Einzeltreffer — DigiBib

Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such as nociception, neurotensin or β-defensin 2. Interacting with peptide receptors located in the lungs or on immune cells opens up new therapeutic possibilities for the treatment of asthma, especially when it is resistant to available therapies. This article provides a concise review of the most important and current findings regarding the involvement of regulatory peptides in asthma pathology.

Titel:	Regulatory Peptides in Asthma.
Autor/in / Beteiligte Person:	Kaczyńska, K ; Zając, D ; Wojciechowski, P ; Jampolska, M
Link:	Zum Volltext
Zeitschrift:	International journal of molecular sciences, Jg. 22 (2021-12-20), Heft 24
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2021
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms222413656
Schlagwort:	Animals Gene Expression Regulation Humans Neuropeptide Y metabolism Neurotensin metabolism Tachykinins metabolism beta-Defensins metabolism Asthma metabolism Peptides metabolism Receptors, Peptide metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). <i>Date of Electronic Publication: </i>2021 Dec 20. MeSH Terms: Asthma / metabolism ; Peptides / metabolism ; Receptors, Peptide / *metabolism ; Animals ; Gene Expression Regulation ; Humans ; Neuropeptide Y / metabolism ; Neurotensin / metabolism ; Tachykinins / metabolism ; beta-Defensins / metabolism References: Biochem Biophys Res Commun. 2018 May 15;499(3):655-661. (PMID: 29604272) ; J Appl Physiol (1985). 2012 May;112(10):1637-43. (PMID: 22345430) ; Eur Respir J. 2012 Feb;39(2):458-66. (PMID: 21828035) ; Pharmaceuticals (Basel). 2021 May 19;14(5):. (PMID: 34069327) ; Am J Respir Crit Care Med. 2002 Apr 15;165(8):1071-5. (PMID: 11956047) ; Am J Respir Cell Mol Biol. 2015 Sep;53(3):303-13. (PMID: 25569618) ; Respir Med. 2020 Aug - Sep;170:106063. (PMID: 32705985) ; Am J Respir Cell Mol Biol. 1995 Sep;13(3):288-96. 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(PMID: 11937559) Contributed Indexing: Keywords: airway hyperreactivity; asthma; inflammation; regulatory peptides Substance Nomenclature: 0 (Neuropeptide Y) ; 0 (Peptides) ; 0 (Receptors, Peptide) ; 0 (Tachykinins) ; 0 (beta-Defensins) ; 39379-15-2 (Neurotensin) Entry Date(s): Date Created: 20211224 Date Completed: 20220128 Latest Revision: 20220128 Update Code: 20240513 PubMed Central ID: PMC8707337

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Regulatory Peptides in Asthma.