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Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property.

Wang, M ; Rong, Y ; et al.
In: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, Jg. 37 (2021), Heft 1, S. 39-46
Online academicJournal

Titel:
Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property.
Autor/in / Beteiligte Person: Wang, M ; Rong, Y ; Luo, L
Link:
Zeitschrift: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, Jg. 37 (2021), Heft 1, S. 39-46
Veröffentlichung: Berlin : Springer International, c1985-, 2021
Medientyp: academicJournal
ISSN: 1433-0350 (electronic)
DOI: 10.1007/s00381-020-04690-8
Schlagwort:
  • Animals
  • Animals, Newborn
  • Apoptosis
  • Brain
  • Female
  • Flavonoids
  • Mice
  • Pregnancy
  • Hypoxia-Ischemia, Brain drug therapy
  • Neuroprotective Agents pharmacology
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article
  • Language: English
  • [Childs Nerv Syst] 2021 Jan; Vol. 37 (1), pp. 39-46. <i>Date of Electronic Publication: </i>2020 Jul 15.
  • MeSH Terms: Hypoxia-Ischemia, Brain* / drug therapy ; Neuroprotective Agents* / pharmacology ; Animals ; Animals, Newborn ; Apoptosis ; Brain ; Female ; Flavonoids ; Mice ; Pregnancy
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(PMID: 723562910.1002/ana.410090206) ; Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM (2003) Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke 34(1):207–213. (PMID: 12511776226209810.1161/01.STR.0000047101.87575.3C) ; Zhao H, Sapolsky RM (2006) Steinberg GK. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34(3):249–270. (PMID: 1730835610.1385/MN:34:3:249) ; Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC (2010) Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway. Eur J Pharmacol 642(1–3):146–153. (PMID: 2051913810.1016/j.ejphar.2010.05.012) ; Jin J, Wang H, Hua X, Chen D, Huang C, Chen Z (2019) An outline for thepharmacological effect of icariin in the nervous system. Eur J Pharmacol 842:20–32. 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(PMID: 2652045210.1007/s12035-015-9488-4) ; Xiao AJ, Chen W, Xu B, Liu R, Turlova E, Barszczyk A, Sun CL, Liu L, Deurloo M, Wang GL (2014) Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury. Mar Drugs 13(1):29–47. (PMID: 25546517430692310.3390/md13010029) ; Hagberg H, Mallard C, Rousset CI (2009) Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol 24(9):1141–1146. (PMID: 19574577367455210.1177/0883073809338212) ; Song YH, Cai H, Gu N, Qian CF, Cao SP, Zhao ZM (2011) Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure. J Pharm Pharmacol 63(4):541–549. (PMID: 2140160610.1111/j.2042-7158.2010.01241.x) ; Li L, Wang XM (2008) Progress of pharmacological research on icariin. Zhongguo Zhong Yao Za Zhi 33(23):2727–2732. 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(PMID: 2579122610.1016/j.neuroscience.2015.02.053) ; Liu XM, Feng Y, Li AM (2015) Efect of G-CSF and TPO on HIBD in neonatal rats. Asian Pac J Trop Med 8:132–136. (PMID: 2590202710.1016/S1995-7645(14)60303-5) ; Jin F, Gong QH, Xu YS, Wang LN, Jin H, Li F, Li LS, Ma YM, Shi JS (2014) Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling. Int J Neuropsychopharmacol 17(6):871–881. (PMID: 2451308310.1017/S1461145713001533) ; Chen WF, Wu L, Du ZR, Chen L, Xu AL, Chen XH, Teng JJ, Wong MS (2017) Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: involvement of PI3K/Akt and MEK/ERK signaling pathways. Phytomedicine 25:93–99. (PMID: 2819047610.1016/j.phymed.2016.12.017) ; Zhu HR, Wang ZY, Zhu XL, Wu XX, Li EG, Xu Y (2010) Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke. Neuropharmacology 59(1–2):70–76. (PMID: 2038150410.1016/j.neuropharm.2010.03.017) ; Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y (2009) Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol 609(1–3):40–44. (PMID: 1930387010.1016/j.ejphar.2009.03.033) ; Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, Turlova E, Barszczyk A, Zhong X, Sun CL, Britto LR, Feng ZP, Sun HS (2015) TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. Mol Brain 8:11. (PMID: 25761704433720110.1186/s13041-015-0102-5) ; Kilicdag H, Daglioglu YK, Erdogan S, Zorludemir S (2014) Effects of caffeine on neuronal apoptosis in neonatal hypoxic-ischemic brain injury. J Matern Fetal Neonatal Med 27(14):1470–1475. (PMID: 2439282310.3109/14767058.2013.878694) ; Sidhu RS, Tuor UI, Del Bigio MR (1997) Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats. Neurosci Lett 223(2):129–132. (PMID: 908969010.1016/S0304-3940(97)13426-7)
  • Contributed Indexing: Keywords: Apoptosis; Hypoxic-ischemic brain damage; Icariin; Neuroprotection
  • Substance Nomenclature: 0 (Flavonoids) ; 0 (Neuroprotective Agents) ; VNM47R2QSQ (icariin)
  • Entry Date(s): Date Created: 20200717 Date Completed: 20210624 Latest Revision: 20220720
  • Update Code: 20240513

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