Gender-specific effect of urate on white matter integrity in Parkinson's disease.
In: Parkinsonism & related disorders, Jg. 75 (2020-06-01), S. 41
Online
academicJournal
Zugriff:
Objectives: To investigate the potential protective influence of serum uric acid (UA) level on white matter (WM) microstructural changes in de novo Parkinson's disease (PD).
Methods: We enrolled a total of 184 patients with drug-naïve de novo PD and 59 age and gender-matched controls that underwent diffusion tensor imaging (DTI). Based on the distribution, serum UA levels were stratified into tertiles in PD patients by gender. Using tract-based spatial statistics (TBSS) analysis, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were used to compare WM integrity between the groups.
Results: Interaction analysis showed that interaction effect on FA values between gender and UA levels in PD was significant in widespread WM areas, including frontal-parieto-temporal, corpus callosum, bilateral internal and external capsule, and thalamic regions. Multiple regression analysis revealed that FA values had a significantly positive correlation with UA levels across widespread WM areas in male patients. However, there was no significant correlation between DTI measures and UA levels in female patients. In a group comparison in male patients, PD with the lowest UA level (PD-L-UA) group showed significantly lower FA and higher MD and RD values in frontal-parieto-temporal WM regions than PD with the highest UA level (PD-H-UA) group. However, female patients did not show significant difference of DTI measures between PD-L-UA and PD-H-UA groups.
Conclusions: The present study demonstrated that the serum UA levels may have the potentially gender-specific close relationship with WM integrity in the early stage of PD.
Competing Interests: Declaration of competing interest None.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Titel: |
Gender-specific effect of urate on white matter integrity in Parkinson's disease.
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Autor/in / Beteiligte Person: | Lee, YH ; Chung, SJ ; Yoo, HS ; Lee, Y ; Sohn, YH ; Cha, J ; Lee, PH |
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Zeitschrift: | Parkinsonism & related disorders, Jg. 75 (2020-06-01), S. 41 |
Veröffentlichung: | Kidlington, Oxford, U.K. ; Tarrytown, NY : Elsevier Science, c1995-, 2020 |
Medientyp: | academicJournal |
ISSN: | 1873-5126 (electronic) |
DOI: | 10.1016/j.parkreldis.2020.05.012 |
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