Einzeltreffer — DigiBib

Icariin is a biologically active substance in Epimedii herba that is used for the treatment of neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of icariin is lacking. In this review, we present a brief history of the use of icariin for medicinal purposes; describe the active chemical components of Epimedii herba ; and examine the evidence from experimental studies that have uncovered molecular targets of icariin in different diseases. We also constructed a protein-protein interaction network and carried out Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analyses to predict the therapeutic actions of icariin in nervous system diseases including Alzheimer disease, Parkinson disease, ischemic stroke, depressive disorder, multiple sclerosis, glioblastoma, and hereditary spastic paraplegias. The results of our analyses can guide future studies on the application of icariin to the treatment of neurologic disorders.

Competing Interests: The authors report no conflicts of interest in this work.

Titel:	Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review.
Autor/in / Beteiligte Person:	Wang, S ; Ma, J ; Zeng, Y ; Zhou, G ; Wang, Y ; Zhou, W ; Sun, X ; Wu, M
Link:	Zum Volltext
Zeitschrift:	Drug design, development and therapy, Jg. 15 (2021-08-20), S. 3619
Veröffentlichung:	[Auckland, N.Z.] : Dove Press Limited, 2021
Medientyp:	academicJournal
ISSN:	1177-8881 (electronic)
DOI:	10.2147/DDDT.S310686
Schlagwort:	Animals Flavonoids isolation & purification Humans Molecular Targeted Therapy Nervous System Diseases physiopathology Network Pharmacology Protein Interaction Maps Drugs, Chinese Herbal chemistry Flavonoids pharmacology Nervous System Diseases drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Drug Des Devel Ther] 2021 Aug 20; Vol. 15, pp. 3619-3641. <i>Date of Electronic Publication: </i>2021 Aug 20 (<i>Print Publication: </i>2021). MeSH Terms: Drugs, Chinese Herbal / chemistry ; Flavonoids / pharmacology ; Nervous System Diseases / *drug therapy ; Animals ; Flavonoids / isolation & purification ; Humans ; Molecular Targeted Therapy ; Nervous System Diseases / physiopathology ; Network Pharmacology ; Protein Interaction Maps References: J Neuroinflammation. 2019 May 10;16(1):98. (PMID: 31077217) ; Diagnostics (Basel). 2020 Mar 24;10(3):. (PMID: 32214002) ; Home Healthc Now. 2016 Jun;34(6):300-7. (PMID: 27243427) ; Front Mol Neurosci. 2014 May 21;7:46. (PMID: 24904272) ; Biomed Pharmacother. 2019 Sep;117:109077. (PMID: 31177064) ; Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 7;52(6):458-462. (PMID: 28635220) ; Int Immunopharmacol. 2016 Jan;30:157-162. (PMID: 26679678) ; Nutrients. 2019 May 18;11(5):. (PMID: 31109081) ; Transl Res. 2016 Jun;172:18-29.e2. (PMID: 26924042) ; J Neuroinflammation. 2018 Nov 23;15(1):326. (PMID: 30470240) ; J Neuropathol Exp Neurol. 2019 Mar 1;78(3):268-282. (PMID: 30715406) ; Biomol Ther (Seoul). 2012 Mar;20(2):189-95. (PMID: 24116294) ; Evid Based Complement Alternat Med. 2018 Nov 26;2018:2767208. (PMID: 30598683) ; CNS Neurol Disord Drug Targets. 