Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19.
In: The Journal of infectious diseases, Jg. 224 (2021-10-28), Heft 8, S. 1362-1371
Online
academicJournal
Zugriff:
Background: To better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding and infectivity, we estimated SARS-CoV-2 RNA shedding duration, described participant characteristics associated with the first negative rRT-PCR test (resolution), and determined if replication-competent viruses was recoverable ≥10 days after symptom onset.
Methods: We collected serial nasopharyngeal specimens from 109 individuals with rRT-PCR-confirmed COVID-19 in Utah and Wisconsin. We calculated viral RNA shedding resolution probability using the Kaplan-Meier estimator and evaluated characteristics associated with shedding resolution using Cox proportional hazards regression. We attempted viral culture for 35 rRT-PCR-positive nasopharyngeal specimens collected ≥10 days after symptom onset.
Results: The likelihood of viral RNA shedding resolution at 10 days after symptom onset was approximately 3%. Time to shedding resolution was shorter among participants aged <18 years (adjusted hazards ratio [aHR], 3.01; 95% confidence interval [CI], 1.6-5.6) and longer among those aged ≥50 years (aHR, 0.50; 95% CI, .3-.9) compared to participants aged 18-49 years. No replication-competent viruses were recovered.
Conclusions: Although most patients were positive for SARS-CoV-2 for ≥10 days after symptom onset, our findings suggest that individuals with mild to moderate COVID-19 are unlikely to be infectious ≥10 days after symptom onset.
(Published by Oxford University Press for the Infectious Diseases Society of America 2021.)
| Titel: |
Persistent SARS-CoV-2 RNA Shedding Without Evidence of Infectiousness: A Cohort Study of Individuals With COVID-19.
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| Autor/in / Beteiligte Person: | Owusu, D ; Pomeroy, MA ; Lewis, NM ; Wadhwa, A ; Yousaf, AR ; Whitaker, B ; Dietrich, E ; Hall, AJ ; Chu, V ; Thornburg, N ; Christensen, K ; Kiphibane, T ; Willardson, S ; Westergaard, R ; Dasu, T ; Pray, IW ; Bhattacharyya, S ; Dunn, A ; Tate, JE ; Kirking, HL ; Matanock, A |
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| Zeitschrift: | The Journal of infectious diseases, Jg. 224 (2021-10-28), Heft 8, S. 1362-1371 |
| Veröffentlichung: | Jan. 2011- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1904-2010 : Chicago, IL : University of Chicago Press, 2021 |
| Medientyp: | academicJournal |
| ISSN: | 1537-6613 (electronic) |
| DOI: | 10.1093/infdis/jiab107 |
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