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A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.

Medchalmi, S ; Tare, P ; et al.
In: The FEBS journal, Jg. 288 (2021-08-01), Heft 15, S. 4576-4595
Online academicJournal

Titel:
A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.
Autor/in / Beteiligte Person: Medchalmi, S ; Tare, P ; Sayyad, Z ; Swarup, G
Link:
Zeitschrift: The FEBS journal, Jg. 288 (2021-08-01), Heft 15, S. 4576-4595
Veröffentlichung: Oxford, UK : Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, c2005-, 2021
Medientyp: academicJournal
ISSN: 1742-4658 (electronic)
DOI: 10.1111/febs.15752
Schlagwort:
  • Autophagy
  • Autophagy-Related Protein 5 metabolism
  • Cell Cycle Proteins metabolism
  • Endoplasmic Reticulum Stress
  • HEK293 Cells
  • Humans
  • Membrane Transport Proteins metabolism
  • Microtubule-Associated Proteins metabolism
  • Protein Binding
  • Transcription Factor CHOP metabolism
  • Amyotrophic Lateral Sclerosis genetics
  • Apoptosis
  • Cell Cycle Proteins genetics
  • Glaucoma genetics
  • Membrane Transport Proteins genetics
  • Mutation
  • Neurons metabolism
  • Protein Serine-Threonine Kinases metabolism
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article; Research Support, Non-U.S. Gov't
  • Language: English
  • [FEBS J] 2021 Aug; Vol. 288 (15), pp. 4576-4595. <i>Date of Electronic Publication: </i>2021 Feb 19.
  • MeSH Terms: Apoptosis* ; Mutation* ; Amyotrophic Lateral Sclerosis / *genetics ; Cell Cycle Proteins / *genetics ; Glaucoma / *genetics ; Membrane Transport Proteins / *genetics ; Neurons / *metabolism ; Protein Serine-Threonine Kinases / *metabolism ; Autophagy ; Autophagy-Related Protein 5 / metabolism ; Cell Cycle Proteins / metabolism ; Endoplasmic Reticulum Stress ; HEK293 Cells ; Humans ; Membrane Transport Proteins / metabolism ; Microtubule-Associated Proteins / metabolism ; Protein Binding ; Transcription Factor CHOP / metabolism
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  • Contributed Indexing: Keywords: ER stress; Tbk1; amyotrophic lateral sclerosis; glaucoma; optineurin
  • Substance Nomenclature: 0 (ATG5 protein, human) ; 0 (Autophagy-Related Protein 5) ; 0 (Cell Cycle Proteins) ; 0 (DDIT3 protein, human) ; 0 (MAP1LC3B protein, human) ; 0 (Membrane Transport Proteins) ; 0 (Microtubule-Associated Proteins) ; 0 (OPTN protein, human) ; 147336-12-7 (Transcription Factor CHOP) ; EC 2.7.11.1 (Protein Serine-Threonine Kinases) ; EC 2.7.11.1 (TBK1 protein, human)
  • Entry Date(s): Date Created: 20210206 Date Completed: 20210826 Latest Revision: 20211204
  • Update Code: 20231215

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