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Epimedium brevicornum Maxim, a Traditional Chinese Medicine, has been used for the treatment of impotence, sinew and bone disorders, "painful impediment caused by wind-dampness," numbness, spasms, hypertension, coronary heart disease, menopausal syndrome, bronchitis, and neurasthenia for many years in China. Recent animal experimental studies indicate that icariin, a major bioactive component of epimedium may effectively treat Alzheimer's disease, cerebral ischemia, depression, Parkinson's disease, multiple sclerosis, as well as delay ageing. Our recent study also suggested that epimedium extract could exhibit radio-neuro-protective effects and prevent ionizing radiation-induced impairment of neurogenesis. This paper reviewed the pharmacodynamics of icariin in treating different neurodegenerative and neuropsychiatric diseases, ageing, and radiation-induced brain damage. The relevant molecular mechanisms and its anti-neuroinflammatory, anti-apoptotic, anti-oxidant, as well as pro-neurogenesis roles were also discussed.

Titel:	The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure.
Autor/in / Beteiligte Person:	Li, LR ; Sethi, G ; Zhang, X ; Liu, CL ; Huang, Y ; Liu, Q ; Ren, BX ; Tang, FR
Link:	Zum Volltext
Zeitschrift:	Aging, Jg. 14 (2022-02-14), Heft 3, S. 1562
Veröffentlichung:	Albany, NY : Impact Journals, LLC, 2022
Medientyp:	academicJournal
ISSN:	1945-4589 (electronic)
DOI:	10.18632/aging.203893
Schlagwort:	Aging Animals Flavonoids pharmacology Flavonoids therapeutic use Male Brain Injuries Epimedium Neuroprotective Agents pharmacology Neuroprotective Agents therapeutic use Radiation Exposure
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Aging (Albany NY)] 2022 Feb 14; Vol. 14 (3), pp. 1562-1588. <i>Date of Electronic Publication: </i>2022 Feb 14. MeSH Terms: Brain Injuries* ; Epimedium* ; Neuroprotective Agents* / pharmacology ; Neuroprotective Agents* / therapeutic use ; Radiation Exposure* ; Aging ; Animals ; Flavonoids / pharmacology ; Flavonoids / therapeutic use ; Male References: Neuropharmacology. 2010 Nov;59(6):542-50. (PMID: 20708632) ; PLoS One. 2014 Aug 07;9(8):e104616. (PMID: 25101849) ; Neuropharmacology. 2010 Jul-Aug;59(1-2):70-6. (PMID: 20381504) ; Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5919-24. (PMID: 19321751) ; Lancet. 2018 Nov 24;392(10161):2299-2312. (PMID: 30396512) ; Biomed Pharmacother. 2019 Sep;117:109077. (PMID: 31177064) ; Photochem Photobiol Sci. 2018 Oct 10;17(10):1396-1408. (PMID: 30225503) ; Int Immunopharmacol. 2016 Jan;30:157-162. (PMID: 26679678) ; Mol Med Rep. 2016 Aug;14(2):1316-22. (PMID: 27278906) ; Brain Res. 2011 Feb 23;1375:59-67. (PMID: 21182828) ; J Alzheimers Dis. 2018;62(3):1319-1335. (PMID: 29562533) ; Biochem J. 2008 Apr 15;411(2):e11-3. (PMID: 18363549) ; Front Neurosci. 2016 May 03;10:178. (PMID: 27199641) ; Eur J Neurol. 2019 Jan;26(1):27-40. (PMID: 30300457) ; Curr Med Chem. 2015;22(10):1258-77. (PMID: 25666795) ; J Affect Disord. 