2014;13(5):745-54. (PMID: 24365184) ; J Chromatogr A. 2002 Jul 12;962(1-2):239-41. (PMID: 12198968) ; Alzheimers Dement. 2019 Jul;15(7):961-984. (PMID: 31327392) ; Clin Exp Pharmacol Physiol. 2015 Dec;42(12):1296-307. (PMID: 26356761) ; Front Pharmacol. 2017 Oct 12;8:734. (PMID: 29075193) ; Molecules. 2010 Nov 03;15(11):7861-70. (PMID: 21060294) ; Neurobiol Aging. 2013 Apr;34(4):1051-9. (PMID: 23062700) ; Brain Dev. 2017 Aug;39(7):593-600. (PMID: 28395974) ; Mol Cells. 2017 Sep 30;40(9):613-620. (PMID: 28927263) ; Arzneimittelforschung. 1995 Aug;45(8):910-3. (PMID: 7575760) ; Front Endocrinol (Lausanne). 2019 Jul 23;10:494. (PMID: 31396157) ; Bioinformatics. 2009 Apr 15;25(8):1091-3. (PMID: 19237447) ; Mar Drugs. 2017 Jan 04;15(1):. (PMID: 28054961) ; Stroke. 2017 May;48(5):1438-1440. (PMID: 28411262) ; Phytomedicine. 2016 Jun 15;23(7):784-92. (PMID: 27180226) ; Curr Alzheimer Res. 2017;14(4):412-425. (PMID: 27697064) ; Curr Alzheimer Res. 2012 Sep;9(7):864-79. (PMID: 22272620) ; Mult Scler Relat Disord. 2017 Jul;15:37-41. (PMID: 28641771) ; Front Physiol. 2017 May 29;8:342. (PMID: 28611679) ; Int J Cardiol. 2019 Apr 1;280:152-159. (PMID: 30679074) ; Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:83-93. (PMID: 24334212) ; FEBS Open Bio. 2021 Jan;11(1):322-332. (PMID: 33159388) ; Eur J Pharmacol. 2019 Jan 5;842:20-32. (PMID: 30342950) ; J Ethnopharmacol. 2016 Nov 4;192:370-381. (PMID: 27422162) ; Nature. 2016 Nov 30;540(7631):S1. (PMID: 27902684) ; Molecules. 2019 Oct 15;24(20):. (PMID: 31618892) ; Molecules. 2017 Apr 17;22(4):. (PMID: 28420179) ; J Orthop Surg Res. 2019 Sep 11;14(1):307. (PMID: 31511005) ; Mol Neurobiol. 2016 Aug;53(6):3626-3645. (PMID: 26108185) ; Behav Brain Res. 2018 Feb 26;339:57-65. (PMID: 29158110) ; Cell Physiol Biochem. 2018;49(6):2138-2150. (PMID: 30257237) ; Neoplasia. 2010 Sep;12(9):675-84. (PMID: 20824044) ; Curr Aging Sci. 2017;10(3):158-176. (PMID: 28302047) ; Cerebellum. 2017 Apr;16(2):525-551. (PMID: 27271711) ; Int J Neuropsychopharmacol. 2014 Jun;17(6):871-81. (PMID: 24513083) ; Evid Based Complement Alternat Med. 2017;2017:8085325. (PMID: 29445413) ; Nucleic Acids Res. 2018 Mar 16;46(5):2699. (PMID: 29425356) ; Int J Mol Med. 2016 Jul;38(1):337-44. (PMID: 27221032) ; Cell Biochem Biophys. 2015 Apr;71(3):1379-85. (PMID: 25384619) ; Int J Mol Sci. 2020 Jan 09;21(2):. (PMID: 31936558) ; Regen Biomater. 2016 Dec;3(4):257-67. (PMID: 27482467) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Feb 15;34(2):206-212. (PMID: 32030953) ; OMICS. 2012 May;16(5):284-7. (PMID: 22455463) ; Int J Mol Sci. 2018 Jan 26;19(2):. (PMID: 29373539) ; Am J Transl Res. 2016 Apr 15;8(4):1910-8. (PMID: 27186315) ; Oncol Lett. 2017 Oct;14(4):5027-5033. (PMID: 29085516) ; Front Aging Neurosci. 2019 Oct 04;11:271. (PMID: 31636558) ; Nat Rev Dis Primers. 2018 Nov 8;4(1):44. (PMID: 30410088) ; Chin J Traumatol. 2020 Apr;23(2):96-101. (PMID: 32201231) ; J Neuroinflammation. 