Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study.
In: Scientific reports, Jg. 12 (2022-07-13), Heft 1, S. 11864
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Zugriff:
The aim of this single-center retrospective study was to investigate the association between the time in range (TIR) of relative normoglycemia (RN) and in-hospital mortality. We defined RN as measured blood glucose in the range of 70-140% of A1C-derived average glucose and absolute normoglycemia (AN) as 70-140 mg/dL. We conducted multivariate logistic regression analyses to examine the association between TIR of RN > 80% or TIR of AN > 80% up to 72 h after ICU admission and in-hospital mortality (Model 1 and Model 2, respectively). The discrimination of the models was assessed using the area under the receiver operating characteristic curve (AUROC). Among 328 patients, 35 died in hospital (11%). Model 1 showed that TIR of RN > 80% was associated with reduced in-hospital mortality (adjusted OR 0.16; 95% CI 0.06-0.43; P < 0. 001); however, Model 2 showed that the TIR of AN > 80% was not. The AUROC of Model 1 was significantly higher than that of Model 2 (0.84 [95% CI 0.77-0.90] vs. 0.79 [0.70-0.87], P = 0.008).Our findings provide a foundation for further studies exploring individualized glycemic management in ICUs.
(© 2022. The Author(s).)
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Association between time in range of relative normoglycemia and in-hospital mortality in critically ill patients: a single-center retrospective study.
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Autor/in / Beteiligte Person: | Okazaki, T ; Inoue, A ; Taira, T ; Nakagawa, S ; Kawakita, K ; Kuroda, Y |
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Zeitschrift: | Scientific reports, Jg. 12 (2022-07-13), Heft 1, S. 11864 |
Veröffentlichung: | London : Nature Publishing Group, copyright 2011-, 2022 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (electronic) |
DOI: | 10.1038/s41598-022-15795-2 |
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