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Background: Knee osteoarthritis (KOA) is a chronic degenerative disease involving cartilage and surrounding tissues. It causes a huge burden to social and medical resources and seriously affects people's living and working ability. In recent years, people have become increasingly interested in the application of Chinese medicine monomers to treat KOA. Among them, icariin plays an important role in the clinical treatment of KOA. Therefore, to evaluate the effectiveness and safety of icariin in the treatment of KOA, we conducted this study to provide a new basis for the clinical treatment of KOA.

Methods: We propose a systematic search of the PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and China Biomedical databases for all randomized controlled trials examining the use of icariin in the treatment of KOA patients up to October 20, 2021. The screening and data extraction processes will be performed independently by 2 researchers. We will use the Cochrane risk bias assessment tool to evaluate the quality of the studies that met the inclusion criteria. The data will be statistically analyzed using RevMan5.3 software.

Result: This study will provide high-quality evidence for the effectiveness and safety of icariin in the treatment of KOA.

Conclusion: The purpose of this study was to explore the efficacy of icariin in the treatment of KOA and to provide clinicians and patients with new treatment strategies.

Inplasy Registration Number: INPLASY2021110015.

Competing Interests: The authors have no conflicts of interest to disclose.

Titel:	Evaluation of the effectiveness and safety of icariin in the treatment of knee osteoarthritis: A protocol for a systematic review and meta-analysis.
Autor/in / Beteiligte Person:	Liu, L ; Zhao, C ; Zhao, S ; Xu, H ; Peng, Z ; Zhang, B ; Cai, W ; Mo, Y ; Zhao, W
Link:	Zum Volltext
Zeitschrift:	Medicine, Jg. 100 (2021-12-17), Heft 50, S. e28277
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2021
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000028277
Schlagwort:	Flavonoids Humans Meta-Analysis as Topic Systematic Reviews as Topic Acupuncture Therapy Drugs, Chinese Herbal Osteoarthritis, Knee therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Medicine (Baltimore)] 2021 Dec 17; Vol. 100 (50), pp. e28277. MeSH Terms: Acupuncture Therapy* ; Drugs, Chinese Herbal* ; Osteoarthritis, Knee / *therapy ; Flavonoids ; Humans ; Meta-Analysis as Topic ; Systematic Reviews as Topic References: Wiggers TG, Winters M, Van den Boom NA, Haisma HJ, Moen MH. Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials. Br J Sports Med 2021;55:1161–9. ; Li X, Xu Y, Li H, et al. Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis. Biomed Pharmacother 2021;144:112259. ; Betzler BK, Chee YJ, Bin Abd Razak HR. Intraosseous injections are safe and effective in knee osteoarthritis: a systematic review. Arthrosc Sports Med Rehabil 2021;3:e1557–67. ; Hawker GA. Osteoarthritis is a serious disease. Clin Exp Rheumatol 2019;120:03–6. ; Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine 2020;29-30:100587. ; Primorac D, Molnar V, Rod E, et al. Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations. Genes 2020;11:854. ; Koh SM, Chan CK, Teo SH, et al. Elevated plasma and synovial fluid interleukin-8 and interleukin-18 may be associated with the pathogenesis of knee osteoarthritis. Knee 2020;27:26–35. ; Reginster JY, Veronese N. Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment. Aging Clin Exp Res 2021;33:37–47. ; Krishnamurthy A, Lang AE, Pangarkar S, Edison J, Cody J, Sall J. Synopsis of the 2020 US Department of Veterans Affairs/US Department of Defense Clinical Practice Guideline: the non-surgical management of hip and knee osteoarthritis. Mayo Clin Proc 2021;96:2435–47. ; Sharon L, Kolasinski, Tuhina Neogi, Marc C, Hochberg, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res 2020;72:220–33. ; Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA 2021;325:568–78. ; Yao B, Zhou Z, Zhang M, Leng X, Zhao D. Investigating the molecular control of deer antler extract on articular cartilage. J Orthop Surg Res 2021;16:08. ; Wang Z, Wang D, Yang D, Zhen W, Zhang J, Peng S. The effect of icariin on bone metabolism and its potential clinical application. Osteoporos Int 2018;29:535–44. ; Ming LG, Chen KM, Xian CJ. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J Cell Physiol 2013;228:513–21. ; Fan JJ, Cao LG, Wu T, et al. The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells. Molecules 2011;16:10123–33. ; Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;350:g7647–72. ; Castrogiovanni P, Di Rosa M, Ravalli S, et al. Moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key. Int J Mol Sci 2019;20:511. ; Rezuş E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezuş C. From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int J Mol Sci 2021;22:2697. ; Rezuş E, Cardoneanu A, Burlui A, et al. The link between inflammaging and degenerative joint diseases. Int J Mol Sci 2019;20:614. ; Singh WR, Sharma A, Devi HS, Bhatia A, Patel MR, Kumar D. Icariin improves cutaneous wound healing in streptozotocin-induced diabetic rats. J Tissue Viability 2021. ; Zhang D, Fong C, Jia Z, Cui L, Yao X, Yang M. Icariin stimulates differentiation and suppresses adipocytic transdifferentiation of primary osteoblasts through estrogen receptor-mediated pathway. Calcif Tissue Int 2016;99:187–98. ; Yu H, Yue J, Wang W, et al. Icariin promotes angiogenesis in glucocorticoid-induced osteonecrosis of femoral heads: in vitro and in vivo studies. J Cell Mol Med 2019;23:7320–30. Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20211217 Date Completed: 20220214 Latest Revision: 20230103 Update Code: 20231215 PubMed Central ID: PMC8678024

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Evaluation of the effectiveness and safety of icariin in the treatment of knee osteoarthritis: A protocol for a systematic review and meta-analysis.