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Background: Following widespread use of the Haemophilus influenzae serotype b (Hib) vaccine, H. influenzae serotype a (Hia) has emerged as an important pathogen in children in some regions. We describe the clinical features and molecular epidemiology of invasive Hia disease in children in Utah over an 11-year period.

Methods: We identified cases of invasive Hia disease, defined as detection of Hia from a normally sterile site, in children aged <18 years from Utah between 2007 and 2017. Medical records were reviewed to determine demographic characteristics and clinical outcomes. Available Hia isolates were genotyped using multilocus sequence typing, and phylogenetic division was determined using sodC polymerase chain reaction. Presence of the putative virulence-associated IS1016-bexA duplication-deletion was evaluated.

Results: We identified 51 children with invasive Hia. The average annual incidence was 1.7 cases per 100 000 children aged <5 years; 4.8 cases per 100 000 children aged <1 year. The median age was 11.3 months. The most common clinical presentation was meningitis (53%), followed by pneumonia (14%) and septic arthritis (14%). Twenty-two children (43%) required admission to an intensive care unit; 1 died. Sequence type (ST) 62, phylogenetic division II isolates caused 75% (21/28) of disease. No isolates contained the virulence-associated IS1016-bexA duplication-deletion.

Conclusions: Hia is a significant cause of severe invasive bacterial infection in Utah. The majority of infections were caused by ST62 isolates, a phylogenetic division II Hia type that lacks the IS1016-bexA duplication-deletion. Hia ST62 has not been commonly reported elsewhere, suggesting a unique molecular epidemiology in our population.

(© The Author(s) 2019. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Titel:	Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.
Autor/in / Beteiligte Person:	Crandall, H ; Christiansen, J ; Varghese, AA ; Russon, A ; Korgenski, EK ; Bengtson, EK ; Dickey, M ; Killpack, J ; Knackstedt, ED ; Daly, JA ; Ampofo, K ; Pavia, AT ; Blaschke, AJ
Link:	Zum Volltext
Zeitschrift:	Journal of the Pediatric Infectious Diseases Society, Jg. 9 (2020-12-31), Heft 6, S. 650-655
Veröffentlichung:	Oxford : Oxford University Press, 2020
Medientyp:	academicJournal
ISSN:	2048-7207 (electronic)
DOI:	10.1093/jpids/piz088
Schlagwort:	Child Haemophilus influenzae genetics Humans Infant Molecular Epidemiology Phylogeny Serogroup Utah epidemiology Haemophilus Infections epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Pediatric Infect Dis Soc] 2020 Dec 31; Vol. 9 (6), pp. 650-655. MeSH Terms: Haemophilus Infections* / epidemiology ; Child ; Haemophilus influenzae / genetics ; Humans ; Infant ; Molecular Epidemiology ; Phylogeny ; Serogroup ; Utah / epidemiology References: Vaccine. 2017 Jul 24;35(33):4270-4275. (PMID: 28666758) ; BMC Infect Dis. 2018 Nov 22;18(1):592. (PMID: 30466407) ; Microb Pathog. 1986 Oct;1(5):465-73. (PMID: 3509884) ; Lancet Infect Dis. 2014 Jan;14(1):70-82. (PMID: 24268829) ; Proc Natl Acad Sci U S A. 1988 Oct;85(20):7758-62. (PMID: 2902639) ; J Med Microbiol. 1995 Aug;43(2):120-4. (PMID: 7629851) ; J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):261-264. (PMID: 29579288) ; Clin Infect Dis. 2010 Apr 1;50(7):e41-6. (PMID: 20178414) ; Pediatr Infect Dis J. 2007 Nov;26(11):1025-31. (PMID: 17984810) ; Can J Microbiol. 2013 May;59(5):362-4. (PMID: 23647351) ; Emerg Infect Dis. 2011 Sep;17(9):1645-50. (PMID: 21888789) ; J Bacteriol. 1988 Feb;170(2):859-64. (PMID: 2828329) ; J Clin Microbiol. 2012 Apr;50(4):1355-61. (PMID: 22238442) ; Clin Infect Dis. 2009 Oct 15;49(8):1240-3. (PMID: 19761408) ; Pediatr Infect Dis J. 2018 Apr;37(4):298-303. (PMID: 29189672) ; Clin Infect Dis. 2005 Mar 15;40(6):823-30. (PMID: 15736015) ; J Med Microbiol. 2011 Mar;60(Pt 3):384-390. (PMID: 21148281) ; Lancet. 2009 Sep 12;374(9693):903-11. (PMID: 19748399) ; J Infect Dis. 1993 Jul;168(1):172-6. (PMID: 8515106) ; J Infect Dis. 1981 Apr;143(4):517-24. (PMID: 6972419) ; Emerg Infect Dis. 2013 Jun;19(6):932-7. (PMID: 23735653) ; Clin Infect Dis. 2005 Dec 1;41(11):e97-103. (PMID: 16267724) ; Microb Pathog. 1989 Sep;7(3):225-35. (PMID: 2615636) ; Can J Microbiol. 2007 Oct;53(10):1191-4. (PMID: 18026212) ; Pediatr Infect Dis J. 1987 Aug;6(8):779-82. (PMID: 3313240) ; Clin Microbiol Rev. 2000 Apr;13(2):302-17. (PMID: 10756001) ; J Infect Dis. 2010 Nov 15;202(10):1577-84. (PMID: 20932170) ; J Exp Med. 1931 Mar 31;53(4):471-92. (PMID: 19869858) ; Infect Immun. 2003 Dec;71(12):7202-7. (PMID: 14638817) ; Clin Infect Dis. 2018 Aug 31;67(6):881-889. (PMID: 29509834) ; Int J Circumpolar Health. 2013 Aug 05;72:. (PMID: 25152869) ; Pediatrics. 2001 Jul;108(1):E18. (PMID: 11433097) ; Mem Inst Oswaldo Cruz. 2017 Mar;112(3):196-202. (PMID: 28225904) ; J Clin Microbiol. 2003 Apr;41(4):1623-36. (PMID: 12682154) ; Int J Infect Dis. 2017 Apr;57:104-107. (PMID: 28232014) ; J Infect Dis. 1977 Jan;135(1):34-41. (PMID: 299866) Grant Information: United Kingdom WT_ Wellcome Trust; K12 HD047349 United States HD NICHD NIH HHS Contributed Indexing: Keywords: Haemophilus influenza; children; Hia; ST62; meningitis Entry Date(s): Date Created: 20191221 Date Completed: 20210818 Latest Revision: 20230501 Update Code: 20231215 PubMed Central ID: PMC10147389

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Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.