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Introduction: the emergence of extended-spectrum beta-lactamase-producing Entero bacteriaceae (E-ESBLs) is currently a major public health problem in the world and, in particular, in developing countries. In Cameroon, data on E-ESBLs are rare, especially in Garoua and in the northern region of the country. The objective of this study is to document the epidemiology of E-ESBL infections in small children and to explore their associations with possible risk factors.

Methods: this was a cross-sectional, descriptive study conducted from June 14 to September 30, 2018, including small children with suspected urinary tract infections (UTI) attending the outpatient pediatric departments of two health facilities in the city of Garoua. Urine samples were analyzed at the Bacteriology Laboratory of the Pasteur Center of Cameroon, Annex Garoua. Bacterial culture was carried out on Bio-Rad UriSelect® chromogenic agar and the identification was confirmed by bioMérieux API 20E. The antibiotic susceptibility was determined using the bioMérieux ATB UR gallery and the ESBL phenotype was detected by the double disk synergy method according to the CA-SFM 2013 recommendations. The data was analyzed with the R Statistical Software version 2.15.2.

Results: a total of 57 urine samples were collected from children aged from one month to two years, 37 boys and 20 girls. Bacteria were detected by culture in 20 samples: Escherichia coliwas the most frequently (75 %) isolated species followed by Klebsiella pneumoniae(25%). More than half of the infected samples (55%) contained E-ESBL. The presence of an ESBL was significantly associated with previous antibiotic intake up to 3 months prior current UTI (p=0.01664). The E-ESBL strains showed co-resistance to different antibiotics.

Conclusion: this study reveals the important dissemination of E-ESBLs among small children in the community and a high rate of co-resistance to the different antibiotic families commonly used.

Competing Interests: The authors declare no competing interests.

(Copyright: Karyom Djim-Adjim-Ngana et al.)

Titel:	Prevalence of extended-spectrum beta-lactamase-producing enterobacterial urinary infections and associated risk factors in small children of Garoua, Northern Cameroon.
Autor/in / Beteiligte Person:	Djim-Adjim-Ngana, K ; Oumar, LA ; Mbiakop, BW ; Njifon, HLM ; Crucitti, T ; Nchiwan, EN ; Yanou, NN ; Deweerdt, L
Link:	Zum Volltext
Zeitschrift:	The Pan African medical journal, Jg. 36 (2020-07-06), S. 157
Veröffentlichung:	Kampala, Uganda : African Field Epidemiology Network, 2020
Medientyp:	academicJournal
ISSN:	1937-8688 (electronic)
DOI:	10.11604/pamj.2020.36.157.21347
Schlagwort:	Age Factors Age of Onset Anti-Bacterial Agents therapeutic use Cameroon epidemiology Child, Preschool Cross-Sectional Studies Drug Resistance, Multiple, Bacterial genetics Enterobacteriaceae Infections drug therapy Enterobacteriaceae Infections urine Female Humans Infant Male Microbial Sensitivity Tests Prevalence Risk Factors Urinalysis Urinary Tract Infections drug therapy Urinary Tract Infections urine beta-Lactamases genetics Enterobacteriaceae Infections epidemiology Urinary Tract Infections epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pan Afr Med J] 2020 Jul 06; Vol. 36, pp. 157. <i>Date of Electronic Publication: </i>2020 Jul 06 (<i>Print Publication: </i>2020). MeSH Terms: Enterobacteriaceae Infections / epidemiology ; Urinary Tract Infections / epidemiology ; Age Factors ; Age of Onset ; Anti-Bacterial Agents / therapeutic use ; Cameroon / epidemiology ; Child, Preschool ; Cross-Sectional Studies ; Drug Resistance, Multiple, Bacterial / genetics ; Enterobacteriaceae Infections / drug therapy ; Enterobacteriaceae Infections / urine ; Female ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Prevalence ; Risk Factors ; Urinalysis ; Urinary Tract Infections / drug therapy ; Urinary Tract Infections / urine ; beta-Lactamases / genetics References: BMC Infect Dis. 2012 Mar 09;12:53. (PMID: 22405322) ; J Clin Microbiol. 2005 Jul;43(7):3273-7. (PMID: 16000447) ; Clin Infect Dis. 2011 Oct;53(7):677-85. (PMID: 21890771) ; J Antimicrob Chemother. 2005 Sep;56(3):463-9. (PMID: 16020539) ; Pan Afr Med J. 2017 Sep 13;28:29. (PMID: 29138665) ; Rev Infect Dis. 1988 Jul-Aug;10(4):867-78. (PMID: 3263690) ; AMA Arch Intern Med. 1957 Nov;100(5):709-14. (PMID: 13468815) ; Med Mal Infect. 2007 Nov;37(11):746-52. (PMID: 17434702) ; Prog Urol. 2012 Jan;22(1):17-21. (PMID: 22196001) ; Pediatrics. 2016 Apr;137(4):. (PMID: 26969273) Contributed Indexing: Keywords: Urinary infection; antibiotics; enterobacteria; synergy test Substance Nomenclature: 0 (Anti-Bacterial Agents) ; EC 3.5.2.6 (beta-Lactamases) Entry Date(s): Date Created: 20200903 Date Completed: 20201222 Latest Revision: 20220416 Update Code: 20240513 PubMed Central ID: PMC7436643

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Prevalence of extended-spectrum beta-lactamase-producing enterobacterial urinary infections and associated risk factors in small children of Garoua, Northern Cameroon.