2019 Apr 22;16(1):92. (PMID: 31010422) ; Dialogues Clin Neurosci. 2009;11(3):239-55. (PMID: 19877493) ; Life Sci. 2019 Dec 15;239:116879. (PMID: 31682849) ; Lancet Neurol. 2019 Dec;18(12):1136-1146. (PMID: 31377012) ; Int Immunopharmacol. 2018 Dec;65:64-75. (PMID: 30290368) ; Semin Cell Dev Biol. 2018 Aug;80:50-64. (PMID: 28587975) ; J Affect Disord. 2015 Oct 1;185:149-55. (PMID: 26186530) ; Transl Psychiatry. 2018 Oct 11;8(1):216. (PMID: 30310078) ; Parkinsonism Relat Disord. 2019 Jun;63:156-161. (PMID: 30796009) ; Mol Neurobiol. 2018 Jul;55(7):6063-6075. (PMID: 29164394) ; Nat Commun. 2017 Jan 30;8:14290. (PMID: 28134252) ; Zhongguo Gu Shang. 2018 Nov 25;31(11):1054-1060. (PMID: 30514049) ; Maturitas. 2016 Dec;94:149-154. (PMID: 27823736) ; Circ Res. 2017 Feb 17;120(4):713-735. (PMID: 28209797) ; Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792) ; Front Mol Neurosci. 2018 Jan 09;10:437. (PMID: 29375300) ; Biomed Pharmacother. 2019 Jan;109:2309-2317. (PMID: 30551489) ; Mol Ecol. 2017 Oct;26(20):5369-5406. (PMID: 28746784) ; Nat Genet. 2000 May;25(1):25-9. (PMID: 10802651) ; Front Neurosci. 2019 Mar 28;13:291. (PMID: 31001073) ; Sci Rep. 2016 Sep 28;6:34328. (PMID: 27677604) ; Toxicol Res. 2017 Apr;33(2):97-106. (PMID: 28443180) ; Int J Oncol. 2017 May;50(5):1739-1748. (PMID: 28393237) ; Oncol Rep. 2017 Feb;37(2):1196-1202. (PMID: 28075458) ; Nucleic Acids Res. 2017 Jan 4;45(D1):D833-D839. (PMID: 27924018) ; J Physiol. 2017 May 15;595(10):3077-3083. (PMID: 27891609) ; Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):697-712. (PMID: 30639513) ; J Appl Physiol (1985). 2018 Jul 1;125(1):49-57. (PMID: 29420160) ; Mol Med Rep. 2018 Sep;18(3):3483-3489. (PMID: 30066871) ; Bioinformatics. 2019 Oct 1;35(19):3864-3866. (PMID: 30847467) ; Eur J Immunol. 2019 Dec;49(12):2235-2244. (PMID: 31465113) ; Matrix Biol. 2018 Aug;68-69:490-506. (PMID: 29371055) ; PLoS One. 2016 Feb 03;11(2):e0148372. (PMID: 26841115) ; J Pharm Biomed Anal. 2016 May 10;123:63-73. (PMID: 26874256) ; Front Mol Neurosci. 2018 May 16;11:155. (PMID: 29867347) ; Neurotherapeutics. 2016 Oct;13(4):661-670. (PMID: 27730544) ; Curr Pharm Des. 2016;22(3):328-49. (PMID: 26561074) ; Pharmacol Rep. 2017 Aug;69(4):616-624. (PMID: 28505603) ; Curr Pharm Des. 2018 Feb 12;23(39):6071-6078. (PMID: 28619001) ; J Pharm Pharmacol. 2004 Dec;56(12):1557-62. (PMID: 15563763) ; J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5):1831-1836. (PMID: 33164475) ; Cell Biochem Biophys. 2014 Jul;69(3):523-30. (PMID: 24435883) ; Alzheimers Dement. 2021 Mar;17(3):327-406. (PMID: 33756057) ; Zhongguo Zhong Yao Za Zhi. 2005 Jan;30(2):107-10. (PMID: 15714811) ; Front Pharmacol. 2019 Mar 19;10:271. (PMID: 30941046) ; Hum Mol Genet. 2013 Apr 1;22(7):1300-15. (PMID: 23257288) ; Planta Med. 1995 Dec;61(6):523-6. (PMID: 8824946) ; Mar Drugs. 2016 Jun 28;14(7):. (PMID: 27367705) ; J Immunol. 2019 Oct 1;203(7):1753-1765. (PMID: 31462505) ; Med Oncol. 2017 Nov 09;34(12):196. (PMID: 29124478) ; Nutrients. 2018 Feb 22;10(2):. (PMID: 29470404) ; Br J Pharmacol. 