Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana.
In: Microbial pathogenesis, Jg. 153 (2021-04-01), S. 104797
Online
academicJournal
Zugriff:
Bartonella quintana is a facultative intracellular bacterium responsible for relapsing fever, an example of non-sterilizing immunity. The cellular sanctuary of B. quintana in-between febrile relapses remains unknown but repeated detection of B. quintana in dental pulp specimens suggested long-term half-life dental pulp stem cells (DPSCs) as candidates. As the capacity of DPSCs to internalize microscopic particles was unknown, we confirmed that DPSCs internalized B. quintana bacteria: Gimenez staining and fluorescence microscopy localized B. quintana bacteria inside DPSCs and this internalization did not affect the cellular multiplication of DPSCs during a one-month follow-up despite the increase in the bacterial load. B. quintana-infected DPSCs did not produce Tumor Necrosis Factor-α whereas an important production of Monocytes Chemoattractant Protein-1 was observed. These unprecedented observations suggest the possibility that DPSCs are shelters for the long-term persistence of B. quintana in the host, warranting further experimental and clinical investigations.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
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Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana.
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Autor/in / Beteiligte Person: | Oumarou Hama, H ; Hamada, A ; Aboudharam, G ; Ghigo, É ; Drancourt, M |
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Zeitschrift: | Microbial pathogenesis, Jg. 153 (2021-04-01), S. 104797 |
Veröffentlichung: | London ; Orlando : Academic Press, c1986-, 2021 |
Medientyp: | academicJournal |
ISSN: | 1096-1208 (electronic) |
DOI: | 10.1016/j.micpath.2021.104797 |
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