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BACKGROUND Osteoporotic fractures are common in postmenopausal women and associated with complications. Numerous studies have demonstrated that icariin can be used to treat fractures and osteoporosis. Herein, we evaluated the efficacy of gavage-administered icariin to promote fracture healing in postmenopausal osteoporotic fracture (POF) rats. MATERIAL AND METHODS In this study, ovariectomy-induced POF rats were treated with 600 mg/kg icariin. Micro-computed tomography (micro-CT) was used to assess fracture healing; besides, serum APK, TRACP-5b, and E₂ expression levels were detected by commercial kits, and the uterine index was calculated. In addition, the expression of osteogenesis-related proteins (Runx 2 and COL1A2) in the callus was measured by western blot, whereas the expression of OPG/RANKL pathway proteins was measured by western blot and immunohistochemical analysis. RESULTS Our data revealed that icariin promoted the expression level of Runx 2 and COL1A2 and suppressed the expression level of serum bone turn over biomarkers via the OPG/RANKL pathway. Besides, a more mature callus was observed in the POF rats receiving icariin than in the untreated POF rats, while serum E₂ and uterine index were unaffected by icariin treatment. CONCLUSIONS These results revealed that icariin could promote fracture healing in ovariectomized rats via OPG/RANKL signaling, and that serum E₂ and uterine index were not affected by icariin treatment.

Titel:	Icariin Promotes Fracture Healing in Ovariectomized Rats.
Autor/in / Beteiligte Person:	Zhang, Y ; Han, B ; Wei, Y ; Jing, J ; Li, J
Link:	Zum Volltext
Zeitschrift:	Medical science monitor : international medical journal of experimental and clinical research, Jg. 26 (2020-04-28), S. e924554
Veröffentlichung:	2014- : Smithtown, NY : International Scientific Information, Inc. ; <i>Original Publication</i>: Warsaw, Poland : Medical Science International, 2020
Medientyp:	academicJournal
ISSN:	1643-3750 (electronic)
DOI:	10.12659/MSM.924554
Schlagwort:	Animals Bone Density drug effects Bone and Bones metabolism China Female Fracture Healing drug effects Fracture Healing physiology Osteoporotic Fractures drug therapy Osteoprotegerin metabolism Ovariectomy methods RANK Ligand metabolism Rats Rats, Sprague-Dawley X-Ray Microtomography methods Flavonoids pharmacology Fractures, Bone drug therapy Osteoporosis drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Med Sci Monit] 2020 Apr 28; Vol. 26, pp. e924554. <i>Date of Electronic Publication: </i>2020 Apr 28. MeSH Terms: Flavonoids / pharmacology ; Fractures, Bone / drug therapy ; Osteoporosis / *drug therapy ; Animals ; Bone Density / drug effects ; Bone and Bones / metabolism ; China ; Female ; Fracture Healing / drug effects ; Fracture Healing / physiology ; Osteoporotic Fractures / drug therapy ; Osteoprotegerin / metabolism ; Ovariectomy / methods ; RANK Ligand / metabolism ; Rats ; Rats, Sprague-Dawley ; X-Ray Microtomography / methods References: JAMA. 2009 Feb 4;301(5):513-21. (PMID: 19190316) ; Bone. 2001 Jan;28(1):80-6. (PMID: 11165946) ; Int Immunopharmacol. 2018 Sep;62:277-286. (PMID: 30036771) ; Bone. 2015 Oct;79:94-104. (PMID: 26036172) ; Obstet Gynecol. 2001 Jan;97(1):97-100. (PMID: 11152916) ; J Cell Biochem. 2017 May;118(5):962-966. (PMID: 27862210) ; Environ Pollut. 2019 Jun;249:620-628. (PMID: 30933759) ; Lancet. 2011 Apr 9;377(9773):1276-87. (PMID: 21450337) ; Am J Hum Biol. 2019 May;31(3):e23240. (PMID: 30897260) ; Osteoporos Int. 2018 Mar;29(3):535-544. (PMID: 29110063) ; J Bone Miner Res. 2013 Jul;28(7):1641-52. (PMID: 23427056) ; Biochem Biophys Res Commun. 2009 Jul 10;384(4):501-5. (PMID: 19426706) ; Stem Cell Reports. 2015 Feb 10;4(2):190-8. (PMID: 25680477) ; J Cell Physiol. 2013 Mar;228(3):513-21. (PMID: 22777826) ; Rheum Dis Clin North Am. 2007 Feb;33(1):149-76. (PMID: 17367698) ; Nurse Pract. 2009 Jun;34(6):30-40; quiz 41. (PMID: 19474629) ; Bone. 2006 Jun;38(6):818-25. (PMID: 16413840) ; Phytomedicine. 2009 Apr;16(4):320-6. (PMID: 19269147) ; Lancet. 2002 May 18;359(9319):1761-7. (PMID: 12049882) ; J Biol Chem. 2010 Aug 13;285(33):25354-62. (PMID: 20547482) ; J Bone Miner Res. 2007 Jul;22(7):1072-9. (PMID: 17419678) ; Osteoporos Int. 2017 Oct;28(10):3043-3053. (PMID: 28808745) ; Genet Mol Res. 2015 Aug 10;14(3):9215-24. (PMID: 26345854) ; Biochem Biophys Res Commun. 2019 Jan 15;508(3):902-906. (PMID: 30538045) ; Protein Expr Purif. 2000 Oct;20(1):48-57. (PMID: 11035950) ; Nature. 2017 Oct 4;550(7674):S15-S17. (PMID: 28976955) ; Molecules. 2014 Nov 14;19(11):18690-704. (PMID: 25405287) ; J Bone Miner Res. 2000 Jan;15(1):2-12. (PMID: 10646108) ; J Cell Biochem. 2019 Aug;120(8):12402-12411. (PMID: 30825231) ; J Bone Miner Metab. 2018 Mar;36(2):180-188. (PMID: 28681147) ; Dig Liver Dis. 2012 Oct;44(10):849-54. (PMID: 22658643) Substance Nomenclature: 0 (Flavonoids) ; 0 (Osteoprotegerin) ; 0 (RANK Ligand) ; 0 (Tnfrsf11b protein, rat) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20200429 Date Completed: 20210104 Latest Revision: 20231113 Update Code: 20231215 PubMed Central ID: PMC7201894

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Icariin Promotes Fracture Healing in Ovariectomized Rats.