2018 Nov;175(21):4137-4153. (PMID: 30051466) ; Continuum (Minneap Minn). 2020 Apr;26(2):386-414. (PMID: 32224758) ; Ann N Y Acad Sci. 2020 Feb;1462(1):118-127. (PMID: 31535723) ; Cell Transplant. 2019 Feb;28(2):145-156. (PMID: 30569751) ; Pharm Biol. 2011 Jan;49(1):78-85. (PMID: 20684747) ; Phytother Res. 2017 Jun;31(6):838-848. (PMID: 28382688) ; Pharmacol Rep. 2017 Dec;69(6):1270-1281. (PMID: 29128809) ; Sci Rep. 2019 Apr 30;9(1):6673. (PMID: 31040362) ; Neurotox Res. 2020 Aug;38(2):524-535. (PMID: 32415525) ; Int J Mol Sci. 2020 Mar 09;21(5):. (PMID: 32182911) ; J Proteomics. 2018 Jan 16;171:2-10. (PMID: 28343001) ; Front Pharmacol. 2016 Mar 15;7:52. (PMID: 27014066) ; Mol Neurobiol. 2018 Oct;55(10):8038-8050. (PMID: 29498006) ; Am J Clin Exp Immunol. 2018 Jun 05;7(3):50-56. (PMID: 30038846) ; Sci Rep. 2017 Aug 1;7(1):7002. (PMID: 28765584) ; Front Immunol. 2019 Jan 10;9:3116. (PMID: 30687321) ; EMBO Mol Med. 2018 Apr;10(4):. (PMID: 29472246) ; Breast Cancer. 2019 Nov;26(6):766-775. (PMID: 31172425) ; Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12951. (PMID: 29757466) ; Phytother Res. 2020 Jul;34(7):1556-1569. (PMID: 32022345) ; Hum Cell. 2019 Jan;32(1):22-30. (PMID: 30386989) ; Nat Commun. 2018 Mar 16;9(1):1116. (PMID: 29549264) ; Int J Mol Sci. 2017 Nov 24;18(12):. (PMID: 29186770) ; Autophagy. 2016 Dec;12(12):2516-2520. (PMID: 27715387) ; J Alzheimers Dis. 2017;57(4):1105-1121. (PMID: 28059794) ; Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243) ; Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. (PMID: 29673586) ; Front Immunol. 2020 Mar 31;11:456. (PMID: 32296418) ; Sci Rep. 2016 Jun 16;6:28089. (PMID: 27306862) ; J Neuroinflammation. 2017 Jun 9;14(1):117. (PMID: 28599652) ; Int J Mol Sci. 2018 Jun 27;19(7):. (PMID: 29954107) ; Mol Psychiatry. 2013 Apr;18(4):451-60. (PMID: 23399915) ; Front Neurosci. 2019 Feb 12;13:48. (PMID: 30809110) ; Med Sci Monit. 2020 Nov 24;26:e924699. (PMID: 33230092) ; Phytother Res. 2016 Aug;30(8):1207-18. (PMID: 27188216) ; Int Immunopharmacol. 2019 Mar;68:95-105. (PMID: 30616172) ; Biomolecules. 2019 Nov 01;9(11):. (PMID: 31683841) ; Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C135-C153. (PMID: 30379577) ; Neuron. 2019 May 22;102(4):813-827.e6. (PMID: 30982627) ; Front Aging Neurosci. 2019 Jul 31;11:184. (PMID: 31417394) ; Brain Res Bull. 2017 Apr;130:180-187. (PMID: 28161197) ; Free Radic Biol Med. 2016 Nov;100:53-65. (PMID: 27519271) ; Front Pharmacol. 2016 Jun 29;7:191. (PMID: 27445824) ; Sci Rep. 2011;1:61. (PMID: 22355580) ; J Alzheimers Dis. 2013;33 Suppl 1:S141-4. (PMID: 22710914) ; Curr Opin Neurol. 2016 Jun;29(3):340-4. (PMID: 27027554) ; Oncol Rep. 2019 Apr;41(4):2321-2328. (PMID: 30720119) ; Iran J Public Health. 2014 Jun;43(6):847-8. (PMID: 26110157) ; J Steroid Biochem Mol Biol. 2017 Jul;171:94-109. (PMID: 28263910) ; Front Cell Neurosci. 2020 Mar 19;14:51. (PMID: 32265656) ; Curr Neurol Neurosci Rep. 2019 Feb 28;19(4):18. (PMID: 30820684) ; Front Mol Neurosci. 2018 Jan 09;10:441. (PMID: 29375304) ; Cells. 