Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers.
In: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 112 (2021-11-01), S. 165
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Objective: Uganda has registered fewer coronavirus disease 2019 (COVID-19) cases and deaths per capita than Western countries. The lower numbers of cases and deaths might be due to pre-existing cross-immunity induced by circulating common cold human coronaviruses (HCoVs) before the COVID-19 pandemic. To investigate pre-existing mucosal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, a comparison was performed of IgA reactivity to SARS-CoV-2 and HCoVs in milk from mothers collected in 2018.
Methods: Ugandan and United States milk samples were run on an ELISA to measure specific IgA to SARS-CoV-2 and HCoVs NL63, OC43, HKU1, and 229E spike proteins. Pooled plasma from United States SARS-CoV-2-positive and negative cases were positive and negative controls, respectively.
Results: One Ugandan mother had high milk IgA reactivity against all HCoVs and SARS-CoV-2 spike proteins. Ugandan mothers had significantly higher IgA reactivity against the betacoronavirus HCoV-OC43 than United States mothers (P = 0.018). By contrast, United States mothers had significantly higher IgA reactivity against the alphacoronaviruses HCoV-229E and HCoV-NL63 than Ugandan mothers (P < 0.0001 and P = 0.035, respectively).
Conclusion: Some Ugandan mothers have pre-existing HCoV-induced IgA antibodies against SARS-CoV-2, which may be passed to infants via breastfeeding.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers.
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| Autor/in / Beteiligte Person: | Egwang, TG ; Owalla, TJ ; Okurut, E ; Apungia, G ; Fox, A ; De Carlo, C ; Powell, RL |
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| Zeitschrift: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 112 (2021-11-01), S. 165 |
| Veröffentlichung: | Hamilton, ON : Elsevier ; <i>Original Publication</i>: Hamilton, ON : Decker, c1996-, 2021 |
| Medientyp: | academicJournal |
| ISSN: | 1878-3511 (electronic) |
| DOI: | 10.1016/j.ijid.2021.09.039 |
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