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Background: Osteochondral defects caused by an acute traumatic injury or articular degeneration remains difficult to be manipulated. Repair of articular defects is still a great challenge for both tissue engineers and orthopedic surgeons. Therefore, combination of biomaterials with cartilage promotive drugs is well worth being developed to support the regeneration of both cartilage and subchondral bone.

Methods: Rabbits undergoing osteochondral defect surgery were intrarticularly injected with icariin-conditioned serum (ICS), chitosan (CSSH) and combination of ICS with CSSH, respectively. Gait analysis was performed using VICON motion capture system. ICRS score and immunohistochemical (IHC) analysis including H&E, Safranin O, toluidine blue and collagen II staining was employed to evaluate macroscopic cartilage regeneration and determine the morphologic repair of cartilage.

Results: Rabbits with the treatment of ICS or CSSH alone showed mild improvement in hopping time and range of joint angles while ICS-CSSH group exhibited longer jumping time and larger range of joint angles. In addition, femoral condyle in ICS-CSSH rabbits could be seen with more native cartilage and subchondral bone regeneration in both macroscopic observation and IHC analysis.

Conclusion: ICS combined with CSSH could promote the repair of osteochondral defect in rabbit knees. Combination of biomaterials with cartilage promotive drugs may ultimately have profound implications in the management of cartilage defect.

Titel:	Repair of osteochondral defect using icariin-conditioned serum combined with chitosan in rabbit knees.
Autor/in / Beteiligte Person:	Zhang, J ; Ming, D ; Ji, Q ; Liu, A ; Zhang, C ; Jiao, J ; Shang, M
Link:	Zum Volltext
Zeitschrift:	BMC complementary medicine and therapies, Jg. 20 (2020-06-22), Heft 1, S. 193
Veröffentlichung:	London : BioMed Central, [2020]-, 2020
Medientyp:	academicJournal
ISSN:	2662-7671 (electronic)
DOI:	10.1186/s12906-020-02996-3
Schlagwort:	Animals Biocompatible Materials pharmacology Cartilage, Articular injuries Cell Line China Disease Models, Animal Drug Therapy, Combination Male Mice Rabbits Range of Motion, Articular Serum Tissue Engineering Cartilage, Articular drug effects Chitosan pharmacology Culture Media, Conditioned pharmacology Flavonoids pharmacology Knee Injuries drug therapy Wound Healing drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Complement Med Ther] 2020 Jun 22; Vol. 20 (1), pp. 193. <i>Date of Electronic Publication: </i>2020 Jun 22. MeSH Terms: Cartilage, Articular / drug effects ; Chitosan / pharmacology ; Culture Media, Conditioned / pharmacology ; Flavonoids / pharmacology ; Knee Injuries / drug therapy ; Wound Healing / drug effects ; Animals ; Biocompatible Materials / pharmacology ; Cartilage, Articular / injuries ; Cell Line ; China ; Disease Models, Animal ; Drug Therapy, Combination ; Male ; Mice ; Rabbits ; Range of Motion, Articular ; Serum ; Tissue Engineering Comments: Erratum in: BMC Complement Med Ther. 2022 Dec 22;22(1):336. (PMID: 36550582) References: J Biomater Sci Polym Ed. 2019 Jun;30(8):662-678. (PMID: 30947639) ; Pharmazie. 2007 May;62(5):388-91. (PMID: 17557750) ; Arthrosc Tech. 2019 Apr 09;8(4):e413-e418. (PMID: 31110940) ; Osteoarthritis Cartilage. 2010 Jul;18(7):971-80. (PMID: 20433936) ; Phytomedicine. 2011 Jan 15;18(2-3):176-85. (PMID: 20554188) ; Biomed Pharmacother. 2018 Aug;104:652-660. (PMID: 29803179) ; Macromol Biosci. 2017 May;17(5):. (PMID: 27892651) ; Tissue Eng Part B Rev. 2010 Feb;16(1):105-15. (PMID: 19831641) ; Biomed Pharmacother. 2016 Dec;84:931-939. (PMID: 27764755) ; Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(23):3219-22. (PMID: 21355254) ; Biomed Pharmacother. 2017 Jul;91:581-589. (PMID: 28486190) ; J Pharm Biomed Anal. 2007 Nov 30;45(4):667-72. (PMID: 17706393) ; Osteoarthritis Cartilage. 2009 Feb;17(2):152-60. (PMID: 18674932) ; Biomacromolecules. 2016 Jun 13;17(6):2178-88. (PMID: 27194446) ; PLoS One. 2015 Dec 28;10(12):e0145551. (PMID: 26709697) ; J Tissue Eng Regen Med. 2011 Aug;5(8):e188-96. (PMID: 21394931) ; Knee. 2020 Jan;27(1):18-25. (PMID: 31883860) ; Inflamm Res. 2003 Oct;52(10):404-7. (PMID: 14520515) ; PLoS One. 2016 Feb 03;11(2):e0148372. (PMID: 26841115) ; Cell Transplant. 2017 Mar 13;26(3):417-427. (PMID: 27737727) ; Biomaterials. 2013 Dec;34(36):9103-14. (PMID: 24008040) ; Int J Periodontics Restorative Dent. 2002 Dec;22(6):547-57. (PMID: 12516826) ; J Ethnopharmacol. 2008 Jul 23;118(2):271-9. (PMID: 18501540) ; Curr Med Chem. 2020;27(28):4584-4592. (PMID: 31985365) ; Biomaterials. 2016 Nov;108:157-67. (PMID: 27636153) ; Front Pharmacol. 2019 Jun 28;10:699. (PMID: 31316380) ; Osteoarthritis Cartilage. 2012 Jun;20(6):476-85. (PMID: 22353747) ; Pharmazie. 2005 Feb;60(2):120-5. (PMID: 15739900) ; Stomatologiia (Mosk). 2019;98(6. Vyp. 2):12-18. (PMID: 31957416) ; Br Med Bull. 2013;105:169-84. (PMID: 22763153) ; Int J Biol Macromol. 2017 Nov;104(Pt B):1936-1945. (PMID: 28359897) ; Biomed Microdevices. 2019 Mar 25;21(2):34. (PMID: 30906951) ; Am J Vet Res. 2007 Mar;68(3):290-6. (PMID: 17331019) ; BMC Complement Altern Med. 2019 Jul 3;19(1):155. (PMID: 31269947) ; Stem Cells Int. 2019 Dec 19;2019:1515040. (PMID: 31949434) ; J Tissue Eng Regen Med. 2019 Apr;13(4):599-611. (PMID: 30706995) ; Biomed Mater. 2012 Apr;7(2):024109. (PMID: 22455987) Grant Information: 51573137 National Natural Science Foundation of China; 81102607 National Natural Science Foundation of China Contributed Indexing: Keywords: Cartilage defect; Chitosan; Chondrocyte; Icarrin Substance Nomenclature: 0 (Biocompatible Materials) ; 0 (Culture Media, Conditioned) ; 0 (Flavonoids) ; 9012-76-4 (Chitosan) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20200624 Date Completed: 20201204 Latest Revision: 20240329 Update Code: 20240329 PubMed Central ID: PMC7310103

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Repair of osteochondral defect using icariin-conditioned serum combined with chitosan in rabbit knees.