The interplay between 5-HT <subscript>2C</subscript> and 5-HT <subscript>3A</subscript> receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice.

Lopes, LT ; Canto-de-Souza, L ; et al.

In: Behavioural brain research, Jg. 417 (2022-01-24), S. 113588

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The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT 2C receptors (5-HT 2C R) expressed in the dorsal periaqueductal gray (dPAG). Here, we investigated the presence of 5-HT 3A receptors (5-HT 3A R) in the dPAG, and the interplay between 5-HT 2C R and 5-HT 3A R in the dPAG in mediating anxiety-like behavior in mice. We found that 5-HT 3A R is expressed in the dPAG and the blockade of these receptors using intra-dPAG infusion of ondansetron (5-HT 3A R antagonist; 3.0 nmol) induced an anxiogenic-like effect. The activation of 5-HT 3AB R by the infusion of mCPBG [1-(m-Chlorophenyl)-biguanide; 5-HT 3 R agonist] did not alter anxiety-like behaviors. In addition, blockade of 5-HT 3A R (1.0 nmol) prevented the anxiolytic-like effect induced by the infusion of the 5-HT 2C R agonist mCPP (1-(3-chlorophenyl) piperazine; 0.03 nmol). None of the treatment effects on anxiety-like behaviors altered the locomotor activity levels. The present results suggest that the anxiolytic-like effect exerted by serotonin activity on 5-HT 2C R in the dPAG is modulated by 5-HT 3A R expressed in same region.

Titel:	The interplay between 5-HT <subscript>2C</subscript> and 5-HT <subscript>3A</subscript> receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice.
Autor/in / Beteiligte Person:	Lopes, LT ; Canto-de-Souza, L ; Baptista-de-Souza, D ; de Souza RR ; Nunes-de-Souza, RL ; Canto-de-Souza, A
Link:	Zum Volltext
Zeitschrift:	Behavioural brain research, Jg. 417 (2022-01-24), S. 113588
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2022
Medientyp:	academicJournal
ISSN:	1872-7549 (electronic)
DOI:	10.1016/j.bbr.2021.113588
Schlagwort:	Animals Behavior, Animal drug effects Male Mice Ondansetron antagonists & inhibitors Piperazines Anxiety physiopathology Biguanides metabolism Ondansetron pharmacology Periaqueductal Gray metabolism Receptor, Serotonin, 5-HT2C metabolism Receptors, Serotonin, 5-HT3 metabolism Serotonin metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Behav Brain Res] 2022 Jan 24; Vol. 417, pp. 113588. <i>Date of Electronic Publication: </i>2021 Sep 20. MeSH Terms: Anxiety / physiopathology ; Biguanides / metabolism ; Ondansetron / pharmacology ; Periaqueductal Gray / metabolism ; Receptor, Serotonin, 5-HT2C / metabolism ; Receptors, Serotonin, 5-HT3 / metabolism ; Serotonin / *metabolism ; Animals ; Behavior, Animal / drug effects ; Male ; Mice ; Ondansetron / antagonists & inhibitors ; Piperazines Contributed Indexing: Keywords: 5-HT(3A) and 5-HT(2C) receptors; Elevated Plus-Maze (EPM); MCPBG; MCPP; Mice; Ondansetron Substance Nomenclature: 0 (Biguanides) ; 0 (Piperazines) ; 0 (Receptor, Serotonin, 5-HT2C) ; 0 (Receptors, Serotonin, 5-HT3) ; 333DO1RDJY (Serotonin) ; 4AF302ESOS (Ondansetron) ; 910A4X901V (1-(3-chlorophenyl)biguanide) ; REY0CNO998 (1-(3-chlorophenyl)piperazine) Entry Date(s): Date Created: 20210921 Date Completed: 20220318 Latest Revision: 20220318 Update Code: 20240513

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