2017 Nov 22;6(4):. (PMID: 29165393) ; Eur J Pharmacol. 2019 Sep 5;858:172466. (PMID: 31220437) ; Phytochemistry. 2005 Oct;66(20):2399-407. (PMID: 16137727) ; J Oleo Sci. 2016 Aug 1;65(8):693-9. (PMID: 27430387) ; Zhongguo Zhong Yao Za Zhi. 2019 Apr;44(7):1464-1474. (PMID: 31090306) ; Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):3360-3384. (PMID: 32271454) ; Neuroendocrinology. 2008;88(4):293-8. (PMID: 18679014) ; Oncol Lett. 2019 Feb;17(2):1826-1832. (PMID: 30675244) ; Int J Biol Sci. 2014 Jan 21;10(2):181-91. (PMID: 24550686) ; Front Immunol. 2018 Aug 13;9:1873. (PMID: 30150993) ; Asia Pac J Clin Oncol. 2019 Oct;15(5):e162-e166. (PMID: 30990963) ; Lancet. 2018 Oct 6;392(10154):1269-1278. (PMID: 30319114) ; J Neural Transm (Vienna). 2017 Aug;124(8):901-905. (PMID: 28150045) ; Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173) ; Chin J Nat Med. 2013 Mar;11(2):110-20. (PMID: 23787177) ; Nutrients. 2016 Sep 13;8(9):. (PMID: 27649234) ; Zhongguo Zhong Yao Za Zhi. 2018 Sep;43(17):3444-3450. (PMID: 30347910) ; Zhong Xi Yi Jie He Xue Bao. 2011 Feb;9(2):179-85. (PMID: 21288454) ; Transl Neurosci. 2018 Nov 12;9:147-153. (PMID: 30473884) ; J Ethnopharmacol. 2011 Apr 12;134(3):519-41. (PMID: 21215308) ; Mol Neurobiol. 2018 Apr;55(4):3426-3438. (PMID: 28502042) ; Neuroscience. 2015 May 21;294:193-205. (PMID: 25791226) ; Glia. 2017 Dec;65(12):1900-1913. (PMID: 28836302) ; Dose Response. 2020 Sep 14;18(3):1559325820959563. (PMID: 32973420) ; Front Pharmacol. 2020 Jan 31;10:1660. (PMID: 32082160) ; Acta Neurol Belg. 2019 Sep;119(3):359-367. (PMID: 29728903) ; Nat Cell Biol. 2016 Sep;18(9):954-966. (PMID: 27501329) ; Zhongguo Zhong Yao Za Zhi. 1990 Oct;15(10):604-6, 640. (PMID: 2268397) ; N Engl J Med. 2017 Jul 20;377(3):257-266. (PMID: 28723321) ; Semin Cell Dev Biol. 2020 Mar;99:55-64. (PMID: 29738880) ; Front Neurosci. 2019 May 15;13:472. (PMID: 31156366) ; Onco Targets Ther. 2020 Jan 10;13:299-307. (PMID: 32021276) ; Biomed Res Int. 2017;2017:7464872. (PMID: 29057264) ; Lancet Neurol. 2019 May;18(5):459-480. (PMID: 30879893) ; Life Sci. 2015 Apr 1;126:57-68. (PMID: 25634110) ; Phytomedicine. 2017 Feb 15;25:93-99. (PMID: 28190476) ; J Mol Cell Cardiol. 2018 Aug;121:36-50. (PMID: 29913136) ; Planta Med. 2000 Aug;66(6):575-7. (PMID: 10985091) ; Osteoporos Int. 2018 Mar;29(3):535-544. (PMID: 29110063) ; Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):. (PMID: 29358315) ; Pharmacol Rep. 2016 Oct;68(5):1054-9. (PMID: 27505855) ; Am J Clin Exp Immunol. 2018 Dec 20;7(6):100-105. (PMID: 30697467) ; Front Mol Neurosci. 2018 May 22;11:165. (PMID: 29872377) Contributed Indexing: Keywords: Epimedii herba; icariin; literature review; nervous system diseases; network pharmacology Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; 0 (epimedii flavone) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20210827 Date Completed: 20220113 Latest Revision: 20220113 Update Code: 20231215 PubMed Central ID: PMC8384151

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review.