2018 Jun;233:45-67. (PMID: 29150144) ; Neuroreport. 2020 Jun 7;31(9):663-671. (PMID: 32427716) ; Brain Dev. 2017 Aug;39(7):593-600. (PMID: 28395974) ; Parkinsonism Relat Disord. 2017 Jan;34:1-6. (PMID: 28341222) ; Am J Pathol. 2008 Nov;173(5):1488-95. (PMID: 18818379) ; Br J Radiol. 2012 Dec;85(1020):e1166-73. (PMID: 23175483) ; Neurochem Res. 2019 Dec;44(12):2708-2722. (PMID: 31612304) ; Molecules. 2010 Nov 03;15(11):7861-70. (PMID: 21060294) ; Annu Rev Clin Psychol. 2018 May 7;14:1-28. (PMID: 29328780) ; Biomed Pharmacother. 2017 Aug;92:856-863. (PMID: 28599249) ; Biomed Pharmacother. 2018 Dec;108:663-669. (PMID: 30245466) ; Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11232-7. (PMID: 11016969) ; J Physiol. 2005 Aug 1;566(Pt 3):821-37. (PMID: 15919712) ; Zhonghua Nan Ke Xue. 2010 May;16(5):474-9. (PMID: 20684332) ; J Ethnopharmacol. 2013 Feb 13;145(3):715-21. (PMID: 23261485) ; Eur J Neurosci. 2005 Mar;21(6):1489-502. (PMID: 15845077) ; Basic Clin Pharmacol Toxicol. 2010 Nov;107(5):899-905. (PMID: 20533910) ; Eur J Pharmacol. 2019 Jan 5;842:20-32. (PMID: 30342950) ; Clin Exp Pharmacol Physiol. 2009 Aug;36(8):810-5. (PMID: 19215241) ; Aging Dis. 2017 Dec 1;8(6):868-886. (PMID: 29344421) ; Oral Oncol. 2019 Nov;98:35-47. (PMID: 31536844) ; Neuroscience. 2004;127(3):601-9. (PMID: 15283960) ; Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189. (PMID: 22229116) ; Cancer Sci. 2020 Nov;111(11):4242-4256. (PMID: 32926492) ; Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15998-6003. (PMID: 15520384) ; J Biol Chem. 2005 Apr 22;280(16):16456-60. (PMID: 15716268) ; PLoS One. 2015 Mar 25;10(3):e0119955. (PMID: 25806530) ; Phytother Res. 2010 Nov;24(11):1658-63. (PMID: 21031624) ; Eur J Neurol. 2018 Jan;25(1):59-70. (PMID: 28872215) ; Int J Mol Med. 2016 Jul;38(1):337-44. (PMID: 27221032) ; Molecules. 2016 Oct 13;21(10):. (PMID: 27754387) ; Stem Cells Int. 2021 Jun 23;2021:9974625. (PMID: 34257671) ; Adv Nutr. 2015 Jan 15;6(1):64-72. (PMID: 25593144) ; Int J Neuropsychopharmacol. 2014 Jun;17(6):871-81. (PMID: 24513083) ; J Pharmacol Exp Ther. 2019 Apr;369(1):121-128. (PMID: 30837279) ; Int Immunopharmacol. 2019 Oct;75:105799. (PMID: 31401387) ; Acta Neuropathol. 2013 Aug;126(2):237-49. (PMID: 23812288) ; Curr Med Chem. 2012;19(12):1864-9. (PMID: 22376039) ; Front Pharmacol. 2016 Oct 07;7:362. (PMID: 27774066) ; Int J Pharm. 2020 Aug 30;586:119550. (PMID: 32554031) ; Curr Opin Lipidol. 2009 Apr;20(2):98-105. (PMID: 19276888) ; Int J Biochem Cell Biol. 2009 Jun;41(6):1284-95. (PMID: 19038359) ; F1000Res. 2017 Mar 13;6:260. (PMID: 28357055) ; Am J Transl Res. 2016 Apr 15;8(4):1910-8. (PMID: 27186315) ; Biotechnol Appl Biochem. 2019 May;66(3):465-471. (PMID: 30892727) ; Front Neurosci. 2021 Jun 17;15:649485. (PMID: 34220419) ; Front Neurosci. 2012 Jun 04;6:81. (PMID: 22675290) ; Neuropsychiatr Dis Treat. 2021 Sep 23;17:2995-3006. (PMID: 34588779) ; J Exp Med. 2007 Jun 11;204(6):1273-80. (PMID: 17517969) ; J Neuroinflammation. 2019 Apr 22;16(1):92. (PMID: 31010422) ; Neuron. 