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Metabolic syndrome (MetS) is an immense health issue that causes serious complications in aging males including BPH. Icariin (ICA) is a flavonol glycoside that exerts a plethora of pharmacological effects. The present investigation tested the potential of ICA to ameliorate benign prostatic hyperplasia (BPH) induced by MetS in rats. Animals were allocated to 5 groups in which the first and second groups were kept on water and regular food pellets. MetS was induced in the third, fourth, and fifth groups by keeping the animals on high fructose and salt diets for twelve consecutive weeks. These groups were given vehicle, ICA (25 mg/kg), and ICA (50 mg/kg), respectively. MetS was confirmed by an increase in rats' weight, accumulation of visceral fat, insulin resistance, and dyslipidemia. This was accompanied by manifestation of BPH including increased prostate weight, prostate index, and histopathological alterations. Treating the animals with both doses of ICA significantly ameliorated the increase in weight and index of the prostate as well as altered prostate histopathology. In addition, ICA significantly decreased cyclin D1 expression, upregulated Bax, and downregulated Bcl2 mRNA expression. ICA prevented lipid peroxidation, reduced glutathione depletion, and catalase exhaustion, which further lowered markers of prostate inflammation such as interleukin-6 and tumor necrosis factor-α. Moreover, ICA prevented the decrease in prostate content of phosphorylated 5'-adenosine monophosphate (AMP)-activated protein kinase (pAMPK). In conclusion, ICA protects against MetS-induced BPH. This is due to its antiproliferative, proapoptotic, antioxidant, and anti-inflammatory activities as well as the activation of AMPK.

Titel:	Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats.
Autor/in / Beteiligte Person:	Aljehani, AA ; Albadr, NA ; Nasrullah, MZ ; Neamatallah, T ; Eid, BG ; Abdel-Naim, AB
Link:	Zum Volltext
Zeitschrift:	Environmental science and pollution research international, Jg. 29 (2022-03-01), Heft 14, S. 20370-20378
Veröffentlichung:	<2013->: Berlin : Springer ; <i>Original Publication</i>: Landsberg, Germany : Ecomed, 2022
Medientyp:	academicJournal
ISSN:	1614-7499 (electronic)
DOI:	10.1007/s11356-021-17245-4
Schlagwort:	Animals Flavonoids Male Prostate metabolism Prostate pathology Rats Testosterone metabolism Metabolic Syndrome Prostatic Hyperplasia drug therapy Prostatic Hyperplasia metabolism Prostatic Hyperplasia pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Environ Sci Pollut Res Int] 2022 Mar; Vol. 29 (14), pp. 20370-20378. <i>Date of Electronic Publication: </i>2021 Nov 04. MeSH Terms: Metabolic Syndrome* ; Prostatic Hyperplasia* / drug therapy ; Prostatic Hyperplasia* / metabolism ; Prostatic Hyperplasia* / pathology ; Animals ; Flavonoids ; Male ; Prostate / metabolism ; Prostate / pathology ; Rats ; Testosterone / metabolism References: Aaron-Brooks LTM, Sasaki T, Vickman RE et al (2019) Hyperglycemia and T cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse. Prostate 79:980–993. https://doi.org/10.1002/pros.23809. (PMID: 10.1002/pros.23809) ; Abdallah HM, El-Bassossy HM, Mohamed GA et al (2016) Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome through direct vasodilatation and nitric oxide generation. 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Icariin ameliorates metabolic syndrome-induced benign prostatic hyperplasia in rats.