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Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of the alcohol metabolite acetaldehyde in the liver. In addition to conversion of the acetaldehyde molecule, ALDH is also involved in other cellular functions. Recently, many studies have investigated the involvement of ALDH expression in viral hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. Notably, ALDH2 expression has been linked with liver cancer risk, as well as pathogenesis and prognosis, and has emerged as a promising therapeutic target. Of note, approximately 8% of the world's population, and approximately 30-40% of the population in East Asia carry an inactive ALDH2 gene. This review summarizes new progress in understanding tissue-specific acetaldehyde metabolism by ALDH2 as well as the association of ALDH2 gene polymorphisms with liver disease and cancer. New research directions emerging in the field are also briefly discussed.

Competing Interests: Competing Interests: The authors have declared that no competing interest exists.

Titel:	Aldehyde Dehydrogenase, Liver Disease and Cancer.
Autor/in / Beteiligte Person:	Wang, W ; Wang, C ; Xu, H ; Gao, Y
Link:	Zum Volltext
Zeitschrift:	International journal of biological sciences, Jg. 16 (2020-01-22), Heft 6, S. 921
Veröffentlichung:	Lake Haven, N.S.W., Australia : Ivyspring International, c2004-, 2020
Medientyp:	academicJournal
ISSN:	1449-2288 (electronic)
DOI:	10.7150/ijbs.42300
Schlagwort:	Aldehyde Dehydrogenase genetics Animals Humans Liver metabolism Liver Neoplasms metabolism Polymorphism, Genetic genetics Aldehyde Dehydrogenase metabolism Liver enzymology Liver pathology Liver Neoplasms enzymology Liver Neoplasms pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review Language: English [Int J Biol Sci] 2020 Jan 22; Vol. 16 (6), pp. 921-934. <i>Date of Electronic Publication: </i>2020 Jan 22 (<i>Print Publication: </i>2020). MeSH Terms: Aldehyde Dehydrogenase / metabolism ; Liver / enzymology ; Liver / pathology ; Liver Neoplasms / enzymology ; Liver Neoplasms / *pathology ; Aldehyde Dehydrogenase / genetics ; Animals ; Humans ; Liver / metabolism ; Liver Neoplasms / metabolism ; Polymorphism, Genetic / genetics References: Sci Rep. 2017 Sep 11;7(1):11136. (PMID: 28894224) ; Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25974-25981. (PMID: 31792171) ; Pharmacol Rev. 2007 Jun;59(2):125-50. (PMID: 17379813) ; J Hepatol. 2015 Jun;62(6):1375-81. (PMID: 25543082) ; Hepatology. 2019 Aug;70(2):511-521. (PMID: 30125379) ; JAMA Oncol. 2017 Dec 1;3(12):1683-1691. (PMID: 28983565) ; Cancers (Basel). 2017 Sep 20;9(9):. 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(PMID: 26638120) Contributed Indexing: Keywords: aldehyde dehydrogenase; gene polymorphism; hepatocellular carcinoma; liver disease Substance Nomenclature: EC 1.2.1.3 (Aldehyde Dehydrogenase) Entry Date(s): Date Created: 20200307 Date Completed: 20210607 Latest Revision: 20210607 Update Code: 20240513 PubMed Central ID: PMC7053332

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Aldehyde Dehydrogenase, Liver Disease and Cancer.