2014 Mar 5;81(5):1214. (PMID: 28898628) ; Neurosci Lett. 2016 Apr 21;619:34-42. (PMID: 26879835) ; Nat Rev Neurol. 2015 Jan;11(1):56-64. (PMID: 25385337) ; Cancers (Basel). 2018 Dec 03;10(12):. (PMID: 30513925) ; Dev Cell. 2005 Nov;9(5):605-15. (PMID: 16256736) ; Mol Med Rep. 2012 Nov;6(5):967-72. (PMID: 22923091) ; Int J Neuropsychopharmacol. 2017 Jun 1;20(6):485-497. (PMID: 28339691) ; Int Immunopharmacol. 2011 Jul;11(7):890-8. (PMID: 21244860) ; Metab Brain Dis. 2017 Aug;32(4):1163-1172. (PMID: 28429187) ; PLoS One. 2018 Mar 22;13(3):e0194896. (PMID: 29566083) ; Life Sci. 2019 Oct 1;234:116739. (PMID: 31400352) ; Med War. 1990 Apr-Jun;6(2):112-9. (PMID: 2215361) ; Radiat Oncol. 2012 Oct 17;7:170. (PMID: 23072718) ; Sci Rep. 2015 Feb 04;5:8221. (PMID: 25649786) ; Neurobiol Dis. 2005 Jun-Jul;19(1-2):312-22. (PMID: 15837587) ; Eur J Pharmacol. 2009 May 1;609(1-3):40-4. (PMID: 19303870) ; Proc Jpn Acad Ser B Phys Biol Sci. 2007 Sep;83(6):151-63. (PMID: 24367141) ; J Neurosci. 2008 Aug 27;28(35):8772-84. (PMID: 18753379) ; J Ethnopharmacol. 2012 Aug 1;142(3):746-53. (PMID: 22687254) ; Pharmacol Biochem Behav. 2017 Feb;153:97-104. (PMID: 28017641) ; Int Immunopharmacol. 2015 Feb;24(2):224-231. (PMID: 25528476) ; Free Radic Res. 1999 Jan;30(1):73-83. (PMID: 10193575) ; Radiat Res. 2009 Jul;172(1):1-9. (PMID: 19580502) ; Pharmacol Biochem Behav. 2005 Dec;82(4):686-94. (PMID: 16380159) ; J Biol Chem. 2000 Jul 14;275(28):21416-21. (PMID: 10748072) ; Gerontology. 2018;64(3):229-236. (PMID: 29212073) ; Mol Endocrinol. 2009 Jan;23(1):2-10. (PMID: 19008463) ; PLoS One. 2012;7(11):e48225. (PMID: 23139766) ; Phytother Res. 2013 Sep;27(9):1368-75. (PMID: 23147754) ; Environ Sci Technol. 2014 Nov 18;48(22):13478-88. (PMID: 25332096) ; Behav Pharmacol. 2017 Aug;28(5):365-374. (PMID: 28410266) ; EMBO J. 2004 Jul 7;23(13):2586-96. (PMID: 15192701) ; Nat Rev Neurosci. 2008 Jan;9(1):65-75. (PMID: 18094707) ; Eur J Neurosci. 2003 May;17(9):1973-80. (PMID: 12752797) ; J Pharm Biomed Anal. 2016 May 10;123:63-73. (PMID: 26874256) ; Nature. 2006 Jun 15;441(7095):885-9. (PMID: 16625204) ; Biochem Pharmacol. 2020 Jun;176:113818. (PMID: 31978378) ; J Neurosci. 2007 Oct 31;27(44):11925-33. (PMID: 17978032) ; Chin Med J (Engl). 2005 Oct 5;118(19):1637-43. (PMID: 16232349) ; Int J Clin Exp Med. 2015 Nov 15;8(11):20188-97. (PMID: 26884931) ; Lancet. 2004 May 29;363(9423):1783-93. (PMID: 15172778) ; Front Pharmacol. 2019 Mar 19;10:271. (PMID: 30941046) ; Lancet. 2011 Mar 19;377(9770):1019-31. (PMID: 21371747) ; Int Immunopharmacol. 2010 Jun;10(6):668-78. (PMID: 20347053) ; Neuron. 2011 May 26;70(4):687-702. (PMID: 21609825) ; Biochem Pharmacol. 2017 Oct 1;141:143-155. (PMID: 28690138) ; J Consult Clin Psychol. 2008 Dec;76(6):909-22. (PMID: 19045960) ; Int Immunopharmacol. 2019 Aug;73:304-311. (PMID: 31128530) ; Nat Rev Mol Cell Biol. 2007 Sep;8(9):692-702. (PMID: 17700626) ; Neurosci Lett. 1992 Nov 23;147(1):58-62. (PMID: 1336152) ; Neurosci Res. 2019 Aug;145:46-53. (PMID: 30145270) ; Psychoneuroendocrinology. 2010 Feb;35(2):272-83. (PMID: 19631474) ; Phytomedicine. 2010 Oct;17(12):950-5. (PMID: 20382007) ; Neurobiol Dis. 2016 Nov;95:179-93. (PMID: 27431094) ; Life Sci. 2005 May 27;77(2):140-8. (PMID: 15862599) ; Neurosurg Clin N Am. 2007 Jan;18(1):105-13, x. (PMID: 17244558) ; J Affect Disord. 2018 Jan 15;226:155-162. (PMID: 28985587) ; Mol Aspects Med. 2006 Oct-Dec;27(5-6):403-10. (PMID: 16973211) ; Exp Gerontol. 2015 Sep;69:226-35. (PMID: 26145038) ; Am J Psychiatry. 2018 Apr 1;175(4):327-335. (PMID: 29202655) ; Front Oncol. 2015 Jan 20;4:381. (PMID: 25653923) ; Cell Biochem Biophys. 2014 Jun;69(2):303-10. (PMID: 24590261) ; Cancer Clin Trials. 1980 Summer;3(2):165-73. (PMID: 6253097) ; Neuroscience. 2015 Sep 24;304:29-35. (PMID: 26079110) ; Annu Rev Neurosci. 2005;28:223-50. (PMID: 16022595) ; Cell Death Differ. 2000 Oct;7(10):880-8. (PMID: 11279533) ; Annu Rev Genet. 1998;32:461-93. (PMID: 9928488) ; Nat Rev Drug Discov. 2012 Jun 01;11(6):443-61. (PMID: 22653216) ; Int J Biol Sci. 2019 Jan 1;15(2):277-286. (PMID: 30745820) ; Physiol Rev. 2008 Apr;88(2):611-38. (PMID: 18391175) ; Physiol Rev. 2001 Apr;81(2):741-66. (PMID: 11274343) ; Mov Disord. 2021 Jan;36(1):16-24. (PMID: 32357266) ; Mol Pharmacol. 2006 Apr;69(4):1492-8. (PMID: 16434614) ; Schizophr Res. 2005 Nov 15;79(2-3):181-8. (PMID: 16076548) ; Trends Biochem Sci. 2007 Dec;32(12):555-60. (PMID: 17980602) ; Toxicol Appl Pharmacol. 2019 Sep 15;379:114639. (PMID: 31251943) ; Int J Geriatr Psychiatry. 2006 Apr;21(4):344-8. (PMID: 16534775) ; Cell. 1995 Jun 2;81(5):727-36. (PMID: 7774014) ; Mutat Res. 2011 Mar 15;708(1-2):1-10. (PMID: 21236269) ; Med Res Rev. 2017 Sep;37(5):1186-1225. (PMID: 28084618) ; Nature. 2016 Sep 15;537(7620):427-431. (PMID: 27556946) ; Int J Radiat Biol. 2019 Aug;95(8):1094-1102. (PMID: 30831047) ; Toxicol Rep. 2019 Jun 25;6:637-644. (PMID: 31334034) ; Psychoneuroendocrinology. 2007 Aug;32 Suppl 1:S26-30. (PMID: 17629417) ; Brain Res Bull. 2017 Apr;130:180-187. (PMID: 28161197) ; Expert Opin Ther Pat. 2014 Nov;24(11):1229-55. (PMID: 25315070) ; Cell. 2006 Oct 20;127(2):397-408. (PMID: 17055439) ; Psychoneuroendocrinology. 2013 Jan;38(1):122-34. (PMID: 22663897) ; Mol Cell Biol. 2006 Nov;26(21):8122-35. (PMID: 16923962) ; Front Mol Neurosci. 2018 Jan 09;10:441. (PMID: 29375304) ; Behav Brain Res. 2016 Oct 15;313:111-119. (PMID: 27368415) ; PLoS One. 2013 Aug 15;8(8):e71347. (PMID: 23977023) ; J Neurosci. 2006 May 31;26(22):6103-14. (PMID: 16738255) ; Evid Based Complement Alternat Med. 2016;2016:4343084. (PMID: 27610184) ; Pharmacol Biochem Behav. 2011 Apr;98(2):273-8. (PMID: 21256148) ; BMC Complement Altern Med. 2018 Jan 29;18(1):34. (PMID: 29378551) ; CNS Neurosci Ther. 2016 Jan;22(1):63-73. (PMID: 26584824) ; Biosci Rep. 2019 Jul 25;39(7):. (PMID: 31296789) ; Mil Med. 2002 Feb;167(2 Suppl):134-6. (PMID: 11873498) ; Clin Exp Pharmacol Physiol. 2007 Aug;34(8):792-5. (PMID: 17600559) ; Front Pharmacol. 2018 May 30;9:531. (PMID: 29899697) ; Cell Stem Cell. 2018 Jul 05;23(1):25-30. (PMID: 29681514) ; PLoS One. 2017 Apr 28;12(4):e0176725. (PMID: 28453574) ; Dose Response. 2020 Oct 30;18(4):1559325820970810. (PMID: 33192204) ; N Engl J Med. 2018 Jan 11;378(2):169-180. (PMID: 29320652) ; Cell. 2008 Feb 22;132(4):645-60. (PMID: 18295581) ; Exp Gerontol. 2003 Jan-Feb;38(1-2):61-9. (PMID: 12543262) ; Int J Biol Sci. 2014 Jan 21;10(2):181-91. (PMID: 24550686) ; Phytother Res. 2008 May;22(5):597-604. (PMID: 18398927) ; Biochem Biophys Res Commun. 2008 Nov 14;376(2):251-5. (PMID: 18774777) ; Int J Nanomedicine. 2020 May 07;15:3251-3266. (PMID: 32440122) ; Life Sci. 2020 Aug 15;255:117847. (PMID: 32470450) ; Neurochem Res. 2013 Sep;38(9):1769-73. (PMID: 23737325) ; Brain Res Bull. 2021 Oct;175:37-47. (PMID: 34274431) ; J Ethnopharmacol. 2011 Apr 12;134(3):519-41. (PMID: 21215308) ; J Pathol. 2009 Jan;217(2):242-53. (PMID: 19040211) ; Neuron. 2003 Sep 11;39(6):889-909. (PMID: 12971891) ; Br J Pharmacol. 2008 Mar;153 Suppl 1:S112-9. (PMID: 18311155) ; Neuroscience. 2015 May 21;294:193-205. (PMID: 25791226) ; FASEB J. 2020 Jan;34(1):1783-1801. (PMID: 31914584) ; Science. 2010 Jan 29;327(5965):542-5. (PMID: 20110496) ; Ethn Dis. 2002 Winter;12(1):S28-30. (PMID: 11913654) ; Nat Rev Neurol. 2017 May;13(5):260. (PMID: 28338075) ; Pharm Biol. 2021 Dec;59(1):183-191. (PMID: 33556283) ; Pharmacol Res. 2021 Jun;168:105587. (PMID: 33798737) ; Front Pharmacol. 2020 Jan 31;10:1660. (PMID: 32082160) ; Cell Commun Signal. 2013 Aug 29;11:65. (PMID: 23987506) ; Alzheimers Res Ther. 2012 Sep 21;4(5):40. (PMID: 22995353) ; FEBS J. 2018 Oct;285(19):3576-3590. (PMID: 29323772) ; Int J Epidemiol. 1990 Sep;19(3):546-52. (PMID: 2262246) ; Neurosignals. 2002 Sep-Oct;11(5):270-81. (PMID: 12566928) ; Pharmacol Biochem Behav. 2015 Nov;138:40-8. (PMID: 26364923) ; Eur J Pharmacol. 2020 Oct 15;885:173523. (PMID: 32871176) ; Vascul Pharmacol. 2015 Nov;74:38-48. (PMID: 26025205) ; Biomed Res Int. 2017;2017:7464872. (PMID: 29057264) ; Biol Psychiatry. 2021 Apr 15;89(8):745-756. (PMID: 32223911) ; Evid Based Complement Alternat Med. 2015;2015:235265. (PMID: 25705234) ; J Clin Biochem Nutr. 2007 Mar;40(2):74-81. (PMID: 18188408) ; Eur J Pharmacol. 2010 Jan 25;626(2-3):213-8. (PMID: 19782061) ; J Biol Chem. 2009 Aug 7;284(32):21379-85. (PMID: 19542216) ; Phytomedicine. 2017 Feb 15;25:93-99. (PMID: 28190476) ; Pharmaceutics. 2020 Apr 11;12(4):. (PMID: 32290412) ; PLoS One. 2014 Sep 03;9(9):e106302. (PMID: 25184226) ; Neural Regen Res. 2022 Mar;17(3):632-642. (PMID: 34380904) ; Histol Histopathol. 2013 Mar;28(3):301-10. (PMID: 23348383) ; PeerJ. 2020 Apr 20;8:e8955. (PMID: 32341897) ; Eur J Med Genet. 2018 Sep;61(9):556-563. (PMID: 29908351) Contributed Indexing: Keywords: ageing; icariin; neuroinflammation; oxidative stress; radio-neuro-protective effect Substance Nomenclature: 0 (Flavonoids) ; 0 (Neuroprotective Agents) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20220215 Date Completed: 20220413 Latest Revision: 20220413 Update Code: 20240513 PubMed Central ID: PMC8876913

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The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure.