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Introduction: approximately 6000 Cameroonian women died of cancer in 2018, and the breast is the most affected with 2625 new cases. The aim of this study was to establish a pattern of malignant breast tumours in Yaoundé (Cameroon).

Methods: this study was a descriptive and analytical retrospective study of breast cancer between January 2010 and December 2015 in Yaoundé General Hospital (YGH) after the Institutional ethics committee approval. The variables studied were the socio-demographic characteristics, risk factors for breast cancer, types of tumours and type of treatments. The 5-year survival was analyzed by the Kaplan-Meier method. The adjusted hazard ratios and their 95% confidence intervals were calculated to assess the association between studied variables and patient survival through the cox regression using SPSS 23 software. The difference was considered significant at p < 0.05.

Results: among the 344 files collected in this study, breast cancer patients were predominantly female (96.64%, n = 288) aged 45.39 ± 13.35 years, with invasive ductal carcinoma (68.03%, n = 270), located in the left breast (52%, n= 147). The average tumour size was ~6.5 ± 0.3 cm and diagnosed in grade II of Scarf Bloom Richardson (SBR) in 60% (n= 150) of cases. The 5-year survival was 43.3%. Factors associated with this poor survival were the religion (aHR 5.05, 95% CI: 1.57 - 16.25; p = 0.007 for animist and aHR 4.2, 95% CI: 1.53 - 11.46; p = 0.005 for protestant), location of the tumour (aHR 6.24, 95% CI: 1.58 - 24.60; p = 0.012), tumor height (aHR 0.21, 95% CI: 0.04 - 1.11; p = 0.011) and the time spent before medical treatment (aHR 5.12, 95% CI: 0.39 - 8.38; p = 0.011).

Conclusion: the young age, large tumour size and high histological grade in our studied population suggest a weak awareness of women about breast cancer. Action should be taken in early screening to improve the management of breast cancer in Cameroon.

Competing Interests: The authors declare no competing interests.

(Copyright: Stéphane Zingue et al.)

Titel:	Epidemiological and clinical profile, and survival of patients followed for breast cancer between 2010 and 2015 at the Yaounde General Hospital, Cameroon.
Autor/in / Beteiligte Person:	Zingue, S ; Atenguena, EO ; Zingue, LL ; Tueche, AB ; Njamen, D ; Nkoum, AB ; Ndom, P
Link:	Zum Volltext
Zeitschrift:	The Pan African medical journal, Jg. 39 (2021-07-07), S. 182
Veröffentlichung:	Kampala, Uganda : African Field Epidemiology Network, 2021
Medientyp:	academicJournal
ISSN:	1937-8688 (electronic)
DOI:	10.11604/pamj.2021.39.182.26866
Schlagwort:	Adolescent Adult Aged Aged, 80 and over Breast Neoplasms diagnosis Breast Neoplasms pathology Breast Neoplasms, Male diagnosis Breast Neoplasms, Male pathology Cameroon epidemiology Carcinoma, Ductal, Breast diagnosis Carcinoma, Ductal, Breast pathology Early Detection of Cancer methods Female Hospitals, General Humans Male Middle Aged Neoplasm Grading Retrospective Studies Risk Factors Survival Rate Young Adult Breast Neoplasms epidemiology Breast Neoplasms, Male epidemiology Carcinoma, Ductal, Breast epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pan Afr Med J] 2021 Jul 07; Vol. 39, pp. 182. <i>Date of Electronic Publication: </i>2021 Jul 07 (<i>Print Publication: </i>2021). MeSH Terms: Breast Neoplasms / epidemiology ; Breast Neoplasms, Male / epidemiology ; Carcinoma, Ductal, Breast / *epidemiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms / diagnosis ; Breast Neoplasms / pathology ; Breast Neoplasms, Male / diagnosis ; Breast Neoplasms, Male / pathology ; Cameroon / epidemiology ; Carcinoma, Ductal, Breast / diagnosis ; Carcinoma, Ductal, Breast / pathology ; Early Detection of Cancer / methods ; Female ; Hospitals, General ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Retrospective Studies ; Risk Factors ; Survival Rate ; Young Adult References: Mali Med. 2013;28(1):1-5. (PMID: 29925213) ; CA Cancer J Clin. 2019 Jan;69(1):7-34. (PMID: 30620402) ; CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593) ; Pan Afr Med J. 2015 Aug 04;21:242. (PMID: 26523182) ; Bull Cancer. 2011 Jul;98(7):797-806. (PMID: 21700549) ; J Glob Health. 2018 Jun;8(1):010419. (PMID: 29740502) Contributed Indexing: Keywords: Breast cancer; Yaoundé General Hospital; clinical profile; epidemiological profile; overall survival Entry Date(s): Date Created: 20210901 Date Completed: 20210909 Latest Revision: 20220426 Update Code: 20231215 PubMed Central ID: PMC8378266

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Epidemiological and clinical profile, and survival of patients followed for breast cancer between 2010 and 2015 at the Yaounde General Hospital, Cameroon.