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Background: Thin endometrium, defined as <7 mm of the endometrial thickness around ovulation period, had been identified as a negative factor on pregnancy rate of infertile women. It was considered to be the toughest part in treatment of infertility, because there was a lack of significant effect, although many drugs had been already used. Icariin was one of the major bioactive pharmaceutical constituent extracted from the Chinese herb "Ying Yang Huo," in the genus of Epimedium, and some randomized controlled trials reported its application for thin endometrium. There is no systematic review focusing on the effective of icariin in treating infertile women with thin endometrium, so our review aims to explore it.

Methods: The bibliographic database and electronic library will be systematically searched online, such as MEDLINE, EMBASE, Web of Science, Clinicaltrails.org., China National Knowledge Infrastructure Database (CNKI), Wan fang Database, China Biology Medicine Database (CBM), VIP Science Technology Periodical Database, and Cochrane Library. And the reference listed for potential literatures of included studies will be scanned additionally. Related randomized controlled trials (RCTs) will be collected and selected before January 4, 2020. Trials will be screened by independent reviewers, and the literature will be search in English or Chinese, with the search terms as "Icariin," "Epimedium," "infertile women," "female infertility," "endometrium," "pregnancy rate." The software for Systematic review and Meta-analysis is RevMan 5.3. The protocol and the systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement.

Result and Conclusion: The efficacy of icariin to treat thin endometrium will be evaluated, and the conclusion will be published to help clinicians determine treatment strategy for infertile women with thin endometirum by providing medical evidence.

Registration Information: PROSPERO CRD42019148977.

Titel:	The effect of icariin for infertile women with thin endometrium: A protocol for systematic review.
Autor/in / Beteiligte Person:	Du, J ; Lu, H ; Yu, X ; Dong, L ; Mi, L ; Wang, J ; Zheng, X ; Feng, K
Link:	Zum Volltext
Zeitschrift:	Medicine, Jg. 99 (2020-03-01), Heft 12, S. e19111
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2020
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000019111
Schlagwort:	China Drugs, Chinese Herbal administration & dosage Drugs, Chinese Herbal adverse effects Female Flavonoids administration & dosage Flavonoids adverse effects Humans Randomized Controlled Trials as Topic Drugs, Chinese Herbal therapeutic use Endometrium physiopathology Flavonoids therapeutic use Infertility, Female drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Systematic Review Language: English [Medicine (Baltimore)] 2020 Mar; Vol. 99 (12), pp. e19111. MeSH Terms: Drugs, Chinese Herbal / therapeutic use ; Endometrium / physiopathology ; Flavonoids / therapeutic use ; Infertility, Female / drug therapy ; China ; Drugs, Chinese Herbal / administration & dosage ; Drugs, Chinese Herbal / adverse effects ; Female ; Flavonoids / administration & dosage ; Flavonoids / adverse effects ; Humans ; Randomized Controlled Trials as Topic References: Reprod Biomed Online. 2014 Sep;29(3):291-8. (PMID: 25070912) ; Mol Med Rep. 2016 Aug;14(2):1316-22. (PMID: 27278906) ; Biomed Pharmacother. 2018 Dec;108:663-669. (PMID: 30245466) ; Reprod Biomed Online. 2019 Jul;39(1):49-62. (PMID: 31029557) ; Genet Mol Res. 2017 Jan 23;16(1):. (PMID: 28128406) ; Stem Cells Int. 2019 Jul 24;2019:7513404. (PMID: 31428160) ; Chem Biodivers. 2018 Apr;15(4):e1700578. (PMID: 29451707) ; Syst Rev. 2015 Jan 01;4:1. (PMID: 25554246) ; Fertil Res Pract. 2018 Aug 11;4:5. (PMID: 30116547) ; Front Endocrinol (Lausanne). 2018 Dec 20;9:776. (PMID: 30619099) ; Front Mol Neurosci. 2018 Jan 09;10:441. (PMID: 29375304) ; Zhongguo Zhong Yao Za Zhi. 2018 Dec;43(23):4709-4717. (PMID: 30717562) ; BMJ Evid Based Med. 2018 Jun;23(3):84-86. (PMID: 29650725) ; Stem Cells. 2015 Jun;33(6):1863-77. (PMID: 25787271) ; Front Pharmacol. 2017 Oct 12;8:734. (PMID: 29075193) ; Clin Biochem. 2018 Dec;62:2-10. (PMID: 29555319) ; Genet Mol Res. 2015 Sep 22;14(3):11250-8. (PMID: 26400356) ; Reprod Biol Endocrinol. 2010 Mar 24;8:30. (PMID: 20334664) ; Medicine (Baltimore). 2018 Jan;97(4):e9689. (PMID: 29369190) ; Gynecol Endocrinol. 2014 Jun;30(6):409-14. (PMID: 24693854) ; Zhongguo Gu Shang. 2018 Nov 25;31(11):1054-1060. (PMID: 30514049) ; Neural Regen Res. 2015 Jan;10(1):84-9. (PMID: 25788925) ; J Hum Reprod Sci. 2016 Jan-Mar;9(1):3-8. (PMID: 27110071) ; Mol Med Rep. 2018 May;17(5):6515-6525. (PMID: 29532868) ; J Int Med Res. 2018 Jun;46(6):2371-2385. (PMID: 29734850) ; Acta Biomater. 2018 Jul 1;74:156-167. (PMID: 29734010) ; Aging (Albany NY). 2019 Dec 2;11(23):10952-10991. (PMID: 31790362) ; Front Pharmacol. 2016 Jun 29;7:191. (PMID: 27445824) ; Eur J Pharmacol. 2019 Sep 5;858:172466. (PMID: 31220437) ; Am J Sports Med. 2019 Jul;47(8):1964-1974. (PMID: 31150275) ; Biomaterials. 2018 Jan;153:1-13. (PMID: 29096397) ; Zhonghua Fu Chan Ke Za Zhi. 2018 Nov 25;53(11):742-748. (PMID: 30453420) ; Reprod Biol Endocrinol. 2019 Nov 25;17(1):99. (PMID: 31767010) ; Int J Mol Med. 2018 Aug;42(2):831-838. (PMID: 29767263) ; Sci Rep. 2017 Sep 29;7(1):12445. (PMID: 28963488) ; Chin J Integr Med. 2015 Oct;21(10):765-71. (PMID: 25824551) ; J Clin Pathol. 2019 Sep;72(9):579-587. (PMID: 31296604) ; Calcif Tissue Int. 2016 Aug;99(2):187-98. (PMID: 27061090) ; Adv Biomed Res. 2018 Feb 21;7:36. (PMID: 29531934) Substance Nomenclature: 0 (Drugs, Chinese Herbal) ; 0 (Flavonoids) ; VNM47R2QSQ (icariin) Entry Date(s): Date Created: 20200321 Date Completed: 20200406 Latest Revision: 20221005 Update Code: 20231215 PubMed Central ID: PMC7220221

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The effect of icariin for infertile women with thin endometrium: A protocol for systematic review.