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Objectives: Low and high birth weight is associated with higher levels of cardiometabolic risk factors and adiposity in children and adolescents, and increases the risk of cardiovascular diseases, obesity, and early mortality later in life. Moderate-to-vigorous physical activity (MVPA) is associated with lower cardiometabolic risk factors and may mitigate the detrimental consequences of high or low birth weight. Thus, we examined whether MVPA modified the associations between birth weight and cardiometabolic risk factors in children and adolescents.

Methods: We used pooled individual data from 12 cohort- or cross-sectional studies including 9,100 children and adolescents. Birth weight was measured at birth or maternally reported retrospectively. Device-measured physical activity (PA) and cardiometabolic risk factors were measured in childhood or adolescence. We tested for associations between birth weight, MVPA, and cardiometabolic risk factors using multilevel linear regression, including study as a random factor. We tested for interaction between birth weight and MVPA by introducing the interaction term in the models (birth weight x MVPA).

Results: Most of the associations between birth weight (kg) and cardiometabolic risk factors were not modified by MVPA (min/day), except between birth weight and waist circumference (cm) in children (p = 0.005) and HDL-cholesterol (mmol/l) in adolescents (p = 0.040). Sensitivity analyses suggested that some of the associations were modified by VPA, i.e., the associations between birth weight and diastolic blood pressure (mmHg) in children (p = 0.009) and LDL- cholesterol (mmol/l) (p = 0.009) and triglycerides (mmol/l) in adolescents (p = 0.028).

Conclusion: MVPA appears not to consistently modify the associations between low birth weight and cardiometabolic risk. In contrast, MVPA may mitigate the association between higher birth weight and higher waist circumference in children. MVPA is consistently associated with a lower cardiometabolic risk across the birth weight spectrum. Optimal prenatal growth and subsequent PA are both important in relation to cardiometabolic health in children and adolescents.

Titel:	Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies.
Autor/in / Beteiligte Person:	Bernhardsen, GP ; Stensrud, T ; Hansen, BH ; Steene-Johannesen, J ; Kolle, E ; Nystad, W ; Anderssen, SA ; Hallal, PC ; Janz, KF ; Kriemler, S ; Andersen, LB ; Northstone, K ; Resaland, GK ; Sardinha, LB ; van Sluijs EMF ; Ried-Larsen, M ; Ekelund, U
Link:	Zum Volltext
Zeitschrift:	International journal of obesity (2005), Jg. 44 (2020-10-01), Heft 10, S. 2052
Veröffentlichung:	London : Nature Pub. Group, c2005-, 2020
Medientyp:	academicJournal
ISSN:	1476-5497 (electronic)
DOI:	10.1038/s41366-020-0612-9
Schlagwort:	Adiposity Adolescent Blood Pressure Child Cholesterol, HDL blood Humans Norway Triglycerides blood Waist Circumference Birth Weight Cardiometabolic Risk Factors Exercise
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: International Children’s Accelerometry Database (ICAD) Collaborators Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Int J Obes (Lond)] 2020 Oct; Vol. 44 (10), pp. 2052-2063. <i>Date of Electronic Publication: </i>2020 Jun 03. MeSH Terms: Birth Weight* ; Cardiometabolic Risk Factors* ; Exercise* ; Adiposity ; Adolescent ; Blood Pressure ; Child ; Cholesterol, HDL / blood ; Humans ; Norway ; Triglycerides / blood ; Waist Circumference References: Gluckman PD, Hanson MA. The developmental origins of health and disease: an overview. In: Gluckman P, Hanson M, editors. Developmental origins of health and disease. Cambridge: Cambridge University Press; 2006. p. 1-5. ; Risnes KR, Vatten LJ, Baker JL, Jameson K, Sovio U, Kajantie E, et al. Birthweight and mortality in adulthood: a systematic review and meta-analysis. 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(PMID: 206316433130563) Grant Information: MC_UU_12015/7 United Kingdom MRC_ Medical Research Council; MC_UU_00006/5 United Kingdom MRC_ Medical Research Council; MC_PC_15018 United Kingdom MRC_ Medical Research Council; MC_UU_00006/4 United Kingdom MRC_ Medical Research Council; G0701877 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; R01 DK077659 United States DK NIDDK NIH HHS; MR/K023187/1 United Kingdom MRC_ Medical Research Council; R01 HL071248 United States HL NHLBI NIH HHS; MC_UU_12015/3 United Kingdom MRC_ Medical Research Council; MC_PC_19009 United Kingdom MRC_ Medical Research Council Substance Nomenclature: 0 (Cholesterol, HDL) ; 0 (Triglycerides) Entry Date(s): Date Created: 20200605 Date Completed: 20211115 Latest Revision: 20220131 Update Code: 20240513 PubMed Central ID: PMC7508671

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Birth weight, cardiometabolic risk factors and effect modification of physical activity in children and adolescents: pooled data from 12 international studies.