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Alzheimer's disease (AD) is a neurodegenerative disease characterized by excessive deposition of β amyloid (Aβ), hyperphosphorylation of tau protein, and neuronal cell death. Recent studies have shown that myelin cell damage, which leads to cognitive dysfunction, occurs before AD-related pathological changes. Here, we examine the effect of icariin (ICA), a prenylated flavonol glycoside, in improving cognitive function in AD model mice. ICA has been reported to exhibit cardiovascular protective functions and antiaging effects. In this study, we used 3 × Tg-AD mice as an AD model. The Morris water maze and Y maze tests were performed to assess the learning and memory of the mice. Immunofluorescence analysis of Aβ1-42 deposition and myelin basic protein (MBP) expression in the mouse hippocampus was performed. Tau protein phosphorylation and MBP protein expression in the hippocampus were further analyzed by Western blotting. Myelin damage in the mouse optic nerve was evaluated by electron microscopy, and LFB staining was performed to assess myelin morphology in the mouse corpus callosum. MBP, Mpp5, and Egr2 transcript levels were quantified by qPCR. We observed that ICA treatment improved the learning and memory of 3 × Tg-AD mice and reduced Aβ deposition and tau protein phosphorylation in the hippocampus. Moreover, this treatment protocol increased myelin-related gene expression and reduced myelin damage.

Titel:	Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice.
Autor/in / Beteiligte Person:	Yu, H ; Shi, J ; Lin, Y ; Zhang, Y ; Luo, Q ; Huang, S ; Wang, S ; Wei, J ; Huang, J ; Li, C ; Ji, L
Link:	Zum Volltext
Zeitschrift:	Neurochemical research, Jg. 47 (2022-04-01), Heft 4, S. 1049-1059
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press, 2022
Medientyp:	academicJournal
ISSN:	1573-6903 (electronic)
DOI:	10.1007/s11064-021-03507-7
Schlagwort:	Amyloid beta-Peptides metabolism Animals Disease Models, Animal Flavonoids Hippocampus metabolism Maze Learning Mice Mice, Transgenic Myelin Sheath metabolism tau Proteins metabolism Alzheimer Disease metabolism Neurodegenerative Diseases metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Neurochem Res] 2022 Apr; Vol. 47 (4), pp. 1049-1059. <i>Date of Electronic Publication: </i>2022 Jan 17. MeSH Terms: Alzheimer Disease* / metabolism ; Neurodegenerative Diseases* / metabolism ; Amyloid beta-Peptides / metabolism ; Animals ; Disease Models, Animal ; Flavonoids ; Hippocampus / metabolism ; Maze Learning ; Mice ; Mice, Transgenic ; Myelin Sheath / metabolism ; tau Proteins / metabolism References: Lane CA, Hardy J, Schott JM (2018) Alzheimer’s disease. Eur J Neurol 25:59–70. (PMID: 28872215) ; Alzheimer’s Association Report (2020) 2020 Alzheimer’s disease facts and figures. Alzheimers Dement. https://doi.org/10.1002/alz.12068. (PMID: 10.1002/alz.12068) ; Marucci G, Buccioni M, Ben DD, Lambertucci C, Volpini R, Amenta F (2020) Efficacy of acetylcholinesterase inhibitors in Alzheimer’s disease. Neuropharmacology 190:108352. 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Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice.