH, Cook SA, Martin BR. Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement. J Pharmacol Exp Ther 1996;276:585–93. ; Llorca-Torralba M, Borges G, Neto F, Mico JA, Berrocoso E. Noradrenergic Locus Coeruleus pathways in pain modulation. Neuroscience 2016;338:93–113. ; Martini C, van Velzen M, Drewes A, Aarts L, Dahan A, Niesters M. A randomized controlled trial on the effect of tapentadol and morphine on conditioned pain modulation in healthy volunteers. PLoS One 2015;10:e0128997. ; Moriya S, Yamashita A, Nishi R, Ikoma Y, Yamanaka A, Kuwaki T. Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice. IBRO Rep 2019;7:1–9. ; Mullins PG, Rowland LM, Jung RE, Sibbitt WL Jr. A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy. Neuroimage 2005;26:642–6. ; Nahman-Averbuch H, Dayan L, Sprecher E, Hochberg U, Brill S, Yarnitsky D, Jacob G. Pain modulation and autonomic function: the effect of clonidine. Pain Med 2016;17:1292–301. ; Nation KM, De Felice M, Hernandez PI, Dodick DW, Neugebauer V, Navratilova E, Porreca F. Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain. PAIN 2018;159:919–28. ; Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ. The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study. Br J Clin Pharmacol 2017;83:976–90. ; Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain. Curr Opin Support Palliat Care 2014;8:143–51. ; Palazzo E, Luongo L, Novellis V, Rossi F, Maione S. The role of cannabinoid receptors in the descending modulation of pain. Pharmaceuticals (Basel) 2010;3:2661–73. ; Pertovaara A, Kemppainen P, Johansson G, Karonen SL. Ischemic pain nonsegmentally produces a predominant reduction of pain and thermal sensitivity in man: a selective role for endogenous opioids. Brain Res 1982;251:83–92. ; Petersen KK, Andersen HH, Tsukamoto M, Tracy L, Koenig J, Arendt-Nielsen L. The effects of propranolol on heart rate variability and quantitative, mechanistic, pain profiling: a randomized placebo-controlled crossover study. Scand J Pain 2018;18:479–89. ; Phelps CE, Navratilova E, Dickenson AH, Porreca F, Bannister K. Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain. PAIN 2019;160:1614–21. ; Piché M, Watanabe N, Sakata M, Oda K, Toyohara J, Ishii K, Ishiwata K, Hotta H. Basal μ-opioid receptor availability in the amygdala predicts the inhibition of pain-related brain activity during heterotopic noxious counter-stimulation. Neurosci Res 2014;81–82:78–84. ; Pud D, Granovsky Y, Yarnitsky D. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans. PAIN 2009;144:16–9. ; Ravotto L, Duffet L, Zhou X, Weber B, Patriarchi T. A bright and colorful future for G-protein coupled receptor sensors. Front Cell Neurosci 2020;14:67. ; Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, Reisine T. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol 1994;45:330–4. ; Redmond WJ, Goffaux P, Potvin S, Marchand S. Analgesic and antihyperalgesic effects of nabilone on experimental heat pain. Curr Med Res Opin 2008;24:1017–24. ; Roby-Brami A, Bussel B, Willer JC, Le Bars D. An electrophysiological investigation into the pain-relieving effects of heterotopic nociceptive stimuli. Probable involvement of a supraspinal loop. Brain 1987;110:1497–508. ; Rodriguez E, Sakurai K, Xu J, Chen Y, Toda K, Zhao S, Han BX, Ryu D, Yin H, Liedtke W, Wang F. A craniofacial-specific monosynaptic circuit enables heightened affective pain. Nat Neurosci 2017;20:1734–43. ; Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology 2007;106:787–94. ; Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX, Wang F. Capturing and manipulating activated neuronal ensembles with CANE delineates a hypothalamic social-fear circuit. Neuron 2016;92:739–53. ; Sanada T, Kohase H, Makino K, Umino M. Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control. J Med Dent Sci 2009;56:17–24. ; Sprenger C, Bingel U, Büchel C. Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation. PAIN 2011;152:428–39. ; Suzan E, Midbari A, Treister R, Haddad M, Pud D, Eisenberg E. Oxycodone alters temporal summation but not conditioned pain modulation: preclinical findings and possible relations to mechanisms of opioid analgesia. PAIN 2013;154:1413–8. ; Swan HJ. Noradrenaline, adrenaline, and the human circulation. Br Med J 1952;1:1003–6. ; Tervo DG, Hwang BY, Viswanathan S, Gaj T, Lavzin M, Ritola KD, Lindo S, Michael S, Kuleshova E, Ojala D, Huang CC, Gerfen CR, Schiller J, Dudman JT, Hantman AW, Looger LL, Schaffer DV, Karpova AY. A designer AAV variant permits efficient retrograde access to projection neurons. Neuron 2016;92:372–82. ; Todd AJ. Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci 2010;11:823–36. ; van Amerongen G, Siebenga PS, Gurrell R, Dua P, Whitlock M, Gorman D, Okkerse P, Hay JL, Butt RP, Groeneveld GJ. Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA(A) partial agonist, in humans. Br J Anaesth 2019;123:e194–203. ; Villanueva L, Chitour D, Le Bars D. Involvement of the dorsolateral funiculus in the descending spinal projections responsible for diffuse noxious inhibitory controls in the rat. J Neurophysiol 1986;56:1185–95. ; Vuilleumier PH, Besson M, Desmeules J, Arendt-Nielsen L, Curatolo M. Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. PLoS One 2013;8:e43896. ; Wang F, Bélanger E, Paquet ME, Côté DC, De Koninck Y. Probing pain pathways with light. Neuroscience 2016;338:248–71. ; Wei F, Dubner R, Zou S, Ren K, Bai G, Wei D, Guo W. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. J Neurosci 2010;30:8624–36. ; Whissell PD, Tohyama S, Martin LJ. The use of DREADDs to deconstruct behavior. Front Genet 2016;7:70. ; Willer JC, Le Bars D, De Broucker T. Diffuse noxious inhibitory controls in man: involvement of an opioidergic link. Eur J Pharmacol 1990;182:347–55. ; Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav 1985;22:845–58. ; Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain 2010;14:339. ; Yarnitsky D, Bouhassira D, Drewes AM, Fillingim RB, Granot M, Hansson P, Landau R, Marchand S, Matre D, Nilsen KB, Stubhaug A, Treede RD, Wilder-Smith OH. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain 2015;19:805–6. ; Yesilyurt O, Seyrek M, Tasdemir S, Kahraman S, Deveci MS, Karakus E, Halici Z, Dogrul A. The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia. Eur J Pharmacol 2015;762:402–10. ; Zhang Y, Zhao S, Rodriguez E, Takatoh J, Han BX, Zhou X, Wang F. Identifying local and descending inputs for primary sensory neurons. J Clin Invest 2015;125:3782–94.
- Entry Date(s): Date Created: 20220826 Date Completed: 20230214 Latest Revision: 20230818
- Update Code: 20240513
- PubMed Central ID: PMC9916052
|
