Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients.
In: Clinica chimica acta; international journal of clinical chemistry, Jg. 503 (2020-04-01), S. 169
Online
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Zugriff:
Background: Reduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage.
Methods: A total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score >2 was evaluated as worse prognosis. A multivariable logistic model was conFig.d for assessing the relationship between serum omentin-1 concentrations and functional outcome.
Results: Serum omentin-1 concentrations, with the median value of 147.9 ng/ml (interquartile range, 114.7-199.8 ng/ml), were substantially declined with rising modified Rankin scale scores (P < 0.001). Serum omentin-1 concentrations <147.9 ng/ml was independently related to higher risk of 90-day worse prognosis (odds ratio, 3.789; 95% confidence interval, 1.819-8.608; P = 0.018). Under receiver operating characteristic curve, an optimal value of serum omentin-1 concentrations was selected as 179.7 ng/ml, which yielded 0.88 sensitivity value and 0.70 specificity value for discriminating patients at risk of 90-day worse prognosis (area under curve, 0.82; 95% confidence interval, 0.73-0.89).
Conclusions: Lower serum omentin-1 concentrations are closely associated with poor functional outcome after hemorrhagic stroke, substantializing serum omentin-1 as a potential prognostic biomarker for acute intracerebral hemorrhage.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
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Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients.
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Autor/in / Beteiligte Person: | Zhang, GH ; Ye, ZH ; Guan, HJ ; Guo, M ; Zhou, XX ; Xu, YY |
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Zeitschrift: | Clinica chimica acta; international journal of clinical chemistry, Jg. 503 (2020-04-01), S. 169 |
Veröffentlichung: | Amsterdam, Elsevier., 2020 |
Medientyp: | academicJournal |
ISSN: | 1873-3492 (electronic) |
DOI: | 10.1016/j.cca.2020.01